Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0177 | 0.0177 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0177 | 0.0776 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0276 | 0.2285 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0276 | 0.2285 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0177 | 0.0776 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0276 | 0.2285 | 0.2146 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0892 | 0.0892 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.368 | 0.3566 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0177 | 0.0776 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0177 | 0.0177 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.1006 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0177 | 0.0776 |
Onchocerca volvulus | Deterin homolog | 0.1006 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0276 | 0.2285 | 0.2146 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.368 | 0.3566 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.1006 | 1 | 1 |
Onchocerca volvulus | 0.0276 | 0.2285 | 0.2285 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0177 | 0.0776 |
Loa Loa (eye worm) | hypothetical protein | 0.1006 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0177 | 0.0177 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0892 | 0.0892 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0276 | 0.2285 | 1 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0276 | 0.2285 | 0.2146 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.2285 | 0.2285 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0892 | 0.0728 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.