TDR Targets

Basic information

Technical information

TDR Targets ID: 1297200
Name: ethyl 2-(2-ethoxy-2-oxoethyl)sulfanyl-4-methy l-1,3-thiazole-5-carboxylate
MW: 289.371 | Formula: C11H15NO4S2
H donors: 0 H acceptors: 3 LogP: 3.04 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)CSc1sc(c(n1)C)C(=O)OCC
InChi: 1S/C11H15NO4S2/c1-4-15-8(13)6-17-11-12-7(3)9(18-11)10(14)16-5-2/h4-6H2,1-3H3
InChiKey: NRDNYMGNGMMAFS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ethyl 2-(2-ethoxy-2-oxo-ethyl)sulfanyl-4-methyl-thiazole-5-carboxylate
2-[(2-ethoxy-2-oxoethyl)thio]-4-methyl-5-thiazolecarboxylic acid ethyl ester
2-[(2-ethoxy-2-keto-ethyl)thio]-4-methyl-thiazole-5-carboxylic acid ethyl ester
ethyl 2-(2-ethoxy-2-oxo-ethyl)sulfanyl-4-methyl-1,3-thiazole-5-carboxylate
ethyl 2-[(2-ethoxy-2-oxoethyl)thio]-4-methyl-1,3-thiazole-5-carboxylate
ZINC02710626
MLS000066726
SMR000082128

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0075	0.0485	0.2594
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0434	0.1013
Loa Loa (eye worm)	MH1 domain-containing protein	0.0034	0.01	0.01
Schistosoma mansoni	Smad4	0.0034	0.01	0.0234
Brugia malayi	isocitrate dehydrogenase	0.0079	0.0526	0.0526
Echinococcus multilocularis	GPCR, family 2	0.0224	0.187	1
Echinococcus granulosus	Smad4	0.0075	0.0485	0.2594
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0224	0.187	1
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0434	0.1013
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0056	0.0312	0.167
Plasmodium falciparum	ataxin-2 like protein, putative	0.0126	0.0955	1
Echinococcus granulosus	mothers against decapentaplegic 6	0.0034	0.01	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0709	0.6364	0.6364
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0079	0.0526	0.2742
Brugia malayi	hypothetical protein	0.0081	0.0542	0.0542
Trypanosoma brucei	PAB1-binding protein , putative	0.0126	0.0955	0.4982
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0079	0.0526	0.2742
Leishmania major	hypothetical protein, conserved	0.0126	0.0955	0.4982
Echinococcus multilocularis	mothers against decapentaplegic 2	0.0034	0.01	0.0536
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0069	0.0434	0.0434
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0224	0.187	0.187
Brugia malayi	MH1 domain containing protein	0.0075	0.0485	0.0485
Toxoplasma gondii	LsmAD domain-containing protein	0.0126	0.0955	1
Brugia malayi	RNA recognition motif domain containing protein	0.0069	0.0434	0.0434
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0744	0.6692	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0709	0.6364	0.6364
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0434	0.1013
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0075	0.0485	0.2594
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0434	0.1013
Loa Loa (eye worm)	Smad1	0.0075	0.0485	0.0485
Brugia malayi	Latrophilin receptor protein 2	0.0224	0.187	0.187
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0079	0.0526	0.2742
Trypanosoma cruzi	hypothetical protein, conserved	0.0229	0.1917	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.0075	0.0485	0.0485
Plasmodium vivax	ataxin-2 like protein, putative	0.0126	0.0955	1
Brugia malayi	Smad1	0.0075	0.0485	0.0485
Loa Loa (eye worm)	nuclear factor I	0.0041	0.0174	0.0174
Brugia malayi	TAR-binding protein	0.0069	0.0434	0.0434
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0224	0.187	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0302	0.0704
Schistosoma mansoni	smad	0.0034	0.01	0.0234
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0744	0.6692	0.6692
Echinococcus multilocularis	tar DNA binding protein	0.0069	0.0434	0.2321
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0302	0.1614
Echinococcus granulosus	mothers against decapentaplegic 5	0.0075	0.0485	0.2594
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0224	0.187	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0034	0.01	0.01
Onchocerca volvulus		0.0744	0.6692	1
Brugia malayi	MH1 domain containing protein	0.0075	0.0485	0.0485
Schistosoma mansoni	hypothetical protein	0.0056	0.0312	0.0729
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0079	0.0526	0.2811
Schistosoma mansoni	Smad4	0.0075	0.0485	0.1132
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0744	0.6692	0.6692
Echinococcus granulosus	smad	0.0075	0.0485	0.2594
Brugia malayi	MH2 domain containing protein	0.0075	0.0485	0.0485
Brugia malayi	MH1 domain containing protein	0.0041	0.0174	0.0174
Brugia malayi	RNA binding protein	0.0069	0.0434	0.0434
Schistosoma mansoni	smad1 5 8 and	0.0075	0.0485	0.1132
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0709	0.6364	0.6364
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0229	0.1917	0.2865
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0056	0.0312	0.167
Schistosoma mansoni	hypothetical protein	0.0224	0.187	0.4364
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0079	0.0526	0.5503
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0079	0.0526	0.2742
Loa Loa (eye worm)	TAR-binding protein	0.0069	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0197	0.1612	0.1612
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0744	0.6692	1
Echinococcus granulosus	GPCR family 2	0.0224	0.187	1
Schistosoma mansoni	smad1 5 8 and	0.0075	0.0485	0.1132
Leishmania major	hypothetical protein, conserved	0.0229	0.1917	1
Schistosoma mansoni	hypothetical protein	0.0224	0.187	0.4364
Echinococcus multilocularis	Smad4	0.0075	0.0485	0.2594
Echinococcus multilocularis	isocitrate dehydrogenase	0.0079	0.0526	0.2811
Loa Loa (eye worm)	RNA binding protein	0.0069	0.0434	0.0434
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0079	0.0526	0.0526
Echinococcus multilocularis	smad	0.0075	0.0485	0.2594
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0744	0.6692	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0126	0.0955	0.4982
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0224	0.187	0.187
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0709	0.6364	0.6364
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0744	0.6692	1
Schistosoma mansoni	tar DNA-binding protein	0.0069	0.0434	0.1013
Loa Loa (eye worm)	hypothetical protein	0.0034	0.01	0.01
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0302	0.1614
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0302	0.1614
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0079	0.0526	0.2811
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0744	0.6692	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0744	0.6692	1
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0744	0.6692	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0302	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0174	0.0174
Schistosoma mansoni	smad1 5 8 and	0.0075	0.0485	0.1132
Trypanosoma cruzi	hypothetical protein, conserved	0.0229	0.1917	1
Brugia malayi	hypothetical protein	0.0126	0.0955	0.0955
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0515	0.4564	1
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0744	0.6692	1
Schistosoma mansoni	hypothetical protein	0.0224	0.187	0.4364
Brugia malayi	MH2 domain containing protein	0.0034	0.01	0.01
Loa Loa (eye worm)	MH2 domain-containing protein	0.0075	0.0485	0.0485
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0955	0.0955
Brugia malayi	mothers against decapentaplegic homolog 3	0.0034	0.01	0.01
Schistosoma mansoni	smad	0.0075	0.0485	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0484	0.4284	0.4284
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0229	0.1917	1
Schistosoma mansoni	hypothetical protein	0.0484	0.4284	1
Brugia malayi	N-terminal motif family protein	0.0197	0.1612	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0224	0.187	0.187
Toxoplasma gondii	isocitrate dehydrogenase	0.0079	0.0526	0.5503
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0744	0.6692	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0079	0.0526	0.2811
Plasmodium falciparum	ataxin-2 like protein, putative	0.0126	0.0955	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0484	0.4284	0.4284
Toxoplasma gondii	isocitrate dehydrogenase	0.0079	0.0526	0.5503
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0229	0.1917	0.2865
Trypanosoma cruzi	PAB1-binding protein , putative	0.0126	0.0955	0.4982
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0079	0.0526	0.1152
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0079	0.0526	0.2811
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0079	0.0526	0.2811
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0079	0.0526	0.1227
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0079	0.0526	0.5503
Brugia malayi	MH1 domain containing protein	0.0041	0.0174	0.0174
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0744	0.6692	1
Schistosoma mansoni	Smad4	0.0034	0.01	0.0234
Echinococcus multilocularis	mothers against decapentaplegic 6	0.0034	0.01	0.0536
Schistosoma mansoni	hypothetical protein	0.0224	0.187	0.4364
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0302	0.0302
Echinococcus granulosus	tar DNA binding protein	0.0069	0.0434	0.2321
Echinococcus granulosus	mothers against decapentaplegic 2	0.0034	0.01	0.0536
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0302	0.0302
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0075	0.0485	0.2594
Brugia malayi	Isocitrate dehydrogenase	0.0079	0.0526	0.0526
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0079	0.0526	0.2742
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0075	0.0485	0.1132
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0197	0.1612	0.2294
Brugia malayi	MH2 domain containing protein	0.0075	0.0485	0.0485
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0302	0.1614
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0224	0.187	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0302	0.0704

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0126 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 0.3981 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 25.1189 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 56.2341 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1408517

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1297200