Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0162 | 0.0162 |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Onchocerca volvulus | 0.0043 | 0.0162 | 0.051 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0099 | 0.148 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0172 | 0.317 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0099 | 0.148 | 0.5 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0043 | 0.0162 | 0.051 |
Onchocerca volvulus | 0.0043 | 0.0162 | 0.051 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 0.317 | 0.6693 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0464 | 1 | 1 |
Onchocerca volvulus | 0.0043 | 0.0162 | 0.051 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 0.317 | 0.6808 |
Giardia lamblia | High cysteine protein | 0.0043 | 0.0162 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 0.317 | 0.6693 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Echinococcus granulosus | peroxidasin | 0.0172 | 0.317 | 0.317 |
Echinococcus multilocularis | notch | 0.0043 | 0.0162 | 0.0162 |
Brugia malayi | PAS domain containing protein | 0.0048 | 0.0294 | 0.0631 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0043 | 0.0162 | 0.051 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0099 | 0.148 | 0.148 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0099 | 0.148 | 0.148 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 0.2956 | 0.6217 |
Onchocerca volvulus | Dual oxidase homolog | 0.0172 | 0.317 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0043 | 0.0162 | 0.0162 |
Echinococcus granulosus | fibropellin Ia | 0.0043 | 0.0162 | 0.0162 |
Brugia malayi | Peroxidasin | 0.0172 | 0.317 | 0.6808 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0235 | 0.4655 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0172 | 0.317 | 0.6808 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Onchocerca volvulus | Peroxidase homolog | 0.0172 | 0.317 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0172 | 0.317 | 0.6693 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0043 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Echinococcus multilocularis | neural cadherin | 0.0043 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0172 | 0.317 | 1 | |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Brugia malayi | hypothetical protein | 0.0162 | 0.2956 | 0.6349 |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Onchocerca volvulus | Putative cubilin | 0.0043 | 0.0162 | 0.051 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0043 | 0.0162 | 0.0162 |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Echinococcus multilocularis | peroxidasin | 0.0172 | 0.317 | 0.317 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0099 | 0.148 | 0.2934 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0464 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0099 | 0.148 | 0.4384 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0099 | 0.148 | 0.2934 |
Brugia malayi | Cadherin domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Onchocerca volvulus | 0.0043 | 0.0162 | 0.051 | |
Brugia malayi | hypoxia-induced factor 1 | 0.015 | 0.2662 | 0.5718 |
Schistosoma mansoni | peroxidasin | 0.0172 | 0.317 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Trichomonas vaginalis | AGC family protein kinase | 0.0099 | 0.148 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 0.317 | 0.6693 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Schistosoma mansoni | peroxidasin | 0.0172 | 0.317 | 1 |
Brugia malayi | Muscle positioning protein 4 | 0.0043 | 0.0162 | 0.0347 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0162 | 0.0162 |
Echinococcus multilocularis | slit 2 protein | 0.0043 | 0.0162 | 0.0162 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0043 | 0.0162 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0464 | 1 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0043 | 0.0162 | 0.0162 |
Trichomonas vaginalis | AGC family protein kinase | 0.0099 | 0.148 | 0.5 |
Brugia malayi | hypothetical protein | 0.0172 | 0.317 | 0.6808 |
Brugia malayi | Protein kinase domain containing protein | 0.0099 | 0.148 | 0.318 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Onchocerca volvulus | Slit protein homolog | 0.0043 | 0.0162 | 0.051 |
Mycobacterium ulcerans | putative regulatory protein | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | neural cadherin | 0.0043 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.015 | 0.2662 | 0.5564 |
Onchocerca volvulus | Peroxidasin homolog | 0.0172 | 0.317 | 1 |
Echinococcus granulosus | delta-like protein 1 | 0.0043 | 0.0162 | 0.0162 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 0.317 | 0.6808 |
Brugia malayi | Cadherin domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0162 | 0.0162 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Schistosoma mansoni | single-minded | 0.0048 | 0.0294 | 0.0439 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 0.317 | 0.6808 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0162 | 0.0162 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 0.317 | 0.6808 |
Echinococcus granulosus | protein jagged 2 | 0.0043 | 0.0162 | 0.0162 |
Echinococcus multilocularis | fibropellin Ia | 0.0043 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0043 | 0.0162 | 0.0347 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0048 | 0.0294 | 0.0439 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0043 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0043 | 0.0162 | 0.051 | |
Onchocerca volvulus | 0.0172 | 0.317 | 1 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0172 | 0.317 | 0.6693 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0043 | 0.0162 | 0.0162 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0043 | 0.0162 | 0.0162 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0099 | 0.148 | 0.318 |
Echinococcus granulosus | notch | 0.0043 | 0.0162 | 0.0162 |
Onchocerca volvulus | 0.0172 | 0.317 | 1 | |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0172 | 0.317 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0235 | 0.4655 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0172 | 0.317 | 0.6808 |
Onchocerca volvulus | Peroxidase homolog | 0.0172 | 0.317 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0043 | 0.0162 | 0.0162 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0043 | 0.0162 | 0.0162 |
Brugia malayi | EGF-like domain containing protein | 0.0043 | 0.0162 | 0.0347 |
Brugia malayi | Delta serrate ligand family protein | 0.0043 | 0.0162 | 0.0347 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0162 | 0.0162 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0043 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Echinococcus multilocularis | protein jagged 1 | 0.0043 | 0.0162 | 0.0162 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.317 | 0.6693 |
Brugia malayi | notch-like transmembrane receptor | 0.0043 | 0.0162 | 0.0347 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0043 | 0.0162 | 0.0347 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Antileishmanial activity Leishmania major V121 amastigotes | ChEMBL. | 20160053 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.