Detailed information for compound 1271380

Basic information

Technical information
  • TDR Targets ID: 1271380
  • Name: 3-(1,2,4-triazol-1-yl)pyridine
  • MW: 146.149 | Formula: C7H6N4
  • H donors: 0 H acceptors: 3 LogP: 0.59 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cn1)n1cncn1
  • InChi: 1S/C7H6N4/c1-2-7(4-8-3-1)11-6-9-5-10-11/h1-6H
  • InChiKey: JPUQBIHIIVYDAP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • MLS-0091919.0001

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily A, polypeptide 6 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily A, polypeptide 6 494 aa 485 aa 32.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0241 0.3725
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0241 1
Brugia malayi hypothetical protein 0.0047 0.0076 0.0076
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0241 0.3725
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0111 0.0519 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0047 0.0076 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0241 0.3725
Loa Loa (eye worm) hypothetical protein 0.0111 0.0519 0.0446
Loa Loa (eye worm) hypothetical protein 0.0071 0.0241 0.0166
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0241 0.0166
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Leishmania major hypothetical protein, conserved 0.0111 0.0519 1
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0759 0.0759
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0111 0.0519 0.0519
Schistosoma mansoni hypothetical protein 0.0125 0.0616 0.0616
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Brugia malayi PAS domain containing protein 0.0047 0.0076 0.0076
Onchocerca volvulus 0.0071 0.0241 1
Leishmania major hypothetical protein, conserved 0.0111 0.0519 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0111 0.0519 0.8415
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0241 0.0241
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.0759 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0111 0.0519 0.0519
Brugia malayi beta-lactamase family protein 0.0071 0.0241 0.0241
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0519 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Entamoeba histolytica hypothetical protein 0.0036 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0519 1
Onchocerca volvulus 0.0071 0.0241 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0111 0.0519 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0111 0.0519 0.0519
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0111 0.0519 0.8415
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0111 0.0519 0.0519
Schistosoma mansoni thyroid hormone receptor 0.0146 0.0759 0.0759
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0111 0.0519 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0241 0.3725
Trichomonas vaginalis esterase, putative 0.0071 0.0241 0.3725
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0111 0.0519 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0241 0.0166
Leishmania major cAMP-specific phosphodiesterase, putative 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0241 0.0166
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0111 0.0519 0.8415
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0234 0.0234
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0111 0.0519 0.5
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0076 0.0076
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0111 0.0519 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0111 0.0519 0.0519
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0111 0.0519 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Mycobacterium leprae Probable lipase LipE 0.0071 0.0241 1
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0608 0.9859
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Echinococcus multilocularis aryl hydrocarbon receptor 0.0047 0.0076 0.0999
Entamoeba histolytica hypothetical protein 0.0036 0 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0519 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.2867 1
Brugia malayi beta-lactamase family protein 0.0071 0.0241 0.0241
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0111 0.0519 0.0519
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0241 0.0166
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0047 0.0076 0.123
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 0.5
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0111 0.0519 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0616 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0111 0.0519 0.0519
Mycobacterium ulcerans beta-lactamase 0.0071 0.0241 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0241 0.0241
Plasmodium falciparum phosphodiesterase gamma, putative 0.0111 0.0519 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0111 0.0519 0.0519
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0111 0.0519 0.0519
Mycobacterium ulcerans hypothetical protein 0.0071 0.0241 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.0456 0.0456
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0111 0.0519 0.8415
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0241 0.3725
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0241 0.0241
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0111 0.0519 0.8415
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0111 0.0519 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0241 0.3173
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0519 1
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0111 0.0519 1
Echinococcus granulosus aryl hydrocarbon receptor 0.0047 0.0076 0.123
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0111 0.0519 0.0519
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0111 0.0519 0.6835
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0519 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0456 0.0383
Loa Loa (eye worm) hypothetical protein 0.0111 0.0519 0.0446
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0111 0.0519 0.6835
Entamoeba histolytica hypothetical protein 0.0036 0 0.5
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0111 0.0519 0.0519
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0111 0.0519 0.6835
Plasmodium vivax phosphodiesterase gamma, putative 0.0111 0.0519 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0241 0.3725
Plasmodium falciparum phosphodiesterase delta, putative 0.0111 0.0519 0.5
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0111 0.0519 0.0519
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0111 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.1375 0.9235 0.9229
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0111 0.0519 0.8415
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0111 0.0519 0.6835
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 0.5
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0111 0.0519 0.8415
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0111 0.0519 0.6835
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.1486 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0111 0.0519 0.6835
Giardia lamblia Hypothetical protein 0.0111 0.0519 0.5
Giardia lamblia hypothetical protein 0.0111 0.0519 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.0241 0.0166
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0608 0.8008
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0111 0.0519 0.6835
Schistosoma mansoni lipoxygenase 0.0124 0.0608 0.0608
Leishmania major hypothetical protein, conserved 0.0071 0.0241 0.3725
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0111 0.0519 0.5
Schistosoma mansoni single-minded 0.0047 0.0076 0.0076
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.1369 0.1304
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0111 0.0519 0.5
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0111 0.0519 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0111 0.0519 0.6835
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.0456 0.0383
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0241 0.5
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0241 0.3725
Loa Loa (eye worm) hypothetical protein 0.007 0.0234 0.0159
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0111 0.0519 0.0519
Brugia malayi beta-lactamase 0.0071 0.0241 0.0241
Schistosoma mansoni hypothetical protein 0.007 0.0234 0.0234
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Onchocerca volvulus 0.0071 0.0241 1
Schistosoma mansoni lipoxygenase 0.0087 0.0351 0.0351
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Loa Loa (eye worm) beta-lactamase 0.0071 0.0241 0.0166
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0616 0.8122
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0241 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0519 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0111 0.0519 0.0519
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.1369 0.1304
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0047 0.0076 0.0999
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0111 0.0519 1
Brugia malayi MH2 domain containing protein 0.0234 0.1369 0.1369
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.1486 1 1
Entamoeba histolytica hypothetical protein 0.0036 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1375 0.9235 0.9229
Loa Loa (eye worm) hypothetical protein 0.0071 0.0241 0.0166
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0111 0.0519 1
Loa Loa (eye worm) hypothetical protein 0.1486 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0111 0.0519 0.8415
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0111 0.0519 0.0446
Mycobacterium ulcerans lipase LipD 0.0071 0.0241 0.5
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0241 0.3906
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0519 1
Loa Loa (eye worm) PDE1B protein 0.0111 0.0519 0.0446
Loa Loa (eye worm) hypothetical protein 0.1375 0.9235 0.9229
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0111 0.0519 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0111 0.0519 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4200 nM BindingDB_Patents: Inhibition Assay. The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay (Greenlee et al., J Pharmacol Exp Ther, 1978). Our first studies were with highly purified human CYP2A6 that provided a convenient and relatively high-throughput measure of CYP2A6 inhibition. ChEMBL. No reference
IC50 (binding) = 4200 nM BindingDB_Patents: Inhibition Assay. The inhibition of human CYP2A6-mediated 7-hydroxy coumarin formation was evaluated in the presence of 95 selected test compounds in a standard assay (Greenlee et al., J Pharmacol Exp Ther, 1978). Our first studies were with highly purified human CYP2A6 that provided a convenient and relatively high-throughput measure of CYP2A6 inhibition. ChEMBL. No reference
IC50 (binding) > 100 um PUBCHEM_BIOASSAY: GAPDH Dose Response Colorimetric Assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 100 uM PUBCHEM_BIOASSAY: SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1548, AID1574, AID1577, AID1659, AID518] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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