TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 251.199 | Formula: C9H9N5O4
H donors: 1 H acceptors: 5 LogP: 0.58 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1cnn2c1ncc(c2N)C(=O)OCC
InChi: 1S/C9H9N5O4/c1-2-18-9(15)5-3-11-8-6(14(16)17)4-12-13(8)7(5)10/h3-4H,2,10H2,1H3
InChiKey: SDNHHEXZEUFKCE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.004	0.0143	0.0237
Schistosoma mansoni	chromobox protein	0.0072	0.056	0.0542
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.0143	0.0123
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0143	0.0123
Schistosoma mansoni	myosin xvIII	0.004	0.0143	0.0123
Schistosoma mansoni	alpha-1 adrenergic receptor	0.004	0.0143	0.0123
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0192	0.0266
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.0564	0.0545
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0102	0.0082
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Echinococcus multilocularis	fmrfamide receptor	0.004	0.0143	0.0123
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0045	0.0048
Schistosoma mansoni	neuropeptide receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0805	1	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.0143	0.0123
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0143	0.0123
Schistosoma mansoni	neuropeptide receptor	0.004	0.0143	0.0123
Schistosoma mansoni	hypothetical protein	0.0032	0.0045	0.0025
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.0143	0.0123
Echinococcus granulosus	tachykinin peptides receptor 99D	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.004	0.0143	0.0123
Schistosoma mansoni	neuropeptide receptor	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Echinococcus granulosus	neuropeptide receptor	0.004	0.0143	0.0123
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0102	0.0082
Onchocerca volvulus		0.0072	0.0564	0.1048
Brugia malayi	Serotonin receptor	0.004	0.0143	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0143	0.0123
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0805	1	1
Brugia malayi	hypothetical protein	0.004	0.0143	0.0237
Brugia malayi	Melatonin receptor type 1A	0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0564	0.0545
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0079	0.0645	0.1204
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0143	0.0123
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.004	0.0143	0.0123
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0152	0.0211
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Schistosoma mansoni	voltage-gated potassium channel	0.0086	0.0738	0.0719
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0433	0.5207	0.5197
Schistosoma mansoni	opsin-like receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Leishmania major	C-8 sterol isomerase-like protein	0.036	0.4275	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0152	0.0211
Schistosoma mansoni	neuropeptide f receptor 76f	0.004	0.0143	0.0123
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0143	0.0123
Brugia malayi	beta-lactamase	0.0072	0.0564	0.1048
Loa Loa (eye worm)	beta-lactamase	0.0072	0.0564	0.0545
Onchocerca volvulus		0.004	0.0143	0.0237
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0564	0.0545
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus multilocularis	neuropeptide s receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.0143	0.0123
Echinococcus granulosus	vesicular acetylcholine transporter	0.0433	0.5207	0.5197
Onchocerca volvulus		0.004	0.0143	0.0237
Echinococcus granulosus	7TM GPCR rhodopsin	0.004	0.0143	0.0123
Schistosoma mansoni	hypothetical protein	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0511	0.0492
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0073	0.0578	0.0803
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Brugia malayi	AKH receptor	0.004	0.0143	0.0237
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0143	0.0123
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.004	0.0143	0.0123
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0564	0.0783
Brugia malayi	hypothetical protein	0.004	0.0143	0.0237
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.004	0.0143	0.0123
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0143	0.0123
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0564	0.0545
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.0143	0.0123
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.036	0.4275	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0192	0.0331
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Brugia malayi	Serotonin receptor	0.004	0.0143	0.0237
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0079	0.0645	0.0626
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0192	0.0266
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.0564	0.0545
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus multilocularis	chromobox protein 1	0.0072	0.056	0.0542
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0143	0.0123
Echinococcus multilocularis	neuropeptide FF receptor 2	0.004	0.0143	0.0123
Echinococcus granulosus	GPCR family 2	0.0032	0.0045	0.0025
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Brugia malayi	putative neuropeptide receptor NPR1	0.004	0.0143	0.0237
Brugia malayi	G protein-coupled receptor	0.004	0.0143	0.0237
Schistosoma mansoni	neuropeptide receptor	0.004	0.0143	0.0123
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0045	0.0025
Echinococcus multilocularis	serotonin receptor	0.0805	1	1
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.036	0.4275	0.8202
Echinococcus multilocularis	G-protein coupled receptor, putative	0.004	0.0143	0.0123
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Schistosoma mansoni	hypothetical protein	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0564	0.0545
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.0939	0.0921
Echinococcus multilocularis	orexin receptor type 2	0.004	0.0143	0.0123
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Schistosoma mansoni	hypothetical protein	0.0032	0.0045	0.0025
Schistosoma mansoni	opsin-like receptor	0.004	0.0143	0.0123
Schistosoma mansoni	adenoreceptor	0.004	0.0143	0.0123
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0287	0.3329	1
Schistosoma mansoni	hypothetical protein	0.0069	0.0525	0.0506
Onchocerca volvulus		0.004	0.0143	0.0237
Schistosoma mansoni	opsin-like receptor	0.004	0.0143	0.0123
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0073	0.0578	0.0803
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.004	0.0143	0.0123
Loa Loa (eye worm)	TYRA-2 protein	0.004	0.0143	0.0123
Echinococcus granulosus	g protein coupled receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0587	0.72	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Brugia malayi	beta-lactamase family protein	0.0072	0.0564	0.1048
Brugia malayi	jmjC domain containing protein	0.0099	0.0905	0.1706
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0587	0.72	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus granulosus	alpha 1A adrenergic receptor	0.004	0.0143	0.0123
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0433	0.5207	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0525	0.0506
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.004	0.0143	0.0123
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0564	0.0783
Schistosoma mansoni	amine GPCR	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Brugia malayi	jmjC domain containing protein	0.0037	0.0102	0.0158
Brugia malayi	follicle stimulating hormone receptor	0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Schistosoma mansoni	voltage-gated potassium channel	0.0086	0.0738	0.0719
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.056	0.0778
Brugia malayi	Dopamine receptor protein 2	0.004	0.0143	0.0237
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0099	0.0905	0.0887
Echinococcus granulosus	7tm_1 domain containing protein	0.004	0.0143	0.0123
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0045	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0045	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0298	0.0278
Echinococcus multilocularis	sex peptide receptor	0.004	0.0143	0.0123
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.0143	0.0123
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0587	0.72	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0462	0.5588	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0143	0.0123
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Schistosoma mansoni	amine GPCR	0.004	0.0143	0.0123
Schistosoma mansoni	histamine h1 receptor	0.004	0.0143	0.0123
Brugia malayi	hypothetical protein	0.004	0.0143	0.0237
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.0564	0.0545
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus granulosus	hypothetical protein	0.004	0.0143	0.0123
Echinococcus granulosus	allatostatin A receptor	0.004	0.0143	0.0123
Brugia malayi	neuropeptide F receptor	0.004	0.0143	0.0237
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.004	0.0143	0.0123
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.004	0.0143	0.0123
Onchocerca volvulus		0.0072	0.0564	0.1048
Brugia malayi	hypothetical protein	0.004	0.0143	0.0237
Trichomonas vaginalis	esterase, putative	0.0072	0.0564	0.0783
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0143	0.0123
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.056	0.0778
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Toxoplasma gondii	ABC1 family protein	0.0072	0.0564	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0184	0.2004	0.1988
Schistosoma mansoni	growth hormone secretagogue receptor	0.004	0.0143	0.0123
Schistosoma mansoni	hypothetical protein	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Onchocerca volvulus		0.004	0.0143	0.0237
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0045	0.0025
Schistosoma mansoni	hypothetical protein	0.0032	0.0045	0.0025
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0143	0.0123
Brugia malayi	neuropeptide F receptor	0.004	0.0143	0.0237
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.004	0.0143	0.0123
Schistosoma mansoni	vesicular acetylcholine transporter	0.0433	0.5207	0.5197
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0564	0.0545
Echinococcus granulosus	chromobox protein 1	0.0072	0.056	0.0542
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Onchocerca volvulus	Neuropeptide F receptor homolog	0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.0143	0.0123
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.004	0.0143	0.0237
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0564	0.0783
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Brugia malayi	sulfakinin receptor protein	0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Giardia lamblia	Fructose-bisphosphate aldolase	0.0587	0.72	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Treponema pallidum	fructose-bisphosphate aldolase	0.0587	0.72	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.004	0.0143	0.0123
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0805	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0525	0.0974
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.0143	0.0123
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.0643	0.0624
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0587	0.72	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.004	0.0143	0.0237
Brugia malayi	GnHR receptor homolog	0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0143	0.0123
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0079	0.0645	0.0626
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.0143	0.0123
Brugia malayi	hypothetical protein	0.004	0.0143	0.0237
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0564	0.0545
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.0939	0.1772
Onchocerca volvulus		0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0564	0.0545
Echinococcus multilocularis	G protein coupled receptor 139	0.004	0.0143	0.0123
Brugia malayi	putative neuropeptide receptor	0.004	0.0143	0.0237
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Schistosoma mansoni	hypothetical protein	0.004	0.0143	0.0123
Echinococcus multilocularis	neuropeptide receptor A26	0.004	0.0143	0.0123
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Brugia malayi	larval opioid receptor	0.004	0.0143	0.0237
Loa Loa (eye worm)	jmjC domain-containing protein	0.0062	0.0434	0.0415
Echinococcus granulosus	fmrfamide receptor	0.004	0.0143	0.0123
Echinococcus granulosus	neuropeptide receptor A26	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Brugia malayi	hypothetical protein	0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.004	0.0152	0.0132
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.0143	0.0123
Schistosoma mansoni	amine GPCR	0.004	0.0143	0.0123
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Loa Loa (eye worm)	melatonin receptor type 1A	0.004	0.0143	0.0123
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0172	0.0153
Echinococcus granulosus	dro:myosuppressin receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Brugia malayi	RE15519p	0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Schistosoma mansoni	chromobox protein	0.0072	0.056	0.0542
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.0143	0.0123
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0564	0.0783
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0045	0.0025
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.0143	0.0123
Echinococcus granulosus	g protein coupled receptor	0.004	0.0143	0.0123
Trypanosoma brucei	C-8 sterol isomerase, putative	0.036	0.4275	1
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0102	0.0082
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus multilocularis	allatostatin A receptor	0.004	0.0143	0.0123
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0152	0.0255
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0587	0.72	0.5
Brugia malayi	Tachykinin-like peptides receptor 99D	0.004	0.0143	0.0237
Plasmodium falciparum	phd finger protein, putative	0.003	0.002	0.5
Loa Loa (eye worm)	hypothetical protein	0.0032	0.004	0.002
Echinococcus granulosus	G protein coupled receptor 139	0.004	0.0143	0.0123
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.0143	0.0123
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.0939	0.1772
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus multilocularis	neuropeptide receptor	0.004	0.0143	0.0123
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.0564	0.1048
Schistosoma mansoni	biogenic amine receptor	0.004	0.0143	0.0123
Onchocerca volvulus		0.0072	0.0564	0.1048
Schistosoma mansoni	biogenic amine receptor	0.004	0.0143	0.0123
Echinococcus granulosus	g protein coupled receptor	0.004	0.0143	0.0123
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.004	0.0143	0.0123
Echinococcus multilocularis	serotonin receptor	0.0805	1	1
Echinococcus multilocularis	g-protein coupled receptor	0.004	0.0143	0.0123
Brugia malayi	Heterochromatin protein 1	0.0072	0.056	0.1042
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.004	0.0143	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0143	0.0123
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.004	0.0143	0.0123
Brugia malayi	beta-lactamase family protein	0.0072	0.0564	0.1048
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.004	0.0143	0.0237
Brugia malayi	ORL1-like opioid receptor	0.004	0.0143	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0143	0.0123
Echinococcus multilocularis	somatostatin receptor	0.004	0.0143	0.0123
Brugia malayi	Dopamine receptor	0.004	0.0143	0.0237
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.004	0.0143	0.0237
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0143	0.0123
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0045	0.0025
Brugia malayi	G protein-coupled receptor F59B2.13	0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.004	0.0143	0.0123
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0143	0.0123
Schistosoma mansoni	hypothetical protein	0.0032	0.0045	0.0025
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0045	0.0025
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Schistosoma mansoni	amine GPCR	0.004	0.0143	0.0123
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.004	0.0143	0.0123
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.0143	0.0123
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0287	0.3329	0.5503
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0143	0.0123
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0587	0.72	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0102	0.0082
Echinococcus multilocularis	neuropeptide receptor	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Echinococcus multilocularis	dro:myosuppressin receptor	0.004	0.0143	0.0123
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.004	0.0143	0.0123
Onchocerca volvulus		0.004	0.0143	0.0237
Brugia malayi	chromobox protein homolog 3	0.004	0.0152	0.0255
Echinococcus multilocularis	chromobox protein 1	0.0072	0.056	0.0542
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0564	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Brugia malayi	G-protein coupled receptor	0.004	0.0143	0.0237
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0587	0.72	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.0143	0.0123
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0079	0.0645	0.0626
Echinococcus granulosus	peptide allatostatin:somatostatin	0.004	0.0143	0.0123
Echinococcus granulosus	orexin receptor type 2	0.004	0.0143	0.0123
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0433	0.5207	0.5197
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0045	0.0025
Onchocerca volvulus		0.0032	0.004	0.0038
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0172	0.0153
Schistosoma mansoni	biogenic amine receptor	0.004	0.0143	0.0123
Brugia malayi	G-protein coupled receptor	0.004	0.0143	0.0237
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0099	0.0905	0.0887
Schistosoma mansoni	amine GPCR	0.004	0.0143	0.0123
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0433	0.5207	1
Echinococcus granulosus	serotonin receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	hypothetical protein	0.004	0.0143	0.0123
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.004	0.0143	0.0123
Loa Loa (eye worm)	heterochromatin protein 1	0.0072	0.056	0.0542
Loa Loa (eye worm)	hypothetical protein	0.036	0.4275	0.4263
Brugia malayi	hypothetical protein	0.004	0.0143	0.0237
Echinococcus granulosus	neuropeptide s receptor	0.004	0.0143	0.0123
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.004	0.0143	0.0123
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0587	0.72	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.004	0.0143	0.0123
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0587	0.72	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.004	0.0143	0.0123
Brugia malayi	hypothetical protein	0.004	0.0143	0.0237
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0102	0.0082
Echinococcus granulosus	neuropeptide receptor	0.004	0.0143	0.0123
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.0143	0.0123
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0287	0.3329	1
Brugia malayi	hypothetical protein	0.004	0.0143	0.0237
Echinococcus granulosus	somatostatin receptor	0.004	0.0143	0.0123
Brugia malayi	Dopamine receptor protein 1	0.004	0.0143	0.0237
Echinococcus granulosus	neuropeptide FF receptor 2	0.004	0.0143	0.0123
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.0143	0.0123
Echinococcus multilocularis	fmrfamide receptor	0.004	0.0143	0.0123
Echinococcus granulosus	chromobox protein 1	0.0072	0.056	0.0542
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.004	0.0143	0.0123
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0587	0.72	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0564	0.0783
Echinococcus granulosus	sex peptide receptor	0.004	0.0143	0.0123
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0564	0.0545
Echinococcus granulosus	g-protein coupled receptor	0.004	0.0143	0.0123
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.004	0.0143	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0939	0.0921

Activities

Activity type	Activity value	Assay description	Source	Reference
Ratio (binding)	0	Relative inhibition of rabbit lung cAMP Phosphodiesterase compared to theophylline (Insoluble)	ChEMBL.	6279841

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 132035