Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0024 | 0.037 | 0.0795 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0079 | 0.3554 | 0.3554 |
Schistosoma mansoni | alkaline phosphatase | 0.0189 | 1 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0028 | 0.0573 | 0.0573 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.4366 | 0.4366 |
Brugia malayi | Histone deacetylase family protein | 0.0028 | 0.0573 | 0.123 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0098 | 0.4663 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0052 | 0.1964 | 0.4211 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0052 | 0.1961 | 0.4206 |
Echinococcus granulosus | histone deacetylase 6 | 0.0028 | 0.0573 | 0.0573 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.4366 | 0.4366 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0573 | 0.123 |
Toxoplasma gondii | histone deacetylase HDAC4 | 0.0028 | 0.0573 | 0.123 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0028 | 0.0573 | 0.123 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0028 | 0.0573 | 0.123 |
Schistosoma mansoni | histone deacetylase | 0.0098 | 0.4663 | 0.4663 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0028 | 0.0573 | 0.0573 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0098 | 0.4663 | 1 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0052 | 0.1961 | 0.4206 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0098 | 0.4663 | 1 |
Echinococcus granulosus | histone deacetylase | 0.0028 | 0.0573 | 0.0573 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.0079 | 0.3554 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0079 | 0.3554 | 0.7623 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Giardia lamblia | Histone deacetylase | 0.0098 | 0.4663 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0028 | 0.0573 | 0.0573 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Echinococcus granulosus | histone deacetylase 1 | 0.0098 | 0.4663 | 0.4663 |
Entamoeba histolytica | histone deacetylase, putative | 0.0098 | 0.4663 | 1 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Trypanosoma brucei | histone deacetylase 3 | 0.0028 | 0.0573 | 0.123 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0098 | 0.4663 | 0.4663 |
Trypanosoma brucei | histone deacetylase 4 | 0.0028 | 0.0573 | 0.123 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.0079 | 0.3554 | 1 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0189 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0093 | 0.4366 | 0.9365 |
Leishmania major | histone deacetylase, putative | 0.0098 | 0.4663 | 1 |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.0079 | 0.3554 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0098 | 0.4663 | 1 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.0079 | 0.3554 | 0.7623 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0098 | 0.4663 | 1 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0189 | 1 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0079 | 0.3554 | 0.7623 |
Echinococcus granulosus | alkaline phosphatase | 0.0189 | 1 | 1 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.0024 | 0.037 | 0.0795 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0024 | 0.037 | 0.0795 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.4366 | 0.4366 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0093 | 0.4366 | 0.4366 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0052 | 0.1964 | 0.1964 |
Toxoplasma gondii | histone deacetylase HDAC5 | 0.0028 | 0.0573 | 0.123 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0027 | 0.0532 | 0.1141 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0098 | 0.4663 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0098 | 0.4663 | 1 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0028 | 0.0573 | 0.123 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.0079 | 0.3554 | 0.7623 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0052 | 0.1964 | 0.4211 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0098 | 0.4663 | 1 |
Leishmania major | glyceraldehyde-3-phosphate dehydrogenase-like protein | 0.0052 | 0.1961 | 0.4206 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0079 | 0.3554 | 0.7623 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.4366 | 0.4366 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0079 | 0.3554 | 0.3554 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0098 | 0.4663 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Echinococcus granulosus | histone deacetylase 7 | 0.0028 | 0.0573 | 0.0573 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0055 | 0.2125 | 0.4558 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0079 | 0.3554 | 0.7623 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, cytosolic | 0.0079 | 0.3554 | 0.7623 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0024 | 0.037 | 0.0795 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0098 | 0.4663 | 1 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0028 | 0.0573 | 0.123 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.4663 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0093 | 0.4366 | 0.9365 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0028 | 0.0573 | 0.0573 |
Plasmodium vivax | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Echinococcus granulosus | histone deacetylase 6 | 0.0028 | 0.0573 | 0.0573 |
Plasmodium falciparum | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0052 | 0.1964 | 0.4211 |
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.0079 | 0.3554 | 0.5 |
Brugia malayi | histone deacetylase 11 | 0.0028 | 0.0573 | 0.123 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0189 | 1 | 1 |
Brugia malayi | Histone deacetylase family protein | 0.0028 | 0.0573 | 0.123 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0052 | 0.1961 | 0.4206 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0189 | 1 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0028 | 0.0573 | 0.0573 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Plasmodium falciparum | histone deacetylase 2 | 0.0028 | 0.0573 | 0.123 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0098 | 0.4663 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Echinococcus multilocularis | alkaline phosphatase | 0.0189 | 1 | 1 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0098 | 0.4663 | 1 |
Leishmania major | histone deacetylase, putative | 0.0098 | 0.4663 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0079 | 0.3554 | 0.3554 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0079 | 0.3554 | 0.3554 |
Leishmania major | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0098 | 0.4663 | 1 |
Echinococcus multilocularis | histone deacetylase | 0.0028 | 0.0573 | 0.0573 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0027 | 0.0535 | 1 |
Plasmodium falciparum | histone deacetylase 1 | 0.0098 | 0.4663 | 1 |
Echinococcus granulosus | histone deacetylase 3 | 0.0098 | 0.4663 | 0.4663 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0098 | 0.4663 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0027 | 0.0532 | 0.1141 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0052 | 0.1964 | 0.1964 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0028 | 0.0573 | 0.0573 |
Echinococcus granulosus | histone deacetylase 8 | 0.0028 | 0.0573 | 0.0573 |
Schistosoma mansoni | histone deacetylase | 0.0098 | 0.4663 | 0.4663 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.0052 | 0.1964 | 0.4211 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.0055 | 0.2125 | 0.4558 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0028 | 0.0573 | 0.0573 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Schistosoma mansoni | alkaline phosphatase | 0.0189 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0098 | 0.4663 | 1 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0028 | 0.0573 | 0.0573 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0079 | 0.3554 | 0.3554 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0028 | 0.0573 | 0.0573 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0079 | 0.3554 | 0.7623 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0028 | 0.0573 | 0.0573 |
Brugia malayi | Histone deacetylase 1 | 0.0098 | 0.4663 | 1 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.0079 | 0.3554 | 0.3554 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.0079 | 0.3554 | 0.7623 |
Echinococcus granulosus | histone deacetylase 6 | 0.0028 | 0.0573 | 0.0573 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0027 | 0.0535 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0098 | 0.4663 | 1 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0079 | 0.3554 | 0.7623 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0098 | 0.4663 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.4688 | 0.4688 |
Trypanosoma brucei | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0079 | 0.3554 | 0.7623 |
Loa Loa (eye worm) | histone deacetylase | 0.0028 | 0.0573 | 0.123 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0052 | 0.1961 | 0.4206 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0093 | 0.4366 | 0.4366 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.0079 | 0.3554 | 0.3554 |
Leishmania major | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.0079 | 0.3554 | 0.7623 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.0079 | 0.3554 | 0.7623 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0098 | 0.4663 | 1 |
Trypanosoma brucei | histone deacetylase 2 | 0.0028 | 0.0573 | 0.123 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0093 | 0.4366 | 0.4366 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0189 | 1 | 1 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0028 | 0.0573 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0098 | 0.4663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1964 | 0.4211 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.0024 | 0.037 | 0.0795 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative | 0.0024 | 0.037 | 0.0795 |
Leishmania major | glyceraldehyde 3-phosphate dehydrogenase, glycosomal | 0.0079 | 0.3554 | 0.7623 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0098 | 0.4663 | 0.4663 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.0079 | 0.3554 | 0.3554 |
Plasmodium vivax | histone deacetylase, putative | 0.0028 | 0.0573 | 0.123 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 2 ug ml-1 | Antifungal activity of the compound against Candida pseudotropicalis; Range is 2-4 | ChEMBL. | 2810336 |
MIC (functional) | = 64 ug ml-1 | Antifungal activity of the compound against Aspergillus niger; Range is 64-128 | ChEMBL. | 2810336 |
MIC (functional) | = 64 ug ml-1 | Antifungal activity of the compound against Trychophyton mentagrophytes | ChEMBL. | 2810336 |
MIC (functional) | = 64 ug ml-1 | Antifungal activity against Trychophyton rubrum | ChEMBL. | 2810336 |
MIC (functional) | = 128 ug ml-1 | Antifungal activity of the compound against Candida albicans | ChEMBL. | 2810336 |
MIC (functional) | = 128 ug ml-1 | Antifungal activity of the compound against Candida parapsilosis | ChEMBL. | 2810336 |
MIC (functional) | = 128 ug ml-1 | Antifungal activity of the compound against Candida tropicalis | ChEMBL. | 2810336 |
MIC (functional) | = 128 ug ml-1 | Antifungal activity of the compound against Candida albicans | ChEMBL. | 2810336 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.