Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.2976 | 0.298 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0464 | 0.2991 | 1 |
Onchocerca volvulus | 0.0026 | 0.0122 | 1 | |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0899 | 0.5836 | 0.5836 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.002 | 0.0078 | 0.6421 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0026 | 0.0122 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0026 | 0.0122 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0122 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0122 | 0.0122 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0026 | 0.0122 | 1 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0078 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0026 | 0.0122 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0071 | 0.5844 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0464 | 0.2991 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0071 | 0.5844 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0122 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0122 | 0.0122 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0071 | 0.5844 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0464 | 0.2991 | 0.2995 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.002 | 0.0078 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1532 | 0.9985 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0122 | 0.0122 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Brugia malayi | AMP-binding enzyme family protein | 0.0026 | 0.0122 | 0.0122 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0026 | 0.0122 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0122 | 0.0122 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0019 | 0.0071 | 0.5844 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0026 | 0.0122 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0026 | 0.0122 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0122 | 0.0122 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0078 | 0.6421 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0026 | 0.0122 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0078 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0026 | 0.0122 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0078 | 0.0078 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.