Detailed information for compound 1323354

Basic information

Technical information
  • TDR Targets ID: 1323354
  • Name: 2-[(2,4,6-trimethylphenyl)amino]pyridine-3-ca rboxylic acid
  • MW: 256.3 | Formula: C15H16N2O2
  • H donors: 2 H acceptors: 3 LogP: 3.9 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c(c(c1)C)Nc1ncccc1C(=O)O
  • InChi: 1S/C15H16N2O2/c1-9-7-10(2)13(11(3)8-9)17-14-12(15(18)19)5-4-6-16-14/h4-8H,1-3H3,(H,16,17)(H,18,19)
  • InChiKey: OKVJKWMXVQISOY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2,4,6-trimethylphenyl)amino]-3-pyridinecarboxylic acid
  • 2-[(2,4,6-trimethylphenyl)amino]nicotinic acid
  • 2-(2,4,6-Trimethyl-phenylamino)-nicotinic acid
  • ASN 04881962
  • MLS000714472
  • SMR000274451

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni lamin 0.0033 0.0186 0.0672
Mycobacterium ulcerans DNA topoisomerase I 0.0039 0.0316 0.0316
Plasmodium falciparum DNA gyrase subunit B 0.0551 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0396 0.1973
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0396 0.0708
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0396 0.1973
Loa Loa (eye worm) hypothetical protein 0.0089 0.1262 0.3835
Entamoeba histolytica DNA topoisomerase III, putative 0.0039 0.0316 0.1574
Echinococcus granulosus lamin dm0 0.0033 0.0186 0.0566
Schistosoma mansoni hypothetical protein 0.0043 0.0392 0.1414
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.3291 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0396 0.1973
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0129 0.2008 0.61
Trypanosoma brucei DNA topoisomerase ii 0.0319 0.5598 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0392 0.1191
Brugia malayi DNA topoisomerase III 0.0039 0.0316 0.096
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0396 0.1204
Schistosoma mansoni alpha-glucosidase 0.0169 0.2773 1
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0186 0.0566
Echinococcus multilocularis lamin 0.0033 0.0186 0.0566
Trypanosoma brucei glucosidase, putative 0.0044 0.0396 0.0708
Trypanosoma cruzi DNA topoisomerase II, putative 0.0089 0.1262 0.2254
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0392 0.1414
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0396 0.1973
Trypanosoma brucei DNA topoisomerase III, putative 0.0039 0.0316 0.0565
Trichomonas vaginalis DNA topoisomerase II, putative 0.0129 0.2008 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0129 0.2008 0.3586
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0089 0.1262 0.2254
Schistosoma mansoni DNA topoisomerase II 0.0129 0.2008 0.724
Trypanosoma cruzi DNA topoisomerase III, putative 0.0039 0.0316 0.0565
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0396 0.1204
Echinococcus multilocularis musashi 0.0033 0.0186 0.0566
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0551 1 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0089 0.1262 0.2254
Brugia malayi GRF zinc finger family protein 0.0039 0.0316 0.096
Echinococcus granulosus lamin 0.0033 0.0186 0.0566
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0129 0.2008 0.61
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0039 0.0316 0.0565
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0039 0.0316 0.1574
Echinococcus multilocularis lamin dm0 0.0033 0.0186 0.0566
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0039 0.0316 0.096
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0396 0.1204
Trypanosoma cruzi DNA topoisomerase III, putative 0.0039 0.0316 0.0565
Leishmania major DNA topoisomerase ii 0.0089 0.1262 0.2254
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0392 0.1191
Entamoeba histolytica DNA topoisomerase III, putative 0.0039 0.0316 0.1574
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.3291 1
Plasmodium falciparum DNA topoisomerase 2 0.0129 0.2008 0.2008
Plasmodium vivax DNA topoisomerase 3, putative 0.0039 0.0316 0.0316
Entamoeba histolytica hypothetical protein 0.0043 0.0392 0.1953
Entamoeba histolytica DNA topoisomerase II, putative 0.0129 0.2008 1
Onchocerca volvulus 0.0039 0.0316 0.0712
Echinococcus granulosus intermediate filament protein 0.0033 0.0186 0.0566
Schistosoma mansoni intermediate filament proteins 0.0033 0.0186 0.0672
Loa Loa (eye worm) TOPoisomerase family member 0.0129 0.2008 0.61
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0396 0.0708
Toxoplasma gondii DNA topoisomerase family protein 0.0039 0.0316 0.0565
Wolbachia endosymbiont of Brugia malayi topoisomerase IA, TopA 0.0039 0.0316 0.0316
Echinococcus multilocularis rho GTPase activating protein 20 0.0039 0.0316 0.096
Plasmodium falciparum DNA topoisomerase 3, putative 0.0039 0.0316 0.0316
Loa Loa (eye worm) hypothetical protein 0.0033 0.0186 0.0566
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0319 0.5598 1
Brugia malayi intermediate filament protein 0.0033 0.0186 0.0566
Entamoeba histolytica hypothetical protein 0.0043 0.0392 0.1953
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0396 0.1973
Leishmania major mitochondrial DNA topoisomerase II 0.0319 0.5598 1
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0551 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0396 0.0708
Plasmodium vivax DNA gyrase subunit B, putative 0.0551 1 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.3291 1
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0039 0.0316 0.114
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0129 0.2008 1
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0186 0.0566
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0396 0.1973
Schistosoma mansoni lamin 0.0033 0.0186 0.0672
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0319 0.5598 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.3291 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0039 0.0316 0.0565
Treponema pallidum DNA topoisomerase I (topA) 0.0039 0.0316 0.0316
Schistosoma mansoni alpha glucosidase 0.0044 0.0396 0.1428
Giardia lamblia DNA topoisomerase II 0.0112 0.1681 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0396 0.1204
Onchocerca volvulus 0.0114 0.1723 0.8434
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0551 1 1
Leishmania major DNA topoisomerase 1A 0.0039 0.0316 0.0565
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0039 0.0316 0.096
Mycobacterium ulcerans DNA gyrase subunit B 0.0551 1 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0129 0.2008 0.61
Brugia malayi Probable DNA topoisomerase II 0.0129 0.2008 0.61
Leishmania major DNA topoisomerase III, putative 0.0039 0.0316 0.0565
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0089 0.1262 0.2254
Trypanosoma cruzi DNA topoisomerase III, putative 0.0039 0.0316 0.0565
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0039 0.0316 0.1574
Brugia malayi hypothetical protein 0.0043 0.0392 0.1191
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0396 0.0708
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0129 0.2008 0.61
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0039 0.0316 0.0565
Loa Loa (eye worm) DNA topoisomerase III 0.0039 0.0316 0.096
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0396 0.1973
Entamoeba histolytica hypothetical protein 0.0043 0.0392 0.1953
Trypanosoma brucei DNA topoisomerase IA, putative 0.0039 0.0316 0.0565
Schistosoma mansoni alpha-glucosidase 0.0169 0.2773 1
Loa Loa (eye worm) hypothetical protein 0.0089 0.1262 0.3835
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0039 0.0316 0.096
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.019 0.3161 1
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0039 0.0316 0.114
Trypanosoma brucei DNA topoisomerase III, putative 0.0039 0.0316 0.0565
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0129 0.2008 1
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0319 0.5598 1
Brugia malayi DNA topoisomerase III beta-1 0.0039 0.0316 0.096
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0396 0.1973
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.3291 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0396 0.1973
Giardia lamblia DNA topoisomerase III 0.0039 0.0316 0.1881
Giardia lamblia DNA topoisomerase III 0.0039 0.0316 0.1881
Plasmodium vivax DNA topoisomerase II, putative 0.0129 0.2008 0.2008
Chlamydia trachomatis DNA gyrase subunit B 0.0362 0.6409 0.6292
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0186 0.0566
Entamoeba histolytica hypothetical protein 0.0043 0.0392 0.1953
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0396 0.1973
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0396 0.1973
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0532
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0129 0.2008 1
Leishmania major DNA topoisomerase III, putative 0.0039 0.0316 0.0565
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0039 0.0316 0.096

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0045 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.0089 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.6109 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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