Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | chromobox homolog 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0051 | 0.0077 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0512 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0512 | 1 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0084 | 0.0795 | 0.0795 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0238 | 0.0238 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.0795 | 0.057 |
Loa Loa (eye worm) | hypothetical protein | 0.0512 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0795 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0084 | 0.0795 | 0.0795 |
Schistosoma mansoni | tyrosinase precursor | 0.0512 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.5126 | 0.5126 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0512 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.5126 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0084 | 0.0795 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0512 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0512 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0084 | 0.0795 | 0.057 |
Onchocerca volvulus | 0.0512 | 1 | 1 | |
Onchocerca volvulus | 0.0058 | 0.0238 | 0.0238 | |
Onchocerca volvulus | 0.0512 | 1 | 1 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0512 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.0512 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0077 | 0.0969 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.5126 | 0.5126 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0512 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0512 | 1 | 1 |
Onchocerca volvulus | 0.0512 | 1 | 1 | |
Onchocerca volvulus | 0.0512 | 1 | 1 | |
Loa Loa (eye worm) | tyrosinase 1 | 0.0512 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.5126 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0051 | 0.0077 | 0.0969 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1259 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 0.1585 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.