pI: 4.8085 |
Length (AA): 4483 |
MW (Da): 501113 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 23 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
483 | 1018 | 5szn (A) | 5 | 529 | 26.00 | 0 | 1 | 0.214263 | 1.43 |
502 | 571 | 1zvn (A) | 27 | 96 | 37.00 | 0.78 | 0.46 | 0.369815 | -0.34 |
696 | 806 | 2yst (A) | 5 | 119 | 39.00 | 0.000000000037 | 1 | 0.47196 | -0.03 |
712 | 1222 | 3q2w (A) | 7 | 540 | 20.00 | 0 | 1 | 0.188586 | 1.14 |
1028 | 1130 | 1wuz (A) | 5 | 103 | 21.00 | 0 | 0.99 | 0.252576 | -0.78 |
1246 | 1771 | 5dzv (A) | 3 | 526 | 18.00 | 0 | 1 | 0.0490321 | 1.76 |
1983 | 2194 | 5kj4 (A) | 899 | 1125 | 36.00 | 0 | 1 | 0.38449 | 0.27 |
2190 | 2269 | 2wbx (A) | 7 | 87 | 34.00 | 0.0031 | 0.97 | 0.394045 | -0.15 |
2393 | 2497 | 2ee0 (A) | 5 | 114 | 26.00 | 0.0031 | 0.99 | 0.353122 | -0.53 |
2399 | 2716 | 4xhz (A) | 795 | 1127 | 24.00 | 0 | 1 | 0.267635 | 0.31 |
2614 | 2708 | 1wuz (A) | 7 | 103 | 34.00 | 0.035 | 0.97 | 0.398391 | -0.16 |
2621 | 3137 | 5iry (A) | 16 | 460 | 28.00 | 0 | 1 | 0.0505246 | 1.89 |
2761 | 2821 | 4zmt (F) | 51 | 113 | 41.00 | 0.00016 | 0.65 | 0.371807 | 0.71 |
2924 | 3316 | 5szp (A) | 6 | 410 | 28.00 | 0 | 1 | 0.254865 | 1.17 |
2934 | 3408 | 3q2v (A) | 21 | 520 | 29.00 | 0 | 1 | 0.245156 | 1.55 |
2997 | 3408 | 1l3w (A) | 94 | 518 | 34.00 | 0 | 1 | 0.260103 | 1.66 |
3233 | 3318 | 1zvn (A) | 9 | 98 | 29.00 | 0 | 0.93 | 0.344784 | -0.41 |
3233 | 3318 | 3k6f (A) | 9 | 99 | 28.00 | 0 | 0.91 | 0.360784 | -0.56 |
3243 | 3322 | 1suh (A) | 21 | 104 | 43.00 | 0.011 | 1 | 0.444045 | -0.32 |
3932 | 4072 | 2ygq (A) | 160 | 274 | 38.00 | 0.00041 | 1 | 0.158652 | 1.17 |
3957 | 3993 | 1fsb (A) | 1 | 36 | 33.00 | 0 | 0.81 | 0.480853 | -1.17 |
3959 | 3995 | 1apo (A) | 49 | 84 | 36.00 | 0 | 1 | 0.531853 | -1.19 |
3960 | 3994 | 4wma (D) | 51 | 84 | 47.00 | 0 | 0.95 | 0.564407 | -0.48 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126716)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_43665 | Cadherin domain containing protein |
Brugia malayi | Bm1_43660 | Cadherin domain containing protein |
Brugia malayi | Bm1_24010 | Cadherin cytoplasmic region family protein |
Brugia malayi | Bm1_41340 | Cadherin domain containing protein |
Caenorhabditis elegans | CELE_F25F2.2 | Protein CDH-4, isoform B |
Caenorhabditis elegans | CELE_W02B9.1 | Protein HMR-1, isoform E |
Caenorhabditis elegans | CELE_R10F2.1 | Protein CDH-1 |
Drosophila melanogaster | Dmel_CG3352 | fat |
Drosophila melanogaster | Dmel_CG7100 | Cadherin-N |
Drosophila melanogaster | Dmel_CG17941 | dachsous |
Drosophila melanogaster | Dmel_CG7749 | kugelei |
Echinococcus granulosus | EgrG_000389000 | protocadherin 1 |
Echinococcus granulosus | EgrG_000824500 | fat cadherin tumor suppressor |
Echinococcus granulosus | EgrG_000660400 | neural cadherin |
Echinococcus granulosus | EgrG_000529700 | protocadherin gamma b17 |
Echinococcus multilocularis | EmuJ_000824500 | fat cadherin tumor suppressor |
Echinococcus multilocularis | EmuJ_000660400 | neural cadherin |
Echinococcus multilocularis | EmuJ_000390400 | protocadherin 1 |
Echinococcus multilocularis | EmuJ_000389000 | protocadherin 1 |
Homo sapiens | ENSG00000086570 | FAT atypical cadherin 2 |
Homo sapiens | ENSG00000196159 | FAT atypical cadherin 4 |
Homo sapiens | ENSG00000166341 | dachsous cadherin-related 1 |
Homo sapiens | ENSG00000197410 | dachsous cadherin-related 2 |
Homo sapiens | ENSG00000083857 | FAT atypical cadherin 1 |
Homo sapiens | ENSG00000107736 | cadherin-related 23 |
Homo sapiens | 100653137 | cadherin-23-like |
Homo sapiens | ENSG00000165323 | FAT atypical cadherin 3 |
Loa Loa (eye worm) | LOAG_04401 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02440 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15054 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06126 | hypothetical protein |
Loa Loa (eye worm) | LOAG_10844 | cadherin domain-containing protein |
Loa Loa (eye worm) | LOAG_03168 | cadherin domain-containing protein |
Loa Loa (eye worm) | LOAG_10612 | hypothetical protein |
Loa Loa (eye worm) | LOAG_02443 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00836 | hypothetical protein |
Loa Loa (eye worm) | LOAG_03530 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14790 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13920 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08910 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15616 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11272 | hypothetical protein |
Loa Loa (eye worm) | LOAG_12672 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13504 | cadherin domain-containing protein |
Mus musculus | ENSMUSG00000046743 | FAT tumor suppressor homolog 4 (Drosophila) |
Mus musculus | ENSMUSG00000074505 | FAT tumor suppressor homolog 3 (Drosophila) |
Mus musculus | ENSMUSG00000012819 | cadherin 23 (otocadherin) |
Mus musculus | ENSMUSG00000055333 | FAT tumor suppressor homolog 2 (Drosophila) |
Mus musculus | ENSMUSG00000070047 | FAT tumor suppressor homolog 1 (Drosophila) |
Mus musculus | ENSMUSG00000036862 | dachsous 1 (Drosophila) |
Schistosoma japonicum | Sjp_0016180 | Protocadherin Fat 1 precursor, putative |
Schistosoma japonicum | Sjp_0086720 | IPR002126,Cadherin,domain-containing |
Schistosoma japonicum | Sjp_0016170 | Protocadherin Fat 3 precursor, putative |
Schistosoma japonicum | Sjp_0016150 | Protocadherin Fat 3 precursor, putative |
Schistosoma japonicum | Sjp_0053190 | Protocadherin-11 X-linked precursor, putative |
Schistosoma japonicum | Sjp_0016200 | Putative fat-like cadherin-related tumor suppressor homolog precursor, putative |
Schistosoma japonicum | Sjp_0101780 | Protocadherin Fat 3 precursor, putative |
Schistosoma mansoni | Smp_135610 | hypothetical protein |
Schmidtea mediterranea | mk4.000344.10 | |
Schmidtea mediterranea | mk4.013629.01 | |
Schmidtea mediterranea | mk4.005370.01 | Protocadherin-like wing polarity protein stan |
Schmidtea mediterranea | mk4.031066.00 | |
Schmidtea mediterranea | mk4.004966.02 | |
Schmidtea mediterranea | mk4.001792.04 | Protocadherin-23 |
Schmidtea mediterranea | mk4.001792.06 | |
Schmidtea mediterranea | mk4.001747.03 | |
Schmidtea mediterranea | mk4.057394.00 | |
Schmidtea mediterranea | mk4.002524.03 | Cadherin-4 |
Schmidtea mediterranea | mk4.022628.00 | Putative cadherin |
Schmidtea mediterranea | mk4.001196.06 | Protocadherin-16 |
Schmidtea mediterranea | mk4.000909.00 | |
Schmidtea mediterranea | mk4.000378.05 | |
Schmidtea mediterranea | mk4.048920.00 | |
Schmidtea mediterranea | mk4.009780.03 | |
Schmidtea mediterranea | mk4.003784.01 | |
Schmidtea mediterranea | mk4.001196.05 | |
Schmidtea mediterranea | mk4.010655.00 | |
Schmidtea mediterranea | mk4.004966.03 | |
Schmidtea mediterranea | mk4.002273.01 | |
Schmidtea mediterranea | mk4.005370.00 | Cadherin-3 |
Schmidtea mediterranea | mk4.001196.07 | |
Schmidtea mediterranea | mk4.005725.00 | |
Schmidtea mediterranea | mk4.000336.07 | |
Schmidtea mediterranea | mk4.034112.00 | |
Schmidtea mediterranea | mk4.009038.00 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_W02B9.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_W02B9.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_W02B9.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_R10F2.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_R10F2.1 | Caenorhabditis elegans | slow growth | wormbase |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.