Detailed information for compound 1323961

Basic information

Technical information
  • TDR Targets ID: 1323961
  • Name: N-[2-(3,4-dimethoxyphenyl)ethyl]-3,6-dimethyl -1-(4-methylphenyl)pyrazolo[5,4-b]pyridine-4- carboxamide
  • MW: 444.526 | Formula: C26H28N4O3
  • H donors: 1 H acceptors: 3 LogP: 4.83 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)CCNC(=O)c1cc(C)nc2c1c(C)nn2c1ccc(cc1)C
  • InChi: 1S/C26H28N4O3/c1-16-6-9-20(10-7-16)30-25-24(18(3)29-30)21(14-17(2)28-25)26(31)27-13-12-19-8-11-22(32-4)23(15-19)33-5/h6-11,14-15H,12-13H2,1-5H3,(H,27,31)
  • InChiKey: WGERTVCCTAMUCG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(3,4-dimethoxyphenyl)ethyl]-3,6-dimethyl-1-(4-methylphenyl)-4-pyrazolo[5,4-b]pyridinecarboxamide
  • E981-1816
  • NCGC00127477-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans divalent cation-transport integral membrane protein 0.0045 0.1282 0.0164
Mycobacterium ulcerans manganese transport protein MntH 0.0117 0.3987 1
Mycobacterium leprae DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) 0.0072 0.2316 1
Mycobacterium ulcerans divalent cation-transport integral membrane protein 0.0045 0.1282 0.0164
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.1237 0.5
Brugia malayi beta-lactamase family protein 0.0043 0.1237 0.3104
Echinococcus granulosus divalent metal transporter DMT1B 0.0117 0.3987 1
Brugia malayi NRAMP-like transporter K11G12.4 0.0117 0.3987 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.3987 1
Plasmodium vivax metal transporter, putative 0.0117 0.3987 1
Plasmodium falciparum transporter, putative 0.0117 0.3987 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1237 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.1237 0.3104
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1237 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1237 0.5
Brugia malayi beta-lactamase 0.0043 0.1237 0.3104
Schistosoma mansoni divalent metal transporter DMT1B 0.0117 0.3987 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1237 0.3104
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1237 0.3104
Brugia malayi beta-lactamase family protein 0.0043 0.1237 0.3104
Leishmania major hypothetical protein, conserved 0.0043 0.1237 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1237 0.3104
Loa Loa (eye worm) hypothetical protein 0.0043 0.1237 0.3104
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1237 0.5
Toxoplasma gondii divalent metal transporter, putative 0.0117 0.3987 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1237 0.5
Onchocerca volvulus Protein Malvolio homolog 0.0117 0.3987 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1237 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.1237 0.3104
Onchocerca volvulus 0.0043 0.1237 0.3104
Loa Loa (eye worm) beta-lactamase 0.0043 0.1237 0.3104
Onchocerca volvulus 0.0043 0.1237 0.3104
Echinococcus multilocularis divalent metal transporter DMT1B 0.0117 0.3987 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1237 0.3104
Loa Loa (eye worm) hypothetical protein 0.0043 0.1237 0.3104
Trichomonas vaginalis esterase, putative 0.0043 0.1237 0.5
Onchocerca volvulus 0.0043 0.1237 0.3104
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1237 0.3104
Schistosoma mansoni divalent metal transporter DMT1B 0.0117 0.3987 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1237 0.3104
Loa Loa (eye worm) hypothetical protein 0.0043 0.1237 0.3104
Mycobacterium leprae possible membrane transport protein 0.0045 0.1282 0.0417
Loa Loa (eye worm) hypothetical protein 0.0117 0.3987 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1237 0.3104
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1237 0.5
Mycobacterium tuberculosis Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) 0.0072 0.2316 0.1231

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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