Detailed information for compound 1297200

Basic information

Technical information
  • TDR Targets ID: 1297200
  • Name: ethyl 2-(2-ethoxy-2-oxoethyl)sulfanyl-4-methy l-1,3-thiazole-5-carboxylate
  • MW: 289.371 | Formula: C11H15NO4S2
  • H donors: 0 H acceptors: 3 LogP: 3.04 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CSc1sc(c(n1)C)C(=O)OCC
  • InChi: 1S/C11H15NO4S2/c1-4-15-8(13)6-17-11-12-7(3)9(18-11)10(14)16-5-2/h4-6H2,1-3H3
  • InChiKey: NRDNYMGNGMMAFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-(2-ethoxy-2-oxo-ethyl)sulfanyl-4-methyl-thiazole-5-carboxylate
  • 2-[(2-ethoxy-2-oxoethyl)thio]-4-methyl-5-thiazolecarboxylic acid ethyl ester
  • 2-[(2-ethoxy-2-keto-ethyl)thio]-4-methyl-thiazole-5-carboxylic acid ethyl ester
  • ethyl 2-(2-ethoxy-2-oxo-ethyl)sulfanyl-4-methyl-1,3-thiazole-5-carboxylate
  • ethyl 2-[(2-ethoxy-2-oxoethyl)thio]-4-methyl-1,3-thiazole-5-carboxylate
  • ZINC02710626
  • MLS000066726
  • SMR000082128

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0079 0.0526 0.2811
Trypanosoma brucei PAB1-binding protein , putative 0.0126 0.0955 0.4982
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0302 0.1614
Brugia malayi TAR-binding protein 0.0069 0.0434 0.0434
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0515 0.4564 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0434 0.1013
Plasmodium falciparum ataxin-2 like protein, putative 0.0126 0.0955 1
Loa Loa (eye worm) hypothetical protein 0.0709 0.6364 0.6364
Echinococcus multilocularis mothers against decapentaplegic 2 0.0034 0.01 0.0536
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0302 0.1614
Loa Loa (eye worm) MH2 domain-containing protein 0.0034 0.01 0.01
Echinococcus granulosus tar DNA binding protein 0.0069 0.0434 0.2321
Loa Loa (eye worm) hypothetical protein 0.0034 0.01 0.01
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0302 0.0302
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0434 0.2321
Brugia malayi MH2 domain containing protein 0.0075 0.0485 0.0485
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0526 0.2811
Brugia malayi isocitrate dehydrogenase 0.0079 0.0526 0.0526
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0075 0.0485 0.2594
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0079 0.0526 0.2742
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0744 0.6692 0.6692
Echinococcus granulosus GPCR family 2 0.0224 0.187 1
Plasmodium vivax ataxin-2 like protein, putative 0.0126 0.0955 1
Loa Loa (eye worm) nuclear factor I 0.0041 0.0174 0.0174
Plasmodium falciparum ataxin-2 like protein, putative 0.0126 0.0955 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0744 0.6692 1
Brugia malayi MH1 domain containing protein 0.0075 0.0485 0.0485
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0229 0.1917 0.2865
Echinococcus multilocularis mothers against decapentaplegic 6 0.0034 0.01 0.0536
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0526 0.2742
Echinococcus multilocularis GPCR, family 2 0.0224 0.187 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0526 0.2742
Loa Loa (eye worm) RNA binding protein 0.0069 0.0434 0.0434
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0302 0.1614
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0302 0.0704
Echinococcus granulosus TGF beta signal transducer SmadC 0.0075 0.0485 0.2594
Brugia malayi MH1 domain containing protein 0.0075 0.0485 0.0485
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0744 0.6692 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0197 0.1612 0.2294
Brugia malayi MH2 domain containing protein 0.0075 0.0485 0.0485
Brugia malayi Smad1 0.0075 0.0485 0.0485
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0709 0.6364 0.6364
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0302 0.1614
Toxoplasma gondii LsmAD domain-containing protein 0.0126 0.0955 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0174
Schistosoma mansoni smad1 5 8 and 0.0075 0.0485 0.1132
Echinococcus granulosus Smad4 0.0075 0.0485 0.2594
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0056 0.0312 0.167
Schistosoma mansoni hypothetical protein 0.0224 0.187 0.4364
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0744 0.6692 0.6692
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0079 0.0526 0.5503
Loa Loa (eye worm) hypothetical protein 0.0197 0.1612 0.1612
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0079 0.0526 0.1152
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0434 0.1013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0526 0.2811
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0075 0.0485 0.1132
Schistosoma mansoni smad1 5 8 and 0.0075 0.0485 0.1132
Brugia malayi MH1 domain containing protein 0.0041 0.0174 0.0174
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0079 0.0526 0.1227
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0224 0.187 1
Schistosoma mansoni hypothetical protein 0.0224 0.187 0.4364
Echinococcus granulosus mothers against decapentaplegic 5 0.0075 0.0485 0.2594
Schistosoma mansoni smad 0.0075 0.0485 0.1132
Loa Loa (eye worm) Smad1 0.0075 0.0485 0.0485
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0744 0.6692 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0302 0.0704
Loa Loa (eye worm) hypothetical protein 0.0126 0.0955 0.0955
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0224 0.187 0.187
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0526 0.2811
Onchocerca volvulus 0.0744 0.6692 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0224 0.187 0.187
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0744 0.6692 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0079 0.0526 0.2811
Echinococcus granulosus mothers against decapentaplegic 2 0.0034 0.01 0.0536
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0434 0.0434
Brugia malayi latrophilin 2 splice variant baaae 0.0484 0.4284 0.4284
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0526 0.5503
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0229 0.1917 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0434 0.1013
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0434 0.0434
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0434 0.1013
Trypanosoma cruzi hypothetical protein, conserved 0.0229 0.1917 1
Brugia malayi N-terminal motif family protein 0.0197 0.1612 0.1612
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0744 0.6692 1
Echinococcus multilocularis smad 0.0075 0.0485 0.2594
Schistosoma mansoni hypothetical protein 0.0224 0.187 0.4364
Loa Loa (eye worm) hypothetical protein 0.0224 0.187 0.187
Brugia malayi MH2 domain containing protein 0.0034 0.01 0.01
Leishmania major hypothetical protein, conserved 0.0126 0.0955 0.4982
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0744 0.6692 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0075 0.0485 0.2594
Schistosoma mansoni Smad4 0.0034 0.01 0.0234
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0744 0.6692 1
Brugia malayi MH1 domain containing protein 0.0041 0.0174 0.0174
Schistosoma mansoni Smad4 0.0034 0.01 0.0234
Schistosoma mansoni smad 0.0034 0.01 0.0234
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.0955 0.4982
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0744 0.6692 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0744 0.6692 1
Schistosoma mansoni hypothetical protein 0.0224 0.187 0.4364
Schistosoma mansoni hypothetical protein 0.0056 0.0312 0.0729
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0434 0.1013
Leishmania major hypothetical protein, conserved 0.0229 0.1917 1
Brugia malayi mothers against decapentaplegic homolog 3 0.0034 0.01 0.01
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0079 0.0526 0.2811
Loa Loa (eye worm) MH1 domain-containing protein 0.0034 0.01 0.01
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0302 0.0704
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.0955 0.4982
Brugia malayi RNA binding protein 0.0069 0.0434 0.0434
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0224 0.187 1
Echinococcus granulosus smad 0.0075 0.0485 0.2594
Brugia malayi hypothetical protein 0.0126 0.0955 0.0955
Brugia malayi Calcitonin receptor-like protein seb-1 0.0709 0.6364 0.6364
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0744 0.6692 1
Brugia malayi hypothetical protein 0.0081 0.0542 0.0542
Echinococcus multilocularis Smad4 0.0075 0.0485 0.2594
Loa Loa (eye worm) MH1 domain-containing protein 0.0075 0.0485 0.0485
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0526 0.5503
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0302 0.0302
Brugia malayi Latrophilin receptor protein 2 0.0224 0.187 0.187
Loa Loa (eye worm) hypothetical protein 0.0484 0.4284 0.4284
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0434 0.0434
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0224 0.187 1
Echinococcus granulosus mothers against decapentaplegic 6 0.0034 0.01 0.0536
Schistosoma mansoni Smad4 0.0075 0.0485 0.1132
Loa Loa (eye worm) MH2 domain-containing protein 0.0075 0.0485 0.0485
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0056 0.0312 0.167
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0709 0.6364 0.6364
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0526 0.2742
Trypanosoma cruzi hypothetical protein, conserved 0.0229 0.1917 1
Brugia malayi Isocitrate dehydrogenase 0.0079 0.0526 0.0526
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0224 0.187 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0229 0.1917 0.2865
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0079 0.0526 0.2742
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0079 0.0526 0.5503
Schistosoma mansoni smad1 5 8 and 0.0075 0.0485 0.1132
Schistosoma mansoni hypothetical protein 0.0484 0.4284 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0079 0.0526 0.0526

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0126 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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