Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | multiple endocrine neoplasia I | No references | |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0014 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0192 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0014 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0025 | 0.0044 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0014 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0115 | 0.5396 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.1843 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0192 | 0.0961 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.2661 | 1 | 0.5 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0122 | 0.0578 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0192 | 0.1028 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0017 | 0.0074 |
Onchocerca volvulus | 0.0035 | 0.0115 | 0.5 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0192 | 0.0961 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.0231 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0014 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0014 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0014 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.2661 | 1 | 0.5 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.2661 | 1 | 0.5 |
Trypanosoma brucei | Enriched in surface-labeled proteome protein 12 | 0.2661 | 1 | 0.5 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.1843 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0192 | 0.0961 |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.1843 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0014 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0192 | 0.1028 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0014 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0115 | 0.0608 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0192 | 0.1028 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0014 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0014 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.2661 | 1 | 0.5 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0014 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0192 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0014 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0014 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.0261 | 0.1403 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0122 | 0.0648 |
Trypanosoma brucei | hypothetical protein, conserved | 0.2661 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0014 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0025 | 0.0044 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0115 | 0.5381 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0014 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0014 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0122 | 0.0578 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0192 | 0.0961 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0122 | 0.0648 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0014 | 1 |
Trypanosoma cruzi | Enriched in surface-labeled proteome protein 12 | 0.2661 | 1 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0014 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.