Detailed information for compound 1331488

Basic information

Technical information
  • TDR Targets ID: 1331488
  • Name: 2-(2-hydroxyphenyl)isoindole-1,3-dione
  • MW: 239.226 | Formula: C14H9NO3
  • H donors: 1 H acceptors: 3 LogP: 2.1 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccccc1N1C(=O)c2c(C1=O)cccc2
  • InChi: 1S/C14H9NO3/c16-12-8-4-3-7-11(12)15-13(17)9-5-1-2-6-10(9)14(15)18/h1-8,16H
  • InChiKey: JLBSEGLKCFPNGS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-hydroxyphenyl)isoindoline-1,3-dione
  • 2-(2-hydroxyphenyl)isoindoline-1,3-quinone
  • 6307-13-7
  • EU-0060300
  • AIDS-077396
  • AIDS077396
  • Phthalimide, N-(O-hydroxy-phenyl)-
  • CBDivE_003998
  • Oprea1_730869
  • ZINC00148440
  • NSC41070
  • SBB015944

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania mexicana pyruvate kinase, putative Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium falciparum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium parvum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Giardia lamblia Pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum Pyruvate kinase isozyme R, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania infantum pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Theileria parva pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1 Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium tuberculosis Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium knowlesi pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma japonicum ko:K00873 pyruvate kinase [EC2.7.1.40], putative Get druggable targets OG5_126685 All targets in OG5_126685
Neospora caninum Pyruvate kinase (EC 2.7.1.40), related Get druggable targets OG5_126685 All targets in OG5_126685
Schistosoma mansoni pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania mexicana pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, muscle isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Brugia malayi Pyruvate kinase, M2 isozyme Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania donovani pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium berghei pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Toxoplasma gondii pyruvate kinase PyK1 Get druggable targets OG5_126685 All targets in OG5_126685
Candida albicans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium leprae Probable pyruvate kinase PykA Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Mycobacterium ulcerans pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus multilocularis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium yoelii pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Plasmodium vivax pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Cryptosporidium hominis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Trichomonas vaginalis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania braziliensis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Entamoeba histolytica pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma cruzi pyruvate kinase 2, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) pyruvate kinase-PB Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma congolense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Echinococcus granulosus pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Babesia bovis pyruvate kinase, putative Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Chlamydia trachomatis pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
Onchocerca volvulus Pyruvate kinase homolog Get druggable targets OG5_126685 All targets in OG5_126685
Trypanosoma brucei gambiense pyruvate kinase 1, putative Get druggable targets OG5_126685 All targets in OG5_126685
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126685 All targets in OG5_126685
Leishmania major pyruvate kinase Get druggable targets OG5_126685 All targets in OG5_126685
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyruvate kinase pyruvate kinase, putative 498 aa 515 aa 27.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.3278 0.428
Trypanosoma brucei hypothetical protein, conserved 0.0425 0.3575 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0075 0.0248 0.0756
Echinococcus multilocularis GPCR, family 2 0.0197 0.1405 0.4287
Loa Loa (eye worm) TAR-binding protein 0.0392 0.3256 0.3085
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0295 0.0826
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0337 0.2734 0.8341
Onchocerca volvulus 0.0363 0.2978 0.4006
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.3278 0.428
Brugia malayi MH1 domain containing protein 0.0075 0.0248 0.0236
Trypanosoma cruzi polo-like protein kinase, putative 0.0394 0.3278 0.9169
Echinococcus granulosus TGF beta signal transducer SmadC 0.0075 0.0248 0.0756
Loa Loa (eye worm) MH2 domain-containing protein 0.1102 1 1
Brugia malayi MH2 domain containing protein 0.0075 0.0248 0.0236
Schistosoma mansoni hypothetical protein 0.0337 0.2734 0.3355
Loa Loa (eye worm) pip kinase 2 0.0363 0.2978 0.2799
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0295 1
Loa Loa (eye worm) glutaminase 0.0855 0.7659 0.76
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0363 0.2978 0.9084
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.008 0.0295 0.0826
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0197 0.1405 0.4287
Brugia malayi serine/threonine-protein kinase plk-2 0.0394 0.3278 0.327
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.1388 0.1812
Schistosoma mansoni serine/threonine protein kinase 0.0394 0.3278 0.4088
Schistosoma mansoni hypothetical protein 0.0197 0.1405 0.1562
Schistosoma mansoni tar DNA-binding protein 0.0392 0.3256 0.4059
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0197 0.1405 0.1394
Trypanosoma cruzi hypothetical protein, conserved 0.0425 0.3575 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0197 0.1405 0.4287
Schistosoma mansoni transcription factor LCR-F1 0.0337 0.2734 0.3355
Trichomonas vaginalis CAMK family protein kinase 0.0195 0.1388 0.1812
Brugia malayi Pip kinase protein 2 0.0363 0.2978 0.2969
Echinococcus multilocularis Smad4 0.0075 0.0248 0.0756
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.008 0.0295 0.0901
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.3278 0.428
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0363 0.2978 0.3683
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.008 0.0295 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.008 0.0295 1
Giardia lamblia Kinase, PLK 0.0394 0.3278 0.5
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.008 0.0295 0.0901
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0197 0.1405 0.4287
Loa Loa (eye worm) hypothetical protein 0.0078 0.0275 0.0028
Entamoeba histolytica serine/threonine protein kinase, putative 0.0394 0.3278 1
Brugia malayi Isocitrate dehydrogenase 0.008 0.0295 0.0283
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0275 0.0768
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0394 0.3278 1
Mycobacterium ulcerans glutaminase 0.0855 0.7659 1
Schistosoma mansoni tar DNA-binding protein 0.0392 0.3256 0.4059
Loa Loa (eye worm) latrophilin receptor protein 2 0.0197 0.1405 0.1187
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.008 0.0295 1
Brugia malayi Latrophilin receptor protein 2 0.0197 0.1405 0.1394
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0295 0.0901
Leishmania major hypothetical protein, conserved 0.0425 0.3575 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0363 0.2978 0.3683
Brugia malayi glutaminase DH11.1 0.0855 0.7659 0.7657
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.3278 0.428
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0394 0.3278 1
Loa Loa (eye worm) hypothetical protein 0.0622 0.5446 0.533
Brugia malayi latrophilin 2 splice variant baaae 0.0425 0.3576 0.3568
Brugia malayi MH2 domain containing protein 0.0075 0.0248 0.0236
Brugia malayi RNA recognition motif domain containing protein 0.0392 0.3256 0.3248
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0337 0.2734 0.8341
Echinococcus granulosus tar DNA binding protein 0.0392 0.3256 0.9933
Loa Loa (eye worm) hypothetical protein 0.0425 0.3576 0.3412
Brugia malayi TAR-binding protein 0.0392 0.3256 0.3248
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0622 0.5446 0.533
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.0295 1
Schistosoma mansoni tar DNA-binding protein 0.0392 0.3256 0.4059
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0295 0.0901
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0197 0.1405 0.4287
Echinococcus multilocularis tar DNA binding protein 0.0392 0.3256 0.9933
Brugia malayi Smad1 0.0075 0.0248 0.0236
Echinococcus granulosus Smad4 0.0075 0.0248 0.0756
Schistosoma mansoni hypothetical protein 0.0197 0.1405 0.1562
Schistosoma mansoni tar DNA-binding protein 0.0392 0.3256 0.4059
Brugia malayi hypothetical protein 0.0341 0.2777 0.2768
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.0295 0.0901
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.3278 0.428
Schistosoma mansoni glutaminase 0.0855 0.7659 1
Schistosoma mansoni kinase 0.02 0.1437 0.1605
Echinococcus multilocularis isocitrate dehydrogenase 0.008 0.0295 0.0901
Brugia malayi hypothetical protein 0.0337 0.2734 0.2725
Echinococcus granulosus GPCR family 2 0.0197 0.1405 0.4287
Leishmania major hypothetical protein, conserved 0.0078 0.0275 0.0768
Trypanosoma brucei polo-like protein kinase 0.0394 0.3278 0.9099
Schistosoma mansoni hypothetical protein 0.0197 0.1405 0.1562
Schistosoma mansoni hypothetical protein 0.0425 0.3576 0.449
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0295 0.0826
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0394 0.3278 0.3107
Brugia malayi hypothetical protein 0.0078 0.0275 0.0263
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0363 0.2978 0.9084
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0622 0.5446 0.544
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0392 0.3256 0.3085
Trypanosoma cruzi hypothetical protein, conserved 0.0425 0.3575 1
Loa Loa (eye worm) hypothetical protein 0.0363 0.2978 0.2799
Brugia malayi RNA binding protein 0.0392 0.3256 0.3248
Brugia malayi isocitrate dehydrogenase 0.008 0.0295 0.0283
Schistosoma mansoni hypothetical protein 0.0197 0.1405 0.1562
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.3278 0.428
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0275 0.0768
Brugia malayi MH1 domain containing protein 0.0075 0.0248 0.0236
Onchocerca volvulus Serine\/threonine kinase homolog 0.0394 0.3278 1
Loa Loa (eye worm) glutaminase 2 0.0855 0.7659 0.76
Loa Loa (eye worm) hypothetical protein 0.0197 0.1405 0.1187
Trichomonas vaginalis CAMK family protein kinase 0.0394 0.3278 0.428
Loa Loa (eye worm) transcription factor SMAD2 0.1102 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0622 0.5446 0.544
Trichomonas vaginalis glutaminase, putative 0.0855 0.7659 1
Schistosoma mansoni tar DNA-binding protein 0.0392 0.3256 0.4059
Loa Loa (eye worm) hypothetical protein 0.0341 0.2777 0.2594
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0394 0.3278 0.9169
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.0295 0.0063
Trypanosoma brucei isocitrate dehydrogenase, putative 0.008 0.0295 0.0063
Echinococcus granulosus smad 0.0075 0.0248 0.0756
Echinococcus multilocularis smad 0.0075 0.0248 0.0756
Loa Loa (eye worm) isocitrate dehydrogenase 0.008 0.0295 0.0049
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0075 0.0248 0.0756
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.008 0.0295 0.0064
Echinococcus granulosus mothers against decapentaplegic 5 0.0075 0.0248 0.0756
Loa Loa (eye worm) RNA binding protein 0.0392 0.3256 0.3085
Trypanosoma cruzi polo-like protein kinase, putative 0.0394 0.3278 0.9169

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.013 uM PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK): for Probe SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1379, AID1721, AID2266] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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