Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | sphingosine kinase, putative | 0.0079 | 0 | 0.5 |
Plasmodium vivax | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Plasmodium falciparum | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Schistosoma mansoni | sphingosine kinase A B | 0.2022 | 1 | 1 |
Trichomonas vaginalis | diacylglycerol kinase, zeta, iota, putative | 0.0079 | 0 | 0.5 |
Trichomonas vaginalis | diacylglycerol kinase, zeta, iota, putative | 0.0079 | 0 | 0.5 |
Trichomonas vaginalis | sphingosine kinase, putative | 0.0079 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0079 | 0 | 0.5 |
Trichomonas vaginalis | bmru protein, putative | 0.0079 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | Diacylglycerol kinase catalytic domain containing protein, putative | 0.0079 | 0 | 0.5 |
Toxoplasma gondii | diacylglycerol kinase catalytic domain-containing protein | 0.0079 | 0 | 0.5 |
Onchocerca volvulus | Ceramide kinase 1 homolog | 0.0079 | 0 | 0.5 |
Leishmania major | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.2022 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.2022 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | diacylglycerol kinase-like protein, putative | 0.0079 | 0 | 0.5 |
Plasmodium vivax | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Plasmodium falciparum | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0337 | 0.0337 |
Trypanosoma cruzi | diacylglycerol kinase-like protein, putative | 0.0079 | 0 | 0.5 |
Trypanosoma brucei | Sphingosine kinase | 0.0079 | 0 | 0.5 |
Trichomonas vaginalis | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0337 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0079 | 0 | 0.5 |
Trypanosoma brucei | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | Sphingosine kinase | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | Sphingosine kinase | 0.0079 | 0 | 0.5 |
Trichomonas vaginalis | bmru protein, putative | 0.0079 | 0 | 0.5 |
Schistosoma mansoni | sphingoid long chain base kinase | 0.2022 | 1 | 1 |
Toxoplasma gondii | diacylglycerol kinase accessory domain (presumed) domain-containing protein | 0.0079 | 0 | 0.5 |
Trichomonas vaginalis | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Echinococcus multilocularis | sphingosine kinase 1 | 0.2022 | 1 | 1 |
Onchocerca volvulus | 0.0079 | 0 | 0.5 | |
Trichomonas vaginalis | diacylglycerol kinase, epsilon, putative | 0.0079 | 0 | 0.5 |
Leishmania major | sphingosine kinase A, B, putative | 0.0079 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.2022 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0337 | 0.0337 |
Trypanosoma cruzi | diacylglycerol kinase, putative | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2022 | 1 | 1 |
Leishmania major | diacylglycerol kinase-like protein | 0.0079 | 0 | 0.5 |
Trypanosoma brucei | Diacylglycerol kinase catalytic domain containing protein, putative | 0.0079 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.