Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | like-glycosyltransferase | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0961 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.0961 | 0.3608 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0019 | 0.0071 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0961 | 0.3608 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0961 | 0.3653 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0064 | 0.1768 | 0.6695 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0961 | 1 |
Echinococcus multilocularis | glycosyltransferase protein LARGE2 | 0.0084 | 0.2525 | 0.9593 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0961 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0961 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.0961 | 0.3608 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0961 | 0.3653 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0961 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0019 | 0.0071 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0961 | 0.3608 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0458 | 0.4767 |
Brugia malayi | Glycosyl transferase family 8 protein | 0.0087 | 0.2631 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 8 | 0.0087 | 0.2631 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0872 | 0.3312 |
Echinococcus multilocularis | glycosyltransferase protein LARGE2 | 0.0084 | 0.2525 | 0.9593 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0019 | 0.0071 |
Echinococcus granulosus | glycosyltransferase protein LARGE2 | 0.0084 | 0.2525 | 0.9593 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1606 | 0.6105 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0961 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0961 | 0.3653 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1606 | 0.6105 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0961 | 0.3653 |
Echinococcus granulosus | Glycosyl transferase family 8 | 0.0087 | 0.2631 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0961 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0961 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0458 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0961 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0031 | 0.0466 | 0.1773 |
Brugia malayi | hypothetical protein | 0.002 | 0.0042 | 0.016 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0961 | 0.3653 |
Onchocerca volvulus | 0.0043 | 0.0961 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0961 | 0.3653 |
Schistosoma mansoni | glycosyltransferase-related | 0.0087 | 0.2631 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0961 | 1 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0961 | 0.3653 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0019 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0872 | 0.3312 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0961 | 0.3653 |
Brugia malayi | AT16019p | 0.0022 | 0.0147 | 0.056 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1606 | 0.6105 |
Echinococcus granulosus | Glycosyltransferase protein LARGE1 | 0.0064 | 0.1768 | 0.6695 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0961 | 0.3653 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0458 | 0.4767 |
Echinococcus multilocularis | glycosyltransferase protein LARGE2 | 0.0084 | 0.2525 | 0.9593 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0458 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1606 | 0.6105 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0961 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0872 | 0.3264 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0458 | 0.4767 |
Brugia malayi | hypothetical protein | 0.003 | 0.0458 | 0.1742 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0458 | 0.1742 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0961 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0961 | 0.3653 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0147 | 0.056 |
Echinococcus multilocularis | Glycosyltransferase protein LARGE1 | 0.0064 | 0.1768 | 0.6695 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0961 | 0.3653 |
Onchocerca volvulus | 0.0043 | 0.0961 | 0.5 | |
Loa Loa (eye worm) | glycosyl transferase family 8 protein | 0.0087 | 0.2631 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0961 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0031 | 0.0466 | 0.1773 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0961 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.0961 | 0.5 | |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0961 | 0.3653 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0961 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0961 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0458 | 0.4767 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0961 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 9.37 uM | PubChem BioAssay. Dose response confirmation of small molecule activators of alpha dystroglycan glycosylation. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.0708 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.5012 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1.7783 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (binding) | = 15.8489 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.