Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | geminin | 0.0205 | 0.1837 | 0.2703 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0397 | 0.4067 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0357 | 0.3605 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0397 | 0.4067 | 0.5 |
Chlamydia trachomatis | oxoacyl-ACP synthase III | 0.0357 | 0.3605 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1837 | 0.2703 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0133 | 0.101 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0046 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0133 | 0.101 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0133 | 0.101 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0133 | 0.101 | 0.0864 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0046 | 0 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0357 | 0.3605 | 0.5 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0397 | 0.4067 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1837 | 0.2703 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0046 | 0 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0046 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1837 | 0.2703 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0357 | 0.3605 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0357 | 0.3605 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0046 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0397 | 0.4067 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0397 | 0.4067 | 0.397 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0357 | 0.3605 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0397 | 0.4067 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0357 | 0.3605 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.3923 | 0.9631 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0133 | 0.101 | 0.5 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0645 | 0.0493 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0357 | 0.3605 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0645 | 0.1241 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0133 | 0.101 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0133 | 0.101 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8356 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.