Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucosidase, alpha | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0.1091 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0044 | 0.1091 | 0.0969 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0044 | 0.1091 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.1091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1547 | 0.1547 |
Brugia malayi | hypothetical protein | 0.0064 | 0.2282 | 0.2043 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0044 | 0.1091 | 0.1091 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0.1091 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0044 | 0.1091 | 0.0815 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.1242 | 0.097 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.8406 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.1091 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0044 | 0.1091 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0044 | 0.1091 | 0.5 |
Schistosoma mansoni | alpha glucosidase | 0.0044 | 0.1091 | 0.1298 |
Schistosoma mansoni | jun-related protein | 0.0066 | 0.2413 | 0.287 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1075 | 0.0954 |
Echinococcus multilocularis | jun protein | 0.0082 | 0.3303 | 0.3212 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1413 | 0.1413 |
Echinococcus granulosus | jun protein | 0.0082 | 0.3303 | 0.3212 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.352 | 0.352 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.1091 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.1091 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.2997 | 0.3566 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.8406 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.3821 | 0.3629 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0082 | 0.3303 | 0.3212 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.1091 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0044 | 0.1091 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.1075 | 0.0954 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1247 | 0.1247 |
Onchocerca volvulus | 0.0114 | 0.5172 | 1 | |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2746 | 0.2647 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0044 | 0.1091 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0082 | 0.3303 | 0.3212 |
Trypanosoma brucei | glucosidase, putative | 0.0044 | 0.1091 | 0.5 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0044 | 0.1091 | 0.0969 |
Brugia malayi | bZIP transcription factor family protein | 0.0082 | 0.3303 | 0.3095 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0044 | 0.1091 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.2746 | 0.2647 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0044 | 0.1091 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0066 | 0.2413 | 0.287 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.0134 | 0.016 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0044 | 0.1091 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.