TDR Targets

Basic information

Technical information

TDR Targets ID: 1314695
Name: 1-(3-dimethylaminopropyl)-3-(4-phenylphenyl)t hiourea
MW: 313.46 | Formula: C18H23N3S
H donors: 1 H acceptors: 0 LogP: 3.82 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCCN=C(Nc1ccc(cc1)c1ccccc1)S)C
InChi: 1S/C18H23N3S/c1-21(2)14-6-13-19-18(22)20-17-11-9-16(10-12-17)15-7-4-3-5-8-15/h3-5,7-12H,6,13-14H2,1-2H3,(H2,19,20,22)
InChiKey: VNPACMJIGFGMCR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS001010745
SMR000385097
T5321603

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	neuropeptide FF receptor 2	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.017	0.0378
Brugia malayi	hypothetical protein	0.0012	0.0334	0.0721
Schistosoma mansoni	amine GPCR	0.0012	0.0334	0.0334
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.001	0.0205	0.0456
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.1789	0.1789
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.1642	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0334	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0334	0.0334
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0334	0.0334
Onchocerca volvulus		0.0012	0.0334	0.0487
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.017	0.017
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0334	0.0334
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0751	0.162
Schistosoma mansoni	hypothetical protein	0.0012	0.0334	0.0334
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.001	0.017	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Schistosoma mansoni	hypothetical protein	0.0019	0.0751	0.0751
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0334	0.0334
Brugia malayi	hypothetical protein	0.0012	0.0334	0.0721
Schistosoma mansoni	hypothetical protein	0.0019	0.0751	0.0751
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Schistosoma mansoni	nuclear hormone receptor	0.001	0.017	0.017
Loa Loa (eye worm)	TYRA-2 protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus multilocularis	G protein coupled receptor 139	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.001	0.017	0.0378
Brugia malayi	neuropeptide F receptor	0.0012	0.0334	0.0721
Brugia malayi	Melatonin receptor type 1A	0.0012	0.0334	0.0721
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0012	0.0334	0.0334
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.017	0.0366
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.4148	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.017	0.017
Echinococcus granulosus	FTZ F1 alpha	0.001	0.017	0.017
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Schistosoma mansoni	myosin xvIII	0.0012	0.0334	0.0334
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.017	0.017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.001	0.017	0.0378
Schistosoma mansoni	hypothetical protein	0.0012	0.0334	0.0334
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.4148	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0334	0.0334
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	neuropeptide receptor A26	0.0012	0.0334	0.0334
Echinococcus granulosus	GPCR family 2	0.0019	0.0751	0.0751
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0012	0.0334	0.0743
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	dro:myosuppressin receptor	0.0012	0.0334	0.0334
Brugia malayi	Dopamine receptor protein 2	0.0012	0.0334	0.0721
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.017	0.017
Onchocerca volvulus		0.0012	0.0334	0.0487
Schistosoma mansoni	amine GPCR	0.0012	0.0334	0.0334
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.4148	0.4148
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.017	0.0366
Schistosoma mansoni	hypothetical protein	0.0041	0.2134	0.2134
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.017	0.017
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	somatostatin receptor	0.0012	0.0334	0.0334
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.3327	0.7175
Schistosoma mansoni	jun-related protein	0.0066	0.3685	0.3685
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0334	0.0334
Brugia malayi	Serotonin receptor	0.0012	0.0334	0.0721
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Brugia malayi	ecdysteroid receptor	0.001	0.017	0.0366
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.4148	0.4148
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0012	0.0334	0.0743
Echinococcus granulosus	hypothetical protein	0.0012	0.0334	0.0334
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.017	0.0366
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0081	0.4637	0.4637
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0334	0.0334
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.017	0.0366
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.4148	0.4148
Brugia malayi	RE15519p	0.0012	0.0334	0.0721
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.1642	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0751	0.167
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.017	0.0366
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.017	0.017
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.017	0.017
Brugia malayi	putative neuropeptide receptor	0.0012	0.0334	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Schistosoma mansoni	hypothetical protein	0.0019	0.0751	0.0751
Brugia malayi	hypothetical protein	0.0012	0.0334	0.0721
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0012	0.0334	0.0334
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Echinococcus granulosus	G protein coupled receptor 139	0.0012	0.0334	0.0334
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.017	0.017
Echinococcus granulosus	serotonin receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	sex peptide receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.017	0.017
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Echinococcus granulosus	fmrfamide receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0012	0.0334	0.0487
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0081	0.4637	0.4637
Schistosoma mansoni	opsin-like receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Brugia malayi	Dopamine receptor protein 1	0.0012	0.0334	0.0721
Echinococcus multilocularis	serotonin receptor	0.0012	0.0334	0.0334
Brugia malayi	hypothetical protein	0.0012	0.0334	0.0721
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0012	0.0334	0.0334
Onchocerca volvulus		0.0012	0.0334	0.0487
Onchocerca volvulus		0.0012	0.0334	0.0487
Echinococcus multilocularis	neuropeptide receptor A26	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.001	0.017	0.0378
Onchocerca volvulus		0.0064	0.3546	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.001	0.017	0.0378
Schistosoma mansoni	hypothetical protein	0.0019	0.0751	0.0751
Loa Loa (eye worm)	hypothetical protein	0.001	0.017	0.0378
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Echinococcus granulosus	biogenic amine 5HT receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0334	0.0334
Brugia malayi	G-protein coupled receptor	0.0012	0.0334	0.0721
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.017	0.0378
Echinococcus granulosus	7TM GPCR rhodopsin	0.0012	0.0334	0.0334
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0334	0.0743
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.001	0.0205	0.0442
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.017	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.017	0.017
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.2134	0.4604
Echinococcus multilocularis	voltage gated potassium channel	0.001	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0751	0.167
Echinococcus multilocularis	g-protein coupled receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.017	0.017
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	neuropeptide s receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	histamine h1 receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	jun protein	0.0081	0.4637	0.4637
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.4148	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Onchocerca volvulus		0.0012	0.0334	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0012	0.0334	0.0334
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0012	0.0334	0.0721
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0751	0.0751
Echinococcus multilocularis	serotonin receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0751	0.0751
Schistosoma mansoni	neuropeptide F-like receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0334	0.0334
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0012	0.0334	0.0334
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.017	0.017
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0334	0.0743
Brugia malayi	nuclear receptor NHR-88	0.001	0.017	0.0366
Echinococcus multilocularis	dro:myosuppressin receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.4148	0.4148
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0012	0.0334	0.0721
Brugia malayi	follicle stimulating hormone receptor	0.0012	0.0334	0.0721
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.017	0.0378
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.017	0.017
Schistosoma mansoni	hypothetical protein	0.0012	0.0334	0.0334
Brugia malayi	ORL1-like opioid receptor	0.0012	0.0334	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.017	0.017
Onchocerca volvulus		0.0012	0.0334	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus granulosus	orexin receptor type 2	0.0012	0.0334	0.0334
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0012	0.0334	0.0743
Schistosoma mansoni	coup transcription factor	0.001	0.017	0.017
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0205	0.0205
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0751	0.0751
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.017	0.017
Schistosoma mansoni	thyroid hormone receptor	0.001	0.017	0.017
Onchocerca volvulus		0.0012	0.0334	0.0487
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.1789	0.3859
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	opsin-like receptor	0.0012	0.0334	0.0334
Onchocerca volvulus		0.0012	0.0334	0.0487
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Brugia malayi	putative neuropeptide receptor NPR1	0.0012	0.0334	0.0721
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.006	0.3327	0.7397
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.017	0.0378
Brugia malayi	sulfakinin receptor protein	0.0012	0.0334	0.0721
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.017	0.017
Onchocerca volvulus		0.0012	0.0334	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.017	0.0366
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.017	0.017
Schistosoma mansoni	adenoreceptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Onchocerca volvulus		0.0012	0.0334	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.017	0.0366
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.3327	0.7175
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.017	0.0366
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.017	0.0378
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.3327	0.7397
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.017	0.0366
Echinococcus granulosus	somatostatin receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.017	0.017
Loa Loa (eye worm)	melatonin receptor type 1A	0.0012	0.0334	0.0743
Brugia malayi	AKH receptor	0.0012	0.0334	0.0721
Brugia malayi	hypothetical protein	0.0012	0.0334	0.0721
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Echinococcus granulosus	neuropeptide Y receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.001	0.017	0.0378
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0334	0.0334
Schistosoma mansoni	biogenic amine receptor	0.0012	0.0334	0.0334
Onchocerca volvulus		0.0012	0.0334	0.0487
Echinococcus granulosus	allatostatin A receptor	0.0012	0.0334	0.0334
Brugia malayi	hypothetical protein	0.0012	0.0334	0.0721
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.017	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.4148	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0334	0.0334
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0012	0.0334	0.0487
Onchocerca volvulus		0.0012	0.0334	0.0487
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.4148	0.5
Schistosoma mansoni	thyroid hormone receptor	0.001	0.017	0.017
Echinococcus multilocularis	allatostatin A receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.017	0.017
Brugia malayi	G protein-coupled receptor	0.0012	0.0334	0.0721
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.001	0.0205	0.0205
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0012	0.0334	0.0334
Brugia malayi	G-protein coupled receptor	0.0012	0.0334	0.0721
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	g-protein coupled receptor	0.0012	0.0334	0.0334
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.017	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0334	0.0334
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.017	0.017
Loa Loa (eye worm)	hypothetical protein	0.001	0.017	0.0378
Echinococcus granulosus	neuropeptide receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	neuropeptide receptor	0.0012	0.0334	0.0334
Onchocerca volvulus		0.0012	0.0334	0.0487
Brugia malayi	nuclear hormone receptor	0.001	0.017	0.0366
Echinococcus granulosus	7tm_1 domain containing protein	0.0012	0.0334	0.0334
Echinococcus multilocularis	neuropeptides capa receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.1994	0.1994
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0751	0.0751
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0334	0.0334
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0012	0.0334	0.0334
Echinococcus multilocularis	orexin receptor type 2	0.0012	0.0334	0.0334
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.017	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0012	0.0334	0.0721
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.017	0.017
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.1994	0.1994
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Schistosoma mansoni	opsin-like receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1495	0.3323
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0334	0.0334
Schistosoma mansoni	voltage-gated potassium channel	0.001	0.0205	0.0205
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Echinococcus multilocularis	fmrfamide receptor	0.0012	0.0334	0.0334
Brugia malayi	hypothetical protein	0.0012	0.0334	0.0721
Echinococcus multilocularis	neuropeptide Y receptor	0.0012	0.0334	0.0334
Onchocerca volvulus		0.0012	0.0334	0.0487
Onchocerca volvulus		0.0012	0.0334	0.0487
Echinococcus multilocularis	neuropeptide s receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	amine GPCR	0.0012	0.0334	0.0334
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	neuropeptide f receptor 76f	0.0012	0.0334	0.0334
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.1789	0.3978
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0334	0.0334
Loa Loa (eye worm)	neuropeptide F receptor	0.0012	0.0334	0.0743
Schistosoma mansoni	growth hormone secretagogue receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0012	0.0334	0.0334
Brugia malayi	hypothetical protein	0.0012	0.0334	0.0721
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus granulosus	neuropeptides capa receptor	0.0012	0.0334	0.0334
Brugia malayi	hypothetical protein	0.0064	0.3546	0.7648
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.001	0.0205	0.0205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Schistosoma mansoni	amine GPCR	0.0012	0.0334	0.0334
Onchocerca volvulus		0.0012	0.0334	0.0487
Echinococcus granulosus	sex peptide receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	amine GPCR	0.0012	0.0334	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0334	0.0334
Brugia malayi	GnHR receptor homolog	0.0012	0.0334	0.0721
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.017	0.017
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0012	0.0334	0.0743
Echinococcus multilocularis	neuropeptide receptor	0.0012	0.0334	0.0334
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0012	0.0334	0.0334
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0012	0.0334	0.0334
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.017	0.017
Echinococcus multilocularis	jun protein	0.0081	0.4637	0.4637
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.017	0.0366
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0012	0.0334	0.0334
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0751	0.162
Brugia malayi	hypothetical protein	0.0012	0.0334	0.0721
Loa Loa (eye worm)	G-protein coupled receptor	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.4148	0.5
Brugia malayi	bZIP transcription factor family protein	0.0081	0.4637	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0012	0.0334	0.0721
Onchocerca volvulus		0.0012	0.0334	0.0487
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0012	0.0334	0.0721
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.017	0.017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.017	0.0378
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0012	0.0334	0.0721
Brugia malayi	larval opioid receptor	0.0012	0.0334	0.0721
Brugia malayi	hypothetical protein	0.0012	0.0334	0.0721
Echinococcus granulosus	tm gpcr rhodopsin	0.0012	0.0334	0.0334
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.017	0.0366
Echinococcus granulosus	rhodopsin orphan GPCR	0.0012	0.0334	0.0334
Echinococcus multilocularis	g protein coupled receptor	0.0012	0.0334	0.0334
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0012	0.0334	0.0334
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.1789	0.1789
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.017	0.0366
Echinococcus granulosus	g protein coupled receptor	0.0012	0.0334	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0079	0.4497	1
Schistosoma mansoni	hypothetical protein	0.0066	0.3685	0.3685
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.017	0.0378
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.017	0.017
Brugia malayi	Dopamine receptor	0.0012	0.0334	0.0721
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0012	0.0334	0.0334
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0012	0.0334	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0041	0.2134	0.4746
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.017	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Brugia malayi	Serotonin receptor	0.0012	0.0334	0.0721
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0334	0.0743
Brugia malayi	neuropeptide F receptor	0.0012	0.0334	0.0721
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.017	0.017
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0751	0.0751
Echinococcus granulosus	voltage gated potassium channel	0.001	0.0205	0.0205
Brugia malayi	steroid hormone receptor	0.001	0.017	0.0366

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 3.5481 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1461101

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1314695