Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0.0808 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.2553 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0808 | 0.2561 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3155 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3155 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3155 | 0.2553 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0808 | 0.2561 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.2553 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3155 | 0.2553 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.2553 |
Onchocerca volvulus | 0.0033 | 0.0808 | 0.5 | |
Brugia malayi | RNA binding protein | 0.0076 | 0.3155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0776 | 0.246 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0808 | 0.2561 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0808 | 0.2561 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0808 | 0.2561 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3155 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3155 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.2553 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.2553 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0411 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.9285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.