Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.4211 | 0.4211 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide | 0.0217 | 0.3425 | 0.8134 |
Trypanosoma cruzi | endonuclease G, putative | 0.0155 | 0.2216 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Onchocerca volvulus | 0.0557 | 1 | 1 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Echinococcus granulosus | Endonuclease G | 0.0155 | 0.2216 | 0.5262 |
Schistosoma mansoni | endonuclease related | 0.0155 | 0.2216 | 0.2216 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0557 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0557 | 1 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0155 | 0.2216 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0258 | 0.4211 | 0.4211 |
Trypanosoma brucei | endonuclease G, putative | 0.0155 | 0.2216 | 1 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0041 | 0 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0155 | 0.2216 | 1 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0258 | 0.4211 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.3425 | 0.3425 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0258 | 0.4211 | 0.4211 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0155 | 0.2216 | 1 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0041 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0258 | 0.4211 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.4211 | 0.4211 |
Mycobacterium leprae | hypothetical protein | 0.0041 | 0 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0258 | 0.4211 | 0.4211 |
Echinococcus multilocularis | Endonuclease G | 0.0155 | 0.2216 | 0.5262 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.4211 | 0.4211 |
Echinococcus multilocularis | ectonucleotide | 0.0217 | 0.3425 | 0.8134 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0155 | 0.2216 | 0.2216 |
Onchocerca volvulus | 0.0258 | 0.4211 | 0.4211 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0155 | 0.2216 | 0.5 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0155 | 0.2216 | 0.5 |
Entamoeba histolytica | phosphatidylinositol-glycan biosynthesis class O protein, putative | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0155 | 0.2216 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Plasmodium falciparum | GPI ethanolamine phosphate transferase 3, putative | 0.0041 | 0 | 0.5 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0155 | 0.2216 | 1 |
Leishmania major | endonuclease G, putative | 0.0155 | 0.2216 | 1 |
Onchocerca volvulus | 0.0258 | 0.4211 | 0.4211 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0217 | 0.3425 | 0.8134 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0258 | 0.4211 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0217 | 0.3425 | 0.8134 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.005 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.