Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Toxoplasma gondii | histone lysine methyltransferase SET1 | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Neospora caninum | Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma japonicum | ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | Get druggable targets OG5_130642 | All targets in OG5_130642 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0007 | 0.0005 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3383 | 0.8375 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1971 | 0.4871 | 0.487 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4038 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.1971 | 0.4871 | 0.487 |
Echinococcus multilocularis | carbonic anhydrase | 0.1971 | 0.4871 | 0.487 |
Mycobacterium ulcerans | carbonic anhydrase | 0.3509 | 0.8688 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0007 | 0.0005 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1971 | 0.4871 | 0.4867 |
Schistosoma mansoni | carbonic anhydrase | 0.3509 | 0.8688 | 0.8688 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0067 | 0.006 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1971 | 0.4871 | 0.487 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.2108 | 0.5211 | 0.8683 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1971 | 0.4871 | 0.4867 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1971 | 0.4871 | 0.4867 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0067 | 0.0065 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0071 | 0.007 |
Echinococcus granulosus | carbonic anhydrase | 0.1971 | 0.4871 | 0.487 |
Leishmania major | carbonic anhydrase-like protein | 0.4038 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2595 | 0.642 | 0.6417 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0071 | 0.007 |
Echinococcus multilocularis | carbonic anhydrase II | 0.4038 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1971 | 0.4871 | 0.487 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.4038 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1971 | 0.4871 | 0.4867 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0067 | 0.0059 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.2234 | 0.5524 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1971 | 0.4871 | 0.4867 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0071 | 0.007 |
Schistosoma mansoni | carbonic anhydrase | 0.1971 | 0.4871 | 0.487 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.4038 | 1 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1971 | 0.4871 | 0.4867 |
Loa Loa (eye worm) | hypothetical protein | 0.1971 | 0.4871 | 0.4867 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1971 | 0.4871 | 0.487 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.4038 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1971 | 0.4871 | 0.487 |
Echinococcus granulosus | carbonic anhydrase | 0.1971 | 0.4871 | 0.487 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.0163 | 0.0161 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0071 | 0.007 |
Echinococcus multilocularis | carbonic anhydrase | 0.1971 | 0.4871 | 0.487 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1971 | 0.4871 | 0.4867 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.4038 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4038 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.4038 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.4038 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.3509 | 0.8688 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.4038 | 1 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.0067 | 0.5 | |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.3509 | 0.8688 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3383 | 0.8375 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.1971 | 0.4871 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1971 | 0.4871 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 2377.8108 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.