TDR Targets

Basic information

Technical information

TDR Targets ID: 1263884
Name: 2-methoxy-8-(4-methoxyphenyl)-6-(1-methylindo l-3-yl)pteridin-7-one
MW: 413.429 | Formula: C23H19N5O3
H donors: 0 H acceptors: 3 LogP: 3.06 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ncc2c(n1)n(c1ccc(cc1)OC)c(=O)c(n2)c1cn(c2c1cccc2)C
InChi: 1S/C23H19N5O3/c1-27-13-17(16-6-4-5-7-19(16)27)20-22(29)28(14-8-10-15(30-2)11-9-14)21-18(25-20)12-24-23(26-21)31-3/h4-13H,1-3H3
InChiKey: VHBVJKCDDRIJCQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-methoxy-8-(4-methoxyphenyl)-6-(1-methyl-3-indolyl)-7-pteridinone
NCGC00011419
PCOP-480818

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	hydroxysteroid (17-beta) dehydrogenase 10	Starlite/ChEMBL	No references
Homo sapiens	cytochrome P450, family 3, subfamily A, polypeptide 4	Starlite/ChEMBL	No references
Bacillus anthracis	Anthrax lethal factor	Starlite/ChEMBL	No references
Homo sapiens	ubiquitin specific peptidase 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	cytochrome P450 556	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	Get druggable targets OG5_129031	All targets in OG5_129031
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus multilocularis	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	IPR015063,Domain of unknown function DUF1873,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium hominis	ubiquitin specific protease 66	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania donovani	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium parvum	ubiquitin C-terminal hydrolase of the cysteine proteinase fold	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	CYP4Cod1	Get druggable targets OG5_126554	All targets in OG5_126554
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania mexicana	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	Get druggable targets OG5_129031	All targets in OG5_129031
Candida albicans	cytochrome P450 56	Get druggable targets OG5_126554	All targets in OG5_126554
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma brucei gambiense	ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Echinococcus granulosus	ubiquitin specific protease 41	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania donovani	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Cryptosporidium hominis	scully CG7113-PA	Get druggable targets OG5_129031	All targets in OG5_129031
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania braziliensis	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Candida albicans	ubiquitin-specific protease	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania braziliensis	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Candida albicans	closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma cruzi	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Brugia malayi	Cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	Get druggable targets OG5_127431	All targets in OG5_127431
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	Get druggable targets OG5_127431	All targets in OG5_127431
Candida albicans	similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11	Get druggable targets OG5_126554	All targets in OG5_126554
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	Ubiquitin carboxyl-terminal hydrolase 8, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	cytochrome P450 family protein	Get druggable targets OG5_126554	All targets in OG5_126554
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	Get druggable targets OG5_129031	All targets in OG5_129031
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania major	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Trypanosoma congolense	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	Get druggable targets OG5_129031	All targets in OG5_129031
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Schistosoma japonicum	ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative	Get druggable targets OG5_127431	All targets in OG5_127431
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	cytochrome p450-like protein	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania donovani	ubiquitin carboxyl-terminal hydrolase, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Cryptosporidium parvum	scully CG7113-PA, putative	Get druggable targets OG5_129031	All targets in OG5_129031
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Trypanosoma congolense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554
Leishmania mexicana	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Leishmania infantum	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	Get druggable targets OG5_127431	All targets in OG5_127431
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	Get druggable targets OG5_129031	All targets in OG5_129031
Trypanosoma brucei gambiense	cytochrome P450, putative	Get druggable targets OG5_126554	All targets in OG5_126554

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	ubiquitin specific protease, putative	ubiquitin specific peptidase 2	362 aa	378 aa	25.7 %
Brugia malayi	cytochrome P450	cytochrome P450, family 3, subfamily A, polypeptide 4	502 aa	492 aa	24.2 %
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	hydroxysteroid (17-beta) dehydrogenase 10	252 aa	251 aa	24.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	vav2	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/ALK protein kinase	0.0021	0.0776	0.0776
Schistosoma mansoni	tyrosine kinase	0.0097	1	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0076	0.741	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Schistosoma mansoni	tyrosine kinase	0.0097	1	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0021	0.0776	0.2132
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.3639	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Toxoplasma gondii	protein kinase	0.0021	0.0776	0.5
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0097	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Echinococcus granulosus	hypothetical protein	0.0076	0.741	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0076	0.741	0.741
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0097	1	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.3639	1
Schistosoma mansoni	GTPase activating protein	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK/ROR protein kinase	0.0021	0.0776	0.0776
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.3639	1
Echinococcus granulosus	N chimaerin	0.0076	0.741	0.7192
Echinococcus granulosus	tyrosine protein kinase shark	0.0097	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.741	0.741
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.741	0.741
Echinococcus granulosus	tyrosine protein kinase Blk	0.0097	1	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0021	0.0776	0.0776
Leishmania major	protein kinase, putative	0.0021	0.0776	0.1168
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK/FER protein kinase	0.0097	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0076	0.741	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Brugia malayi	Protein kinase domain containing protein	0.0097	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0097	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0776	0.0776
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0069	0.6645	0.5
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0097	1	1
Trypanosoma cruzi	protein kinase, putative	0.0021	0.0776	0.2132
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Onchocerca volvulus		0.0097	1	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0076	0.741	0.7192
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0076	0.741	0.7192
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0021	0.0776	0.2132
Schistosoma mansoni	tyrosine kinase	0.0097	1	1
Brugia malayi	Tensin	0.0076	0.741	0.741
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0776	0.0776
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0097	1	1
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/FER protein kinase	0.0097	1	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.3639	0.3639
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0021	0.0776	0.0776
Onchocerca volvulus		0.0097	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.741	0.741
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0097	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0097	1	1
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/FER protein kinase	0.0097	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0076	0.741	0.741
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Schistosoma mansoni	suppressor of cytokine signaling	0.0076	0.741	0.7192
Echinococcus granulosus	c src tyrosine kinase	0.0097	1	1
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0776	0.0776
Onchocerca volvulus		0.0076	0.741	0.7192
Plasmodium falciparum	tyrosine kinase-like protein	0.0021	0.0776	0.5
Entamoeba histolytica	protein kinase, putative	0.0076	0.741	0.7192
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0076	0.741	0.7192
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0076	0.741	0.741
Loa Loa (eye worm)	TK/ACK protein kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0076	0.741	0.741
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Echinococcus multilocularis	SH2 motif	0.0076	0.741	0.7192
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0076	0.741	0.7192
Trypanosoma cruzi	protein kinase, putative	0.0021	0.0776	0.2132
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Brugia malayi	Protein kinase domain containing protein	0.0097	1	1
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0069	0.6645	0.6363
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0076	0.741	0.7192
Schistosoma mansoni	tensin-related	0.0076	0.741	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Trypanosoma brucei	Pseudokinase, putative	0.0021	0.0776	0.2132
Plasmodium falciparum	protein kinase, putative	0.0021	0.0776	0.5
Brugia malayi	SH2 domain containing protein	0.0076	0.741	0.741
Schistosoma mansoni	tensin	0.0076	0.741	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Schistosoma mansoni	growth factor receptor-bound protein	0.0076	0.741	0.7192
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0097	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK/FER protein kinase	0.0097	1	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/FER protein kinase	0.0097	1	1
Schistosoma mansoni	nck2/grb4	0.0076	0.741	0.7192
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0076	0.741	0.741
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.3639	0.5476
Schistosoma mansoni	SH2A	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK/INSR protein kinase	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Echinococcus granulosus	SHC transforming protein 3	0.0076	0.741	0.7192
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0076	0.741	0.7192
Brugia malayi	SH2 domain containing protein	0.0097	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0097	1	1
Brugia malayi	Guanylyl cyclase protein 23	0.0021	0.0776	0.0776
Onchocerca volvulus		0.0076	0.741	0.7192
Echinococcus granulosus	SH2 motif	0.0076	0.741	0.7192
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0069	0.6645	0.6645
Schistosoma mansoni	adapter molecule crk	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK/FAK protein kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/FER protein kinase	0.0097	1	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0021	0.0776	0.0776
Echinococcus multilocularis	tyrosine protein kinase shark	0.0097	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0076	0.741	0.7192
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0076	0.741	0.7192
Schistosoma mansoni	tensin	0.0076	0.741	0.7192
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.3639	1
Schistosoma mansoni	hypothetical protein	0.0076	0.741	0.7192
Echinococcus multilocularis	c src tyrosine kinase	0.0097	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0097	1	1
Brugia malayi	SH2 domain containing protein	0.0076	0.741	0.741
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0076	0.741	0.741
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0021	0.0776	0.0776
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0076	0.741	0.7192
Loa Loa (eye worm)	SH2 domain-containing protein	0.0076	0.741	0.741
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0021	0.0776	0.5
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.3639	0.3104
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0097	1	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.3639	1
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Echinococcus granulosus	signal transduction protein lnk realted	0.0076	0.741	0.7192
Loa Loa (eye worm)	SH2 domain-containing protein	0.0076	0.741	0.741
Schistosoma mansoni	tensin-related	0.0076	0.741	0.7192
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.3639	0.3639
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.6645	1
Plasmodium vivax	protein kinase, putative	0.0021	0.0776	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0097	1	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0097	1	1
Schistosoma mansoni	hypothetical protein	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK/Met protein kinase	0.0021	0.0776	0.0776
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0076	0.741	0.7192
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0076	0.741	0.741
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0097	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.741	0.741
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0097	1	1
Brugia malayi	SH2 domain containing protein	0.0076	0.741	0.741
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0097	1	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0076	0.741	0.741
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0021	0.0776	0.2132
Brugia malayi	hypothetical protein	0.0076	0.741	0.741
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0076	0.741	0.7192
Schistosoma mansoni	tyrosine kinase	0.0097	1	1
Onchocerca volvulus		0.0097	1	1
Onchocerca volvulus		0.0076	0.741	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Leishmania major	protein kinase, putative	0.0021	0.0776	0.1168
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.3639	0.3104
Brugia malayi	RhoGAP domain containing protein	0.0076	0.741	0.741
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Brugia malayi	ephrin receptor 1 precursor	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0097	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0076	0.741	0.741
Brugia malayi	protein-tyrosine kinase	0.0097	1	1
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0069	0.6645	1
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0097	1	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0097	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0097	1	1
Brugia malayi	SRC-1	0.0097	1	1
Echinococcus granulosus	tyrosine kinase	0.0097	1	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0097	1	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.3639	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Echinococcus multilocularis	NCK adaptor protein	0.0076	0.741	0.7192
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0097	1	1
Echinococcus granulosus	SH2 domain containing protein 7	0.0076	0.741	0.7192
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0021	0.0776	0.0776
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0097	1	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0021	0.0776	0.0776
Schistosoma mansoni	shc transforming protein	0.0076	0.741	0.7192
Leishmania major	hypothetical protein, conserved	0.0021	0.0776	0.1168
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0776	0.0776
Schistosoma mansoni	tyrosine kinase	0.0097	1	1
Onchocerca volvulus		0.0097	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0776	0.0776
Brugia malayi	C-terminal src kinase protein 1	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0776	0.0776
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0021	0.0776	0.0776
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0097	1	1
Loa Loa (eye worm)	TK protein kinase	0.0097	1	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0021	0.0776	0.0776
Brugia malayi	Sex muscle abnormal protein 5	0.0076	0.741	0.741
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0097	1	1
Echinococcus multilocularis		0.0076	0.741	0.7192
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.3639	0.3104
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Brugia malayi	SH2 domain containing protein	0.0076	0.741	0.741
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Brugia malayi	SH2 domain containing protein	0.0076	0.741	0.741
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0076	0.741	0.7192
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.3639	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0097	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0021	0.0776	0.0776
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0076	0.741	0.7192
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0097	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0021	0.0776	0.5
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0065	0.6076	0.6076
Echinococcus multilocularis	SH2 motif	0.0076	0.741	0.7192
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0076	0.741	0.7192
Echinococcus granulosus	expressed conserved protein	0.0076	0.741	0.7192
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0021	0.0776	0.2132
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.6645	0.6363
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.3639	0.3104
Brugia malayi	hypothetical protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/FER protein kinase	0.0097	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Plasmodium falciparum	protein kinase, putative	0.0021	0.0776	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0021	0.0776	0.5
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0069	0.6645	0.6363
Schistosoma mansoni	suppressor of cytokine signaling	0.0076	0.741	0.7192
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0076	0.741	0.7192
Brugia malayi	Raf kinase	0.0021	0.0776	0.0776
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0097	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.741	0.7192
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.3639	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0021	0.0776	0.5
Trypanosoma brucei	protein kinase, putative	0.0021	0.0776	0.2132
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0021	0.0776	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Brugia malayi	SH2 domain containing protein	0.0076	0.741	0.741
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0097	1	1
Onchocerca volvulus		0.0076	0.741	0.7192
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK/FER protein kinase	0.0097	1	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0021	0.0776	0.0776
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0076	0.741	0.741
Echinococcus multilocularis	N chimaerin	0.0076	0.741	0.7192
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0097	1	1
Onchocerca volvulus		0.0097	1	1
Plasmodium falciparum	protein kinase, putative	0.0021	0.0776	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0076	0.741	0.7192
Brugia malayi	Protein kinase domain containing protein	0.0097	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0076	0.741	0.7192
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0021	0.0776	0.0776
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0021	0.0776	0.2132
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0776	0.0776
Brugia malayi	Furin-like cysteine rich region family protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0076	0.741	0.741
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.3639	0.3104
Toxoplasma gondii	STE kinase	0.0021	0.0776	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/CSK protein kinase	0.0021	0.0776	0.0776
Echinococcus multilocularis	SH2 motif	0.0076	0.741	0.7192
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0097	1	1
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0069	0.6645	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0076	0.741	0.7192
Brugia malayi	SH2 domain containing protein	0.0076	0.741	0.741
Echinococcus granulosus	growth factor receptor bound protein 2	0.0076	0.741	0.7192
Echinococcus multilocularis	tyrosine kinase	0.0097	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0776	0.0776
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0076	0.741	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.3639	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.3639	0.3104
Onchocerca volvulus		0.0097	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0097	1	1
Onchocerca volvulus		0.0076	0.741	0.7192
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0776	0.0776
Echinococcus granulosus	SH2 motif	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0776	0.0776
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0076	0.741	0.7192
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0021	0.0776	0.0776
Echinococcus multilocularis	SHC transforming protein 3	0.0076	0.741	0.7192
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.3639	0.3104
Echinococcus granulosus	tyrosine kinase	0.0097	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0076	0.741	0.7192
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Schistosoma mansoni	tyrosine kinase	0.0097	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0097	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0076	0.741	0.7192
Echinococcus multilocularis	tensin	0.0076	0.741	0.7192
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0776	0.0776
Brugia malayi	hypothetical protein	0.0097	1	1
Entamoeba histolytica	SH2 domain containing protein	0.0076	0.741	0.7192
Echinococcus granulosus	tensin	0.0076	0.741	0.7192
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Schistosoma mansoni	signal transduction protein lnk-related	0.0076	0.741	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0776	0.0776
Echinococcus multilocularis	tensin	0.0076	0.741	0.7192
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0021	0.0776	0.0776
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0776	0.0776
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0776	0.0776
Echinococcus granulosus	NCK adaptor protein	0.0076	0.741	0.7192
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0097	1	1
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0776	0.0776
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0097	1	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0021	0.0776	0.0776
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0021	0.0776	0.0776
Loa Loa (eye worm)	TK/ABL protein kinase	0.0097	1	1
Schistosoma mansoni	tensin	0.0076	0.741	0.7192
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Brugia malayi	hypothetical protein	0.0021	0.0776	0.0776
Onchocerca volvulus		0.0076	0.741	0.7192
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0097	1	1
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0776	0.0776
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0021	0.0776	0.0776
Loa Loa (eye worm)	SRC-1	0.0097	1	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0021	0.0776	0.0776
Brugia malayi	SH2 domain containing protein	0.0097	1	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.741	0.741
Plasmodium falciparum	tyrosine kinase-like protein	0.0021	0.0776	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0021	0.0776	0.5
Brugia malayi	integrin-linked kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	STAT protein	0.0076	0.741	0.741
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0021	0.0776	0.0776
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0021	0.0776	0.0776

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)		PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
AC50 (functional)	= 1.584893192 uM	PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active	ChEMBL.	No reference
Potency (ADMET)	= 1.5849 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (ADMET)	= 1.5849 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ]	ChEMBL.	No reference
Potency (functional)	= 3.9811 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1362416

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1263884