Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.2882 | 0.2882 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0957 | 0.5 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.018 | 0.4224 | 0.3965 |
Echinococcus granulosus | integrin beta 2 | 0.0273 | 0.7075 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0081 | 0.1184 | 0.0371 |
Schistosoma mansoni | integrin alpha-ps | 0.0081 | 0.1184 | 0.2209 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0957 | 0.1786 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0278 | 0.7208 | 0.7208 |
Loa Loa (eye worm) | integrin beta-2 | 0.0369 | 1 | 1 |
Schistosoma mansoni | integrin alpha | 0.018 | 0.4224 | 0.7881 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0957 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0429 | 0.0429 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0957 | 0.1786 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0957 | 0.5 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0056 | 0.0429 | 0.0429 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0136 | 0.2882 | 0.2563 |
Schistosoma mansoni | integrin beta subunit | 0.0217 | 0.536 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0081 | 0.1184 | 0.0371 |
Echinococcus multilocularis | integrin alpha ps | 0.0081 | 0.1184 | 0.0371 |
Echinococcus multilocularis | integrin beta 2 | 0.0273 | 0.7075 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0957 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1754 | 0.1754 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0957 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.304 | 0.304 |
Echinococcus multilocularis | integrin alpha 3 | 0.0138 | 0.2938 | 0.3237 |
Echinococcus granulosus | integrin alpha 3 | 0.0138 | 0.2938 | 0.3237 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0957 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1192 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.