Detailed information for compound 1338207

Basic information

Technical information
  • TDR Targets ID: 1338207
  • Name: N-[2-(piperidine-1-carbonyl)phenyl]cyclohexan ecarboxamide
  • MW: 314.422 | Formula: C19H26N2O2
  • H donors: 1 H acceptors: 2 LogP: 4.04 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCCCC1)Nc1ccccc1C(=O)N1CCCCC1
  • InChi: 1S/C19H26N2O2/c22-18(15-9-3-1-4-10-15)20-17-12-6-5-11-16(17)19(23)21-13-7-2-8-14-21/h5-6,11-12,15H,1-4,7-10,13-14H2,(H,20,22)
  • InChiKey: QQWTVRICHAMNEP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[2-[oxo-(1-piperidyl)methyl]phenyl]cyclohexanecarboxamide
  • N-(2-piperidin-1-ylcarbonylphenyl)cyclohexanecarboxamide
  • ST5436086
  • ZINC00382031
  • AO-080/42577881
  • MLS000064924
  • N-[2-(1-piperidinylcarbonyl)phenyl]cyclohexanecarboxamide
  • SMR000077943

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0264 0.0264
Echinococcus multilocularis thioredoxin glutathione reductase 0.0089 0.2154 0.8639
Leishmania major glyoxalase I,trypanothione-dependent glyoxalase I 0.0049 0.0845 0.2659
Plasmodium falciparum glyoxalase I 0.0049 0.0845 0.3106
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2451 1
Loa Loa (eye worm) 4-hydroxyphenylpyruvate dioxygenase 0.0333 1 1
Mycobacterium ulcerans hypothetical protein 0.0049 0.0845 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0226 0.6538 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0049 0.0845 0.0927
Treponema pallidum NADH oxidase 0.0031 0.0264 0.5
Toxoplasma gondii glyoxalase family protein 0.0049 0.0845 0.3106
Toxoplasma gondii glyoxalase I, putative 0.0049 0.0845 0.3106
Mycobacterium tuberculosis Cadmium inducible protein CadI 0.0049 0.0845 0.0927
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.0264 0.5
Mycobacterium ulcerans glyoxalase GloA 0.0049 0.0845 1
Giardia lamblia Kinase, PLK 0.0099 0.2451 1
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0049 0.0845 0.2659
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0845 0.2659
Loa Loa (eye worm) glutathione reductase 0.0089 0.2137 0.141
Mycobacterium tuberculosis Probable dehydrogenase 0.0203 0.5808 0.8837
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.2451 1
Trypanosoma cruzi trypanothione reductase, putative 0.0089 0.2137 0.8561
Plasmodium vivax thioredoxin reductase, putative 0.0089 0.2137 1
Plasmodium vivax glyoxalase I, putative 0.0049 0.0845 0.3106
Mycobacterium ulcerans biphenyl-2,3-diol 1,2-dioxygenase 0.0049 0.0845 1
Trypanosoma cruzi lactoylglutathione lyase-like protein, putative 0.0049 0.0845 0.2659
Mycobacterium tuberculosis Conserved protein 0.0049 0.0845 0.0927
Onchocerca volvulus Serine\/threonine kinase homolog 0.0099 0.2451 0.1754
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0226 0.6538 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2451 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0203 0.5808 0.8837
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2451 1
Toxoplasma gondii thioredoxin reductase 0.0089 0.2137 1
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0845 0.2658
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0099 0.2451 1
Plasmodium falciparum thioredoxin reductase 0.0089 0.2137 1
Brugia malayi glutathione reductase 0.0089 0.2137 0.2137
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0203 0.5808 0.8718
Mycobacterium ulcerans hypothetical protein 0.0049 0.0845 1
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0845 0.2658
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2451 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0089 0.2137 0.2985
Mycobacterium ulcerans hypothetical protein 0.0049 0.0845 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2451 1
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2451 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0099 0.2451 0.5
Mycobacterium ulcerans hypothetical protein 0.0049 0.0845 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0845 0.2659
Plasmodium vivax glutathione reductase, putative 0.0089 0.2137 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0203 0.5808 0.8837
Schistosoma mansoni gynecophoral canal protein 0.0049 0.0845 0.0713
Trypanosoma brucei polo-like protein kinase 0.0099 0.2451 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0031 0.0264 0.5
Mycobacterium ulcerans hypothetical protein 0.0049 0.0845 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0099 0.2451 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0203 0.5808 0.8837
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.0264 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0099 0.2451 1
Mycobacterium tuberculosis Probable reductase 0.0203 0.5808 0.8837
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0099 0.2451 1
Mycobacterium tuberculosis Conserved protein TB27.3 0.0049 0.0845 0.0927
Mycobacterium ulcerans glyoxalase GloA 0.0049 0.0845 1
Plasmodium falciparum glutathione reductase 0.0089 0.2137 1
Schistosoma mansoni 4-hydroxyphenylpyruvate dioxygenase 0.0049 0.0845 0.0713
Plasmodium vivax glyoxalase I, putative 0.0049 0.0845 0.3106
Leishmania major trypanothione reductase 0.0089 0.2137 0.8561
Mycobacterium tuberculosis Conserved protein 0.0049 0.0845 0.0927
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0226 0.6538 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0099 0.2451 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0099 0.2451 0.2451
Plasmodium falciparum glyoxalase I 0.0049 0.0845 0.3106
Onchocerca volvulus Putative protein 0.0333 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0203 0.5808 0.8837
Loa Loa (eye worm) thioredoxin reductase 0.0089 0.2137 0.141
Trypanosoma brucei trypanothione reductase 0.0089 0.2137 0.8561
Mycobacterium ulcerans hypothetical protein 0.0049 0.0845 1
Schistosoma mansoni kinase 0.005 0.0887 0.0764
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.2451 0.268
Brugia malayi Thioredoxin reductase 0.0089 0.2137 0.2137
Echinococcus granulosus thioredoxin glutathione reductase 0.0089 0.2154 0.8639
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0226 0.6538 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0099 0.2451 0.1754
Brugia malayi lactoylglutathione lyase 0.0049 0.0845 0.0845

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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