Detailed information for compound 1353383

Basic information

Technical information
  • TDR Targets ID: 1353383
  • Name: 2-(5,5-dimethyl-2-oxooxolan-3-yl)-N-[(4-nitro phenyl)carbamothioyl]acetamide
  • MW: 351.378 | Formula: C15H17N3O5S
  • H donors: 2 H acceptors: 4 LogP: 2.23 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CC1CC(OC1=O)(C)C)NC(=S)Nc1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C15H17N3O5S/c1-15(2)8-9(13(20)23-15)7-12(19)17-14(24)16-10-3-5-11(6-4-10)18(21)22/h3-6,9H,7-8H2,1-2H3,(H2,16,17,19,24)
  • InChiKey: ORTJRBCICRYFRO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(5,5-dimethyl-2-oxo-tetrahydrofuran-3-yl)-N-[(4-nitrophenyl)carbamothioyl]acetamide
  • 2-(5,5-dimethyl-2-oxo-3-tetrahydrofuranyl)-N-[[(4-nitrophenyl)amino]-thioxomethyl]acetamide
  • 2-(2-keto-5,5-dimethyl-tetrahydrofuran-3-yl)-N-[(4-nitrophenyl)thiocarbamoyl]acetamide
  • 2-(5,5-dimethyl-2-oxo-oxolan-3-yl)-N-[(4-nitrophenyl)carbamothioyl]ethanamide
  • 2-(5,5-dimethyl-2-oxotetrahydro-3-furanyl)-N-{[(4-nitrophenyl)amino]carbonothioyl}acetamide
  • MLS000535188
  • SMR000142624

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0048 0.018 0.0245
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0095 0.1318 0.2244
Onchocerca volvulus DNA polymerase homolog 0.0095 0.1318 0.2242
Loa Loa (eye worm) hypothetical protein 0.0053 0.0301 0.0554
Echinococcus multilocularis voltage dependent calcium channel 0.0189 0.355 0.6447
Brugia malayi thymidylate kinase 0.0078 0.0907 0.147
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0053 0.03 0.0551
Echinococcus multilocularis voltage dependent calcium channel 0.0189 0.355 0.6447
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0053 0.03 0.0468
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0094 0.1289 0.126
Loa Loa (eye worm) hypothetical protein 0.0053 0.03 0.0551
Trypanosoma cruzi thymidylate kinase, putative 0.0078 0.0907 0.1427
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0095 0.1318 0.2244
Brugia malayi Muscleblind-like protein 0.018 0.3352 0.6073
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0189 0.355 0.3467
Loa Loa (eye worm) hypothetical protein 0.0155 0.2735 0.5029
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0095 0.1318 0.2078
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0155 0.2735 0.491
Toxoplasma gondii DNA polymerase 0.0267 0.5438 1
Brugia malayi DNA polymerase family B containing protein 0.0095 0.1318 0.2244
Echinococcus multilocularis muscleblind protein 1 0.018 0.3352 0.6073
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0095 0.1318 0.129
Loa Loa (eye worm) hypothetical protein 0.018 0.3352 0.6164
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0214 0.4168 0.6751
Brugia malayi RNase H family protein 0.0046 0.0127 0.0002
Echinococcus granulosus voltage dependent calcium channel 0.0189 0.355 0.6447
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0104 0.1524 0.1497
Trypanosoma brucei RNA helicase, putative 0.0458 1 1
Brugia malayi RNase H family protein 0.0046 0.0127 0.0002
Brugia malayi RNase H family protein 0.0046 0.0127 0.0002
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.005 0.0225 0.0188
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0267 0.5438 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0104 0.1524 0.274
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0095 0.1318 0.2244
Trichomonas vaginalis DNA polymerase II, putative 0.0104 0.1524 0.274
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0051 0.0254 0.0384
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0095 0.1318 0.129
Onchocerca volvulus Putative thymidylate kinase 0.0078 0.0907 0.1468
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0134 0.2251 0.4002
Schistosoma mansoni voltage-gated cation channel 0.0189 0.355 0.3467
Toxoplasma gondii transporter, cation channel family protein 0.0053 0.0301 0.0471
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0251 0.0358
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0095 0.1318 0.1206
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.2404 0.3855
Toxoplasma gondii ribonuclease HI protein 0.0046 0.0127 0.0147
Trypanosoma brucei thymidylate kinase, putative 0.0078 0.0907 0.0877
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0267 0.5438 0.8824
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0267 0.5438 0.5379
Trypanosoma cruzi ribonuclease H1, putative 0.0046 0.0127 0.0154
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0189 0.355 0.6447
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0267 0.5438 1
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0078 0.0907 1
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0095 0.1318 0.2356
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.2785 1
Loa Loa (eye worm) calcium channel 0.0189 0.355 0.6529
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.6159 1
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0078 0.0907 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.6159 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.355 0.6529
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0189 0.355 0.6447
Plasmodium falciparum thymidylate kinase 0.0078 0.0907 0.1593
Mycobacterium ulcerans hypothetical protein 0.0157 0.2785 1
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0104 0.1524 0.2417
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0189 0.355 0.6447
Echinococcus granulosus thymidylate kinase 0.0078 0.0907 0.147
Echinococcus granulosus voltage dependent calcium channel 0.0053 0.0301 0.0331
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0267 0.5438 0.5423
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.6159 1
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0095 0.1318 0.2098
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.6159 0.6146
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0267 0.5438 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.03 0.0551
Echinococcus multilocularis ribonuclease H1 0.0046 0.0127 0.0002
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0267 0.5438 1
Entamoeba histolytica Thymidylate kinase, putative 0.0078 0.0907 0.1593
Echinococcus multilocularis thymidylate kinase 0.0078 0.0907 0.147
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0267 0.5438 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0189 0.355 0.6447
Echinococcus multilocularis sodium channel protein 0.005 0.0225 0.0188
Trichomonas vaginalis thymidylate kinase, putative 0.0078 0.0907 0.1593
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0189 0.355 0.6447
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0056 0.0375 0.0344
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0104 0.1524 0.2436
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0095 0.1318 0.1206
Chlamydia trachomatis thymidylate kinase 0.0078 0.0907 0.5
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0267 0.5438 1
Loa Loa (eye worm) thymidylate kinase 0.0078 0.0907 0.1667
Trypanosoma brucei ingi protein (ORF1) 0.0056 0.0375 0.0344
Loa Loa (eye worm) hypothetical protein 0.0044 0.0093 0.0171
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0042 0.0048 0.0087
Plasmodium vivax DNA polymerase alpha, putative 0.0124 0.2008 0.243
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0095 0.1318 0.2242
Trichomonas vaginalis ribonuclease H1, putative 0.0046 0.0127 0.0147
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0267 0.5438 1
Giardia lamblia CDC8 0.0078 0.0907 0.1468
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0053 0.03 0.0468
Loa Loa (eye worm) voltage-dependent calcium channel 0.0053 0.0301 0.0554
Giardia lamblia DNA polymerase alpha subunit A 0.0081 0.0981 0.1609
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0134 0.2251 0.2152
Trypanosoma cruzi DNA polymerase zeta catalytic subunit, putative 0.0042 0.0048 0.0025
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0189 0.355 0.3467
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0095 0.1318 0.2244
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0051 0.0254 0.0384
Loa Loa (eye worm) hypothetical protein 0.018 0.3352 0.6164
Trypanosoma brucei ingi protein (ORF1) 0.0056 0.0375 0.0344
Toxoplasma gondii hypothetical protein 0.0044 0.0093 0.0084
Trypanosoma brucei hypothetical protein, conserved 0.0056 0.0375 0.0344
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0094 0.1289 0.2051
Trypanosoma cruzi thymidylate kinase, putative 0.0078 0.0907 0.1427
Echinococcus granulosus muscleblind protein 0.018 0.3352 0.6073
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0213 0.0087
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0267 0.5438 1
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0134 0.2251 0.4002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0093 0.0171
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0267 0.5438 1
Trichomonas vaginalis thymidylate kinase, putative 0.0078 0.0907 0.1593
Treponema pallidum thymidylate kinase (tmk) 0.0078 0.0907 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0267 0.5438 0.8821
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0095 0.1318 0.2098
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0124 0.2008 0.3636
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.2404 0.2379
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0189 0.355 0.6447
Toxoplasma gondii DNA polymerase family B protein 0.0095 0.1318 0.2356
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0046 0.0125 0.0231
Schistosoma mansoni thymidylate kinase 0.0078 0.0907 0.079
Trypanosoma brucei ribonuclease H1 0.0046 0.0127 0.0095
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0095 0.1318 0.2244
Echinococcus multilocularis muscleblind protein 0.018 0.3352 0.6073
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0095 0.1318 0.0907
Schistosoma mansoni hypothetical protein 0.0078 0.0907 0.079
Leishmania major thymidylate kinase-like protein 0.0078 0.0907 0.1406
Loa Loa (eye worm) hypothetical protein 0.0042 0.0048 0.0087
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0189 0.355 0.6447
Trypanosoma brucei thymidylate kinase, putative 0.0078 0.0907 0.0877
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0095 0.1318 0.0907
Toxoplasma gondii thymidylate kinase 0.0078 0.0907 0.1593
Leishmania major ribonuclease H1, putative 0.0046 0.0127 0.013
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0095 0.1318 0.2356
Trypanosoma cruzi ribonuclease H1, putative 0.0046 0.0127 0.0154
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0213 0.0087
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0095 0.1318 0.2242
Loa Loa (eye worm) hypothetical protein 0.0042 0.0048 0.0087
Brugia malayi DNA polymerase alpha catalytic subunit 0.0124 0.2008 0.3543
Schistosoma mansoni thymidylate kinase 0.0078 0.0907 0.079
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0189 0.355 0.6447
Trypanosoma brucei unspecified product 0.0056 0.0375 0.0344
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.2404 0.3871
Echinococcus granulosus ribonuclease H1 0.0046 0.0127 0.0002
Brugia malayi DNA polymerase delta catalytic subunit 0.0267 0.5438 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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