Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0167 | 0.9146 | 0.9146 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0008 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.6334 | 0.6925 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0167 | 0.9146 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2539 | 0.2776 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.007 | 0.3121 | 0.3121 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0051 | 0.1952 | 0.2135 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2539 | 0.2776 |
Echinococcus multilocularis | geminin | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.6334 | 0.6925 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.007 | 0.3121 | 0.3121 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.6334 | 0.6925 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0104 | 0.5267 | 0.5267 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0008 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2539 | 0.2776 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0104 | 0.5267 | 0.5267 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.3121 | 0.3412 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0008 | 0.0009 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1364 | 0.1364 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0008 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0167 | 0.9146 | 0.9146 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0008 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0008 | 0.0009 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0008 | 0.0008 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0062 | 0.2663 | 0.2906 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0167 | 0.9146 | 1 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0104 | 0.5267 | 0.5267 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0167 | 0.9146 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0062 | 0.2663 | 0.2906 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0167 | 0.9146 | 0.9146 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2539 | 0.2776 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0062 | 0.2663 | 0.2906 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0051 | 0.1952 | 0.2135 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0062 | 0.2663 | 0.2906 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0104 | 0.5267 | 0.5267 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0167 | 0.9146 | 1 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0104 | 0.5267 | 0.5267 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0008 | 0.0008 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0104 | 0.5267 | 0.5267 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0008 | 0.0008 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0008 | 0.0008 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0104 | 0.5267 | 0.5267 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0008 | 0.5 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0167 | 0.9146 | 1 |
Brugia malayi | Melibiase family protein | 0.007 | 0.3121 | 0.3412 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0167 | 0.9146 | 1 |
Leishmania major | 0.0167 | 0.9146 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1364 | 0.1491 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0008 | 0.5 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0062 | 0.2663 | 0.2906 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.007 | 0.3121 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1364 | 0.1491 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0008 | 0.5 |
Toxoplasma gondii | melibiase subfamily protein | 0.0104 | 0.5267 | 0.5755 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0008 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.3089 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 39.8107 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.