Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.0347 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0226 | 0.0347 | 0.0436 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0226 | 0.0347 | 0.0436 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0277 | 0.0588 | 0.0588 |
Brugia malayi | cation channel family protein | 0.0974 | 0.3864 | 0.3864 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0821 | 0.3146 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0696 | 0.2559 | 0.2559 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0226 | 0.0347 | 0.0347 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.0347 | 1 |
Schistosoma mansoni | ryanodine receptor 1 skeletal muscle | 0.0263 | 0.0519 | 0.0519 |
Entamoeba histolytica | MIR domain protein | 0.0153 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0588 | 0.0971 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.0347 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1438 | 0.6051 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0226 | 0.0347 | 0.5 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0821 | 0.3146 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0226 | 0.0347 | 0.0573 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0226 | 0.0347 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0558 | 0.1909 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0851 | 0.3286 | 0.543 |
Schistosoma mansoni | hypothetical protein | 0.0562 | 0.1925 | 0.1925 |
Loa Loa (eye worm) | ryanodine receptor | 0.0537 | 0.1812 | 0.2994 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0226 | 0.0347 | 0.0436 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.0589 | 0.5 |
Schistosoma mansoni | ryanodine receptor related | 0.2277 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0226 | 0.0347 | 0.0436 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1438 | 0.6051 | 0.7602 |
Loa Loa (eye worm) | hypothetical protein | 0.0433 | 0.1322 | 0.2184 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1438 | 0.6051 | 0.7602 |
Onchocerca volvulus | 0.0153 | 0 | 0.5 | |
Brugia malayi | MAP kinase sur-1 | 0.0226 | 0.0347 | 0.0347 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.1844 | 0.796 | 1 |
Echinococcus granulosus | ryanodine receptor 44f | 0.1844 | 0.796 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.1237 | 0.2045 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0226 | 0.0347 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.