Detailed information for compound 1275733

Basic information

Technical information
  • TDR Targets ID: 1275733
  • Name: 3-(4-chlorophenyl)-1-[2-hydroxy-3-(4-methoxyp henoxy)propyl]urea
  • MW: 350.797 | Formula: C17H19ClN2O4
  • H donors: 3 H acceptors: 2 LogP: 2.58 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)OCC(CNC(=O)Nc1ccc(cc1)Cl)O
  • InChi: 1S/C17H19ClN2O4/c1-23-15-6-8-16(9-7-15)24-11-14(21)10-19-17(22)20-13-4-2-12(18)3-5-13/h2-9,14,21H,10-11H2,1H3,(H2,19,20,22)
  • InChiKey: PMVWWJBPXNCZSW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • T0517-3252
  • MLS000391260
  • SMR000260297

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references
Trypanosoma brucei methionyl-tRNA synthetase, putative Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01874 methionyl-tRNA synthetase [EC6.1.1.10], putative Get druggable targets OG5_127468 All targets in OG5_127468
Onchocerca volvulus Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium berghei methionine--tRNA ligase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Candida albicans mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium knowlesi methionine--tRNA ligase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma congolense methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Toxoplasma gondii methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Babesia bovis methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Mycobacterium ulcerans methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium falciparum methionine--tRNA ligase Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania donovani methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma cruzi methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Cryptosporidium hominis methionine -- tRNA ligase Get druggable targets OG5_127468 All targets in OG5_127468
Theileria parva methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Loa Loa (eye worm) tyrosyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania major methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Loa Loa (eye worm) methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Giardia lamblia Methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Cryptosporidium parvum methionyl-tRNA synthetase of possible bacterial origin Get druggable targets OG5_127468 All targets in OG5_127468
Candida albicans mitochondrial tRNA methionyl-tRNA synthetase similar to S. cerevisiae MSM1 (YGR171C) mitochondrial methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Echinococcus multilocularis methionine tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Brugia malayi methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma brucei gambiense methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania infantum methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Trypanosoma brucei methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania mexicana methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium yoelii methionyl-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Plasmodium vivax methionine--tRNA ligase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Echinococcus granulosus methionine tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Mycobacterium leprae Probable methionyl-tRNA synthase MetS Get druggable targets OG5_127468 All targets in OG5_127468
Trichomonas vaginalis methionine-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) Get druggable targets OG5_127468 All targets in OG5_127468
Leishmania braziliensis methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Schistosoma mansoni methionine-tRNA synthetase Get druggable targets OG5_127468 All targets in OG5_127468
Theileria parva methionyl-tRNA synthetase, putative Get druggable targets OG5_127468 All targets in OG5_127468
Neospora caninum Methionine--tRNA ligase (EC 6.1.1.10), related Get druggable targets OG5_127468 All targets in OG5_127468
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0034 0.2121 0.2121
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0034 0.2121 0.2121
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.9223 0.9223
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0063 0.9223 0.9223
Schistosoma mansoni nAChR subunit 0.0063 0.9223 0.9223
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0063 0.9223 0.9223
Onchocerca volvulus 0.0034 0.2121 0.1438
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0034 0.2121 0.2121
Brugia malayi excitatory GABA receptor EXP-1A 0.0063 0.9223 0.9223
Onchocerca volvulus 0.0034 0.2121 0.1438
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0034 0.2121 0.2121
Loa Loa (eye worm) hypothetical protein 0.0034 0.2121 0.2121
Echinococcus multilocularis methionine tRNA synthetase 0.0066 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0928 0.0928
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0928 0.0928
Chlamydia trachomatis methionine--tRNA ligase 0.0025 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.2121 0.2121
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0063 0.9223 0.9223
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0063 0.9223 0.9223
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0063 0.9223 0.9223
Echinococcus multilocularis nAChR subunit 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Echinococcus multilocularis glycine receptor subunit beta 0.0063 0.9223 0.9223
Schistosoma mansoni nAChR subunit 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0063 0.9223 0.9223
Brugia malayi hypothetical protein 0.0029 0.0928 0.0928
Plasmodium falciparum methionine--tRNA ligase 0.0066 1 1
Loa Loa (eye worm) ACC-1 protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) ACC-1 protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Schistosoma mansoni nAChR subunit 0.0029 0.0928 0.0928
Brugia malayi hypothetical protein 0.0029 0.0928 0.0928
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Echinococcus multilocularis glycine receptor subunit beta 0.0063 0.9223 0.9223
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0063 0.9223 0.9223
Echinococcus granulosus nAChR subunit 0.0034 0.2121 0.2121
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0029 0.0928 0.0928
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0066 1 0.5
Echinococcus granulosus nAChR subunit 0.0063 0.9223 0.9223
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0063 0.9223 0.9223
Brugia malayi hypothetical protein 0.0029 0.0928 0.0928
Onchocerca volvulus 0.0063 0.9223 1
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Brugia malayi Cation transporter family protein 0.0063 0.9223 0.9223
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0034 0.2121 0.2121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Entamoeba histolytica hypothetical protein 0.0034 0.2121 1
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0066 1 1
Schistosoma mansoni methionine-tRNA synthetase 0.0066 1 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0063 0.9223 0.9223
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0066 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0034 0.2121 0.2121
Loa Loa (eye worm) acetylcholine receptor protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0034 0.2121 0.2121
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.2121 0.2121
Echinococcus granulosus glycine receptor subunit alpha 1 0.0063 0.9223 0.9223
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0066 1 0.5
Leishmania major methionyl-tRNA synthetase, putative 0.0066 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0063 0.9223 0.9223
Giardia lamblia Methionyl-tRNA synthetase 0.0066 1 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.9223 0.9223
Echinococcus granulosus glycine receptor subunit beta 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0063 0.9223 0.9223
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0066 1 1
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0063 0.9223 0.9223
Schistosoma mansoni nAChR subunit 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0063 0.9223 0.9223
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.9223 0.9223
Schistosoma mansoni acetylcholine receptor-related 0.0029 0.0928 0.0928
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.9223 0.9223
Treponema pallidum methionyl-tRNA synthetase 0.0025 0 0.5
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0029 0.0928 0.0928
Onchocerca volvulus 0.0063 0.9223 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0063 0.9223 0.9223
Echinococcus granulosus glycine receptor subunit beta 0.0063 0.9223 0.9223
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0063 0.9223 0.9223
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0066 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Schistosoma mansoni neurotransmitter gated ion channel 0.0034 0.2121 0.2121
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.9223 0.9223
Treponema pallidum leucyl-tRNA synthetase 0.0025 0 0.5
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0063 0.9223 0.9223
Schistosoma mansoni nAChR subunit 0.0063 0.9223 0.9223
Schistosoma mansoni nAChR subunit 0.0063 0.9223 0.9223
Plasmodium vivax methionine--tRNA ligase, putative 0.0066 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0041 0.3826 0.3826
Schistosoma mansoni nAChR subunit 0.0063 0.9223 0.9223
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0034 0.2121 0.2121
Toxoplasma gondii methionyl-tRNA synthetase 0.0066 1 1
Chlamydia trachomatis leucine--tRNA ligase 0.0025 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.9223 0.9223
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0063 0.9223 0.9223
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0034 0.2121 0.2121
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0034 0.2121 0.2121
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0066 1 0.5
Brugia malayi Cation transporter family protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Echinococcus multilocularis nAChR subunit 0.0034 0.2121 0.2121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0034 0.2121 0.2121
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0029 0.0928 0.0928
Schistosoma mansoni nAChR subunit 0.0063 0.9223 0.9223
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0063 0.9223 0.9223
Onchocerca volvulus 0.0063 0.9223 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Brugia malayi Cation transporter family protein 0.0063 0.9223 0.9223
Brugia malayi hypothetical protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Onchocerca volvulus 0.0063 0.9223 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0063 0.9223 0.9223
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0029 0.0928 0.0928
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.9223 0.9223
Echinococcus granulosus glycine receptor subunit alpha 1 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0063 0.9223 0.9223
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0063 0.9223 0.9223
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0063 0.9223 0.9223
Echinococcus granulosus methionine tRNA synthetase 0.0066 1 1
Onchocerca volvulus Putative nachr subunit 0.0063 0.9223 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0029 0.0928 0.0928
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0063 0.9223 0.9223
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0029 0.0928 0.0928
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0063 0.9223 0.9223
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0029 0.0928 0.0928
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.9223 0.9223
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0063 0.9223 0.9223
Onchocerca volvulus 0.0063 0.9223 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0063 0.9223 0.9223
Schistosoma mansoni neurotransmitter gated ion channel 0.0029 0.0928 0.0928
Onchocerca volvulus 0.0063 0.9223 1
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0029 0.0928 0.0928
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0063 0.9223 0.9223
Onchocerca volvulus 0.0041 0.3826 0.3494
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0063 0.9223 0.9223
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0066 1 1
Loa Loa (eye worm) GABA receptor subunit 0.0034 0.2121 0.2121
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0063 0.9223 0.9223
Echinococcus granulosus glycine receptor subunit alpha 1 0.0063 0.9223 0.9223
Schistosoma mansoni acetylcholine receptor subunit beta 0.0029 0.0928 0.0928
Schistosoma mansoni nAChR subunit 0.0063 0.9223 0.9223
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0029 0.0928 0.0928
Brugia malayi hypothetical protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) LGC-31 protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0063 0.9223 0.9223
Loa Loa (eye worm) hypothetical protein 0.0029 0.0928 0.0928
Loa Loa (eye worm) hypothetical protein 0.0034 0.2121 0.2121
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0063 0.9223 0.9223
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0063 0.9223 0.9223
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0029 0.0928 0.0928

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 4.392 uM PubChem BioAssay. Counterscreen Fluorescent Polarization-based biochemical high throughput orthogonal dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 4.659 uM PubChem BioAssay. Luminescence-based biochemical high throughput dose response assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3162 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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