Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase-related | 0.0699 | 0.3502 | 0.3399 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0204 | 0.0741 | 0.0673 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0192 | 0.0671 | 0.0811 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0156 | 0.0189 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1555 | 0.8275 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1658 | 0.8847 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Schistosoma mansoni | carbonic anhydrase | 0.0699 | 0.3502 | 0.3399 |
Schistosoma mansoni | hypothetical protein | 0.0699 | 0.3502 | 0.3399 |
Echinococcus granulosus | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0204 | 0.0741 | 0.0106 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0699 | 0.3502 | 0.4232 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0699 | 0.3502 | 0.4232 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1864 | 1 | 0.5 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0204 | 0.0741 | 0.0673 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1169 | 0.612 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0487 | 0.232 | 0.2803 |
Echinococcus granulosus | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0487 | 0.232 | 0.2198 |
Echinococcus granulosus | carbonic anhydrase II | 0.1555 | 0.8275 | 1 |
Brugia malayi | hypothetical protein | 0.01 | 0.0156 | 0.0189 |
Brugia malayi | Presenilin family protein | 0.0204 | 0.0741 | 0.0896 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0696 | 0.348 | 0.4689 |
Echinococcus multilocularis | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Plasmodium falciparum | carbonic anhydrase | 0.0699 | 0.3502 | 0.5 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0192 | 0.0671 | 0.0811 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1555 | 0.8275 | 0.8248 |
Echinococcus multilocularis | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Leishmania major | carbonic anhydrase-like protein | 0.1555 | 0.8275 | 0.8137 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0699 | 0.3502 | 0.3399 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0699 | 0.3502 | 0.4232 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1555 | 0.8275 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1555 | 0.8275 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1555 | 0.8275 | 1 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0204 | 0.0741 | 0.0106 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0192 | 0.0671 | 0.0634 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1864 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1864 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1555 | 0.8275 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0204 | 0.0741 | 0.0594 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0487 | 0.232 | 0.2803 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0699 | 0.3502 | 0.4232 |
Echinococcus granulosus | carbonic anhydrase | 0.0699 | 0.3502 | 0.4121 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0699 | 0.3502 | 0.4232 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0192 | 0.0671 | 0.0634 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0699 | 0.3502 | 0.4232 |
Brugia malayi | hypothetical protein | 0.01 | 0.0156 | 0.0189 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0487 | 0.232 | 0.2665 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1658 | 0.8847 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0699 | 0.3502 | 0.4232 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1555 | 0.8275 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0699 | 0.3502 | 0.4232 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1555 | 0.8275 | 1 |
Echinococcus multilocularis | presenilin | 0.0204 | 0.0741 | 0.072 |
Toxoplasma gondii | hypothetical protein | 0.0699 | 0.3502 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0962 | 0.4967 | 0.7679 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0487 | 0.232 | 0.2665 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0204 | 0.0741 | 0.0673 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0699 | 0.3502 | 0.3399 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0204 | 0.0741 | 0.0106 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1555 | 0.8275 | 0.8248 |
Loa Loa (eye worm) | hypothetical protein | 0.0699 | 0.3502 | 0.4232 |
Echinococcus granulosus | presenilin | 0.0204 | 0.0741 | 0.072 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1555 | 0.8275 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.