Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0136 | 0.0987 | 0.2533 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0136 | 0.0987 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.3219 | 1 |
Brugia malayi | hypothetical protein | 0.0237 | 0.2339 | 0.2094 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0144 | 0.1083 | 0.2657 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0303 | 0.3219 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0697 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.031 | 0.031 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0086 | 0.031 | 0.0712 |
Trypanosoma brucei | glucosidase, putative | 0.0136 | 0.0987 | 0.2326 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0136 | 0.0987 | 0.0115 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0811 | 1 | 1 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0129 | 0.0882 | 0.225 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0784 | 0.9645 | 0.9611 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.3219 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0784 | 0.9645 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.076 | 0.9323 | 0.9652 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.1083 | 0.2657 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0136 | 0.0987 | 0.2533 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0811 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0136 | 0.0987 | 0.2326 |
Onchocerca volvulus | Huntingtin homolog | 0.0115 | 0.0697 | 0.0562 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0086 | 0.031 | 0.0712 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0136 | 0.0987 | 0.2533 |
Schistosoma mansoni | alpha-glucosidase | 0.076 | 0.9323 | 0.9652 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0136 | 0.0987 | 0.0115 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0136 | 0.0987 | 0.2533 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0086 | 0.031 | 0.0712 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0237 | 0.2339 | 0.1598 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0784 | 0.9645 | 0.9634 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0136 | 0.0987 | 0.2533 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0136 | 0.0987 | 0.0987 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0144 | 0.1083 | 0.2657 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0136 | 0.0987 | 0.2533 |
Trichomonas vaginalis | glycogen debranching enzyme, putative | 0.0129 | 0.0882 | 0.225 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0344 | 0.3762 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0086 | 0.031 | 0.0712 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0697 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.0882 | 0.0882 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.016 | 0.13 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1372 | 0.1047 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0086 | 0.031 | 0.0712 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0136 | 0.0987 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0086 | 0.031 | 0.0712 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0344 | 0.3762 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0784 | 0.9645 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0136 | 0.0987 | 0.2326 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0759 | 0.9311 | 0.9244 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 0.2339 | 0.2339 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0136 | 0.0987 | 0.2326 |
Brugia malayi | Amylo-alpha-1,6-glucosidase family protein | 0.0129 | 0.0882 | 0.059 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0136 | 0.0987 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0303 | 0.3219 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0136 | 0.0987 | 0.0698 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0811 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0136 | 0.0987 | 0.2533 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0784 | 0.9645 | 0.9645 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0136 | 0.0987 | 0.2533 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0784 | 0.9645 | 0.9611 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0136 | 0.0987 | 0.2533 |
Entamoeba histolytica | glycogen debranching enzyme, putative | 0.0129 | 0.0882 | 0.8449 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0237 | 0.2339 | 0.1598 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0811 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0115 | 0.0697 | 0.0562 |
Schistosoma mansoni | alpha glucosidase | 0.0136 | 0.0987 | 0.063 |
Giardia lamblia | 4-alpha-glucanotransferase, amylo-alpha-1,6-glucosidase | 0.0129 | 0.0882 | 0.5 |
Onchocerca volvulus | 0.06 | 0.7186 | 1 | |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0086 | 0.031 | 0.0712 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0086 | 0.031 | 0.0712 |
Brugia malayi | hypothetical protein | 0.0115 | 0.0697 | 0.0399 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 195 um | PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.