Detailed information for compound 1265224

Basic information

Technical information
  • TDR Targets ID: 1265224
  • Name: ethyl N-[11-(3-dimethylaminopropyl)-5,6-dihyd robenzo[b][1]benzazepin-9-yl]carbamate hydroc hloride
  • MW: 403.946 | Formula: C22H30ClN3O2
  • H donors: 1 H acceptors: 1 LogP: 5.04 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)Nc1ccc2c(c1)N(CCCN(C)C)c1ccccc1CC2.Cl
  • InChi: 1S/C22H29N3O2.ClH/c1-4-27-22(26)23-19-13-12-18-11-10-17-8-5-6-9-20(17)25(21(18)16-19)15-7-14-24(2)3;/h5-6,8-9,12-13,16H,4,7,10-11,14-15H2,1-3H3,(H,23,26);1H
  • InChiKey: PZDVINPJHGVCMT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[11-(3-dimethylaminopropyl)-5,6-dihydrobenzo[b][1]benzazepin-9-yl]carbamic acid ethyl ester hydrochloride
  • MLS001211303
  • SMR000517205
  • [5-(3-Dimethylamino-propyl)-10,11-dihydro-5H-dibenzo[b,f]azepin-3-yl]-carbamic acid ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0187 0.3719 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.3186 1
Onchocerca volvulus 0.0187 0.3719 1
Brugia malayi Steroid receptor seven-up type 2 0.0187 0.3719 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 1 0.5
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0187 0.3719 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.3719 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.3719 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.3719 1
Echinococcus multilocularis FTZ F1 alpha 0.0187 0.3719 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.3719 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0187 0.3719 1
Loa Loa (eye worm) steroid hormone receptor 0.0187 0.3719 1
Schistosoma mansoni nuclear hormone receptor 0.0187 0.3719 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0243 0.5
Loa Loa (eye worm) hypothetical protein 0.0099 0.0398 0.1071
Brugia malayi nuclear receptor RXR 0.0099 0.0398 0.1071
Schistosoma mansoni RAR-like nuclear receptor 0.0187 0.3719 1
Schistosoma mansoni thyroid hormone receptor 0.0187 0.3719 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0187 0.3719 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0243 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 1 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0187 0.3719 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0187 0.3719 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0187 0.3719 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0187 0.3719 1
Brugia malayi nuclear receptor NHR-88 0.0187 0.3719 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0243 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 1 0.5
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0243 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0099 0.0398 0.1071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0187 0.3719 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0187 0.3719 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0187 0.3719 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0187 0.3719 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0187 0.3719 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0187 0.3719 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0398 0.1071
Brugia malayi Nuclear hormone receptor-like 1 0.0099 0.0398 0.1071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0187 0.3719 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0398 0.1071
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.3186 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0187 0.3719 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0243 0.5
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0187 0.3719 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0187 0.3719 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0187 0.3719 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0099 0.0398 0.1071
Treponema pallidum fructose-bisphosphate aldolase 0.0353 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0187 0.3719 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0187 0.3719 1
Echinococcus granulosus ecdysone induced protein 78C 0.0187 0.3719 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.3719 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0187 0.3719 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0187 0.3719 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0243 0.0654
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0243 0.5
Loa Loa (eye worm) hypothetical protein 0.0187 0.3719 1
Schistosoma mansoni coup transcription factor 0.0187 0.3719 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0187 0.3719 1
Brugia malayi nuclear hormone receptor 0.0187 0.3719 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0187 0.3719 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0398 0.1071
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.3186 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 1 0.5
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0187 0.3719 1
Brugia malayi steroid hormone receptor 0.0187 0.3719 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 1 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0187 0.3719 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0187 0.3719 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0187 0.3719 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0099 0.0398 0.1071
Echinococcus multilocularis thyroid hormone receptor alpha 0.0187 0.3719 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0187 0.3719 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0187 0.3719 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0187 0.3719 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0187 0.3719 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0099 0.0398 0.1071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0187 0.3719 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0187 0.3719 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0099 0.0398 0.1071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 1 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0187 0.3719 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0243 0.0654
Brugia malayi ecdysteroid receptor 0.0187 0.3719 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0099 0.0398 0.1071
Brugia malayi Nuclear hormone receptor-like 1 0.0187 0.3719 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.3719 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0187 0.3719 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 1 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0099 0.0398 0.1071
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0243 0.0654
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0243 0.5
Echinococcus granulosus FTZ F1 alpha 0.0187 0.3719 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0187 0.3719 1
Brugia malayi hypothetical protein 0.0099 0.0398 0.1071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 1 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0187 0.3719 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0187 0.3719 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.0243 0.0654
Loa Loa (eye worm) hypothetical protein 0.0187 0.3719 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0187 0.3719 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0187 0.3719 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 1 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0187 0.3719 1
Brugia malayi hypothetical protein 0.0099 0.0398 0.1071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0187 0.3719 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0187 0.3719 1
Schistosoma mansoni thyroid hormone receptor 0.0187 0.3719 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0187 0.3719 1
Brugia malayi Probable ClpP-like protease 0.0094 0.0243 0.0654

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 23.0999 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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