Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 0.2149 | 0.2149 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0284 | 0.0284 |
Giardia lamblia | Serine peptidase, putative | 0.0491 | 0.2149 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0491 | 0.2149 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0284 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2247 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0491 | 0.2149 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0601 | 0.0601 |
Trypanosoma cruzi | putative prolyl carboxypeptidase, putative | 0.0491 | 0.2149 | 0.5 |
Trichomonas vaginalis | prolylcarboxypeptidase, putative | 0.0491 | 0.2149 | 0.5 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0491 | 0.2149 | 0.2149 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.2247 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0284 | 0.0284 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0491 | 0.2149 | 0.2149 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0491 | 0.2149 | 0.2149 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0491 | 0.2149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2247 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2247 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0491 | 0.2149 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0284 | 0.5 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0491 | 0.2149 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0284 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0284 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0601 | 0.0601 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0284 | 0.0284 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0601 | 0.0601 |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | 0.0491 | 0.2149 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Trichomonas vaginalis | lysosomal pro-X carboxypeptidase, putative | 0.0491 | 0.2149 | 0.5 |
Onchocerca volvulus | 0.0491 | 0.2149 | 0.5 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0284 | 0.0284 |
Giardia lamblia | Thymus-specific serine protease precursor | 0.0491 | 0.2149 | 0.5 |
Entamoeba histolytica | serine carboxypeptidase (S28) family protein | 0.0491 | 0.2149 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Brugia malayi | Serine protease Z688.6 precursor | 0.0491 | 0.2149 | 0.2149 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0491 | 0.2149 | 0.2149 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.2247 | 1 | 1 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.2247 | 1 | 1 |
Toxoplasma gondii | serine carboxypeptidase s28 protein | 0.0491 | 0.2149 | 1 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0284 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0491 | 0.2149 | 0.5 |
Trichomonas vaginalis | Clan SC, family S28, unassigned serine peptidase | 0.0491 | 0.2149 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.