Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Tyrosine kinase homolog | 0.0159 | 0.012 | 0.0035 |
Brugia malayi | Choline O-acetyltransferase | 0.145 | 0.1204 | 0.1176 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.0062 | 0.026 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.6146 | 0.5149 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0054 | 0.0032 | 0.0062 |
Schistosoma mansoni | tyrosine kinase | 0.0089 | 0.0061 | 0.0246 |
Schistosoma mansoni | choline o-acyltransferase | 0.145 | 0.1204 | 1 |
Onchocerca volvulus | 0.145 | 0.1204 | 1 | |
Schistosoma mansoni | choline o-acyltransferase | 0.145 | 0.1204 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.009 | 0.0062 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 1.1922 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0168 | 0.0127 | 0.0127 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.2738 | 0.2286 | 0.4439 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0054 | 0.0032 | 0.0032 |
Brugia malayi | Choline O-acetyltransferase | 0.145 | 0.1204 | 0.1176 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.009 | 0.0062 | 0.0121 |
Onchocerca volvulus | 0.145 | 0.1204 | 1 | |
Echinococcus granulosus | insulin receptor | 0.0054 | 0.0032 | 0.0062 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.6146 | 0.5149 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0054 | 0.0032 | 0.0062 |
Schistosoma mansoni | tyrosine kinase | 0.009 | 0.0062 | 0.026 |
Onchocerca volvulus | 0.145 | 0.1204 | 1 | |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.017 | 0.0129 | 0.0129 |
Schistosoma mansoni | tyrosine kinase | 0.0089 | 0.0061 | 0.0246 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.145 | 0.1204 | 0.1204 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.2738 | 0.2286 | 1 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.2738 | 0.2286 | 0.2741 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.6146 | 0.5149 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.2738 | 0.2286 | 0.4439 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.6146 | 0.5149 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.6146 | 0.5149 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0054 | 0.0032 | 0.0062 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0168 | 0.0127 | 0.0096 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0168 | 0.0127 | 0.0247 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.2738 | 0.2286 | 0.2741 |
Loa Loa (eye worm) | hypothetical protein | 0.145 | 0.1204 | 0.1204 |
Echinococcus granulosus | choline O acetyltransferase | 0.145 | 0.1204 | 0.2339 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0168 | 0.0127 | 0.0247 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.145 | 0.1204 | 0.1204 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.2738 | 0.2286 | 0.2286 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.145 | 0.1204 | 0.1176 |
Onchocerca volvulus | 0.145 | 0.1204 | 1 | |
Schistosoma mansoni | tyrosine kinase | 0.0089 | 0.0061 | 0.0246 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.017 | 0.0129 | 0.0098 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.2738 | 0.2286 | 0.2261 |
Schistosoma mansoni | tyrosine kinase | 0.0168 | 0.0127 | 0.0812 |
Echinococcus multilocularis | 0.0052 | 0.003 | 0.0057 | |
Echinococcus multilocularis | choline O acetyltransferase | 0.145 | 0.1204 | 0.2339 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.009 | 0.0062 | 0.0121 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at 0.1 uM after 6 days by MTT colorimetric microassay | ChEMBL. | 22036229 | |
IC50 (functional) | = 5 uM | Anticancer activity against human LoVo cells after 5 days by MTT assay | ChEMBL. | 21067931 |
IC50 (functional) | = 6 uM | Anticancer activity against human A549 after 5 days by MTT assay | ChEMBL. | 21067931 |
IC50 (functional) | = 12 uM | Anticancer activity against human PC3 after 5 days by MTT assay | ChEMBL. | 21067931 |
IC50 (functional) | = 16 uM | Anticancer activity against human MCF7 after 5 days by MTT assay | ChEMBL. | 21067931 |
MBC (functional) | = 500 uM | Antimicrobial activity against Escherichia coli CIP 53126 after 18 to 24 hrs by broth microdilution method | ChEMBL. | 22036229 |
MIC (functional) | = 125 uM | Antimicrobial activity against Escherichia coli CIP 53126 after 18 to 24 hrs by broth microdilution method | ChEMBL. | 22036229 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21067931 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.