Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0548 | 0.0414 |
Chlamydia trachomatis | glycogen phosphorylase | 0.1095 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.014 | 0.014 |
Schistosoma mansoni | glycogen phosphorylase | 0.1095 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1095 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.0548 | 0.0414 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0473 | 0.4232 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0548 | 0.0414 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.0548 | 0.0548 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.014 | 0.014 |
Schistosoma mansoni | glycogen phosphorylase | 0.1095 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.1095 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.014 | 0.014 |
Brugia malayi | RNA binding protein | 0.0076 | 0.0548 | 0.0548 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.0548 | 0.0548 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.1095 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.0548 | 0.0548 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1095 | 1 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.1095 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0473 | 0.4232 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.1095 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.1095 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0548 | 0.0414 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.014 | 0.014 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.014 | 0.014 |
Echinococcus granulosus | glycogen phosphorylase | 0.1095 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0548 | 0.0414 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1095 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.0548 | 0.0548 |
Echinococcus granulosus | glycogen phosphorylase | 0.1095 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0473 | 0.4232 | 0.415 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0548 | 0.0414 |
Echinococcus multilocularis | glycogen phosphorylase | 0.1095 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.1095 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.1095 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0135 | 0.0135 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.0548 | 0.0414 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.0548 | 0.0548 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.004 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.