Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1175 | 0.1175 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0537 | 0.0537 |
Loa Loa (eye worm) | carboxylesterase | 0.0299 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0537 | 0.0537 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.1175 | 0.0674 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1175 | 0.1175 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0051 | 0.1175 | 0.0674 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0537 | 0.0537 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1175 | 0.1175 |
Brugia malayi | hypothetical protein | 0.0051 | 0.1175 | 0.1175 |
Onchocerca volvulus | 0.0051 | 0.1175 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.0299 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0299 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0537 | 0.0537 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0051 | 0.1175 | 0.0674 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.1175 | 0.1175 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0051 | 0.1175 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0299 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0051 | 0.1175 | 0.0674 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0.1175 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0051 | 0.1175 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0051 | 0.1175 | 0.1175 |
Schistosoma mansoni | acetylcholinesterase | 0.0051 | 0.1175 | 0.0674 |
Loa Loa (eye worm) | carboxylesterase | 0.0051 | 0.1175 | 0.1175 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0051 | 0.1175 | 0.0674 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.1175 | 0.0674 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1175 | 0.1175 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1175 | 0.1175 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0051 | 0.1175 | 0.0674 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.1175 | 0.1175 |
Echinococcus granulosus | acetylcholinesterase | 0.0299 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0051 | 0.1175 | 0.0674 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0299 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.1175 | 0.1175 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0051 | 0.1175 | 0.0674 |
Onchocerca volvulus | 0.0051 | 0.1175 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0299 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0051 | 0.1175 | 0.0674 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0051 | 0.1175 | 0.0674 |
Onchocerca volvulus | 0.0051 | 0.1175 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0299 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0516 | 0.0516 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1175 | 0.1175 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0.1175 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0299 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0051 | 0.1175 | 0.1175 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0051 | 0.1175 | 0.0674 |
Echinococcus granulosus | neuroligin | 0.0051 | 0.1175 | 0.0674 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0537 | 0.0537 |
Onchocerca volvulus | 0.0051 | 0.1175 | 1 | |
Schistosoma mansoni | gliotactin | 0.0051 | 0.1175 | 0.0674 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0051 | 0.1175 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0051 | 0.1175 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1175 | 0.1175 |
Onchocerca volvulus | 0.0051 | 0.1175 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0631 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.