Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0109 | 0.4211 | 0.4211 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1746 | 0.4147 |
Onchocerca volvulus | 0.0109 | 0.4211 | 0.4211 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0065 | 0.2216 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0109 | 0.4211 | 0.4211 |
Mycobacterium ulcerans | hypothetical protein | 0.0017 | 0 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0092 | 0.3425 | 0.8134 |
Echinococcus granulosus | Endonuclease G | 0.0065 | 0.2216 | 0.5262 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0065 | 0.2216 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0109 | 0.4211 | 0.4211 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.5823 | 0.5823 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1746 | 0.4147 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.061 | 0.2751 |
Trypanosoma brucei | endonuclease G, putative | 0.0065 | 0.2216 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1746 | 0.1746 |
Trypanosoma brucei | endonuclease G, putative | 0.0065 | 0.2216 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1206 | 0.2864 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.061 | 0.2751 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1206 | 1 |
Echinococcus granulosus | ectonucleotide | 0.0092 | 0.3425 | 0.8134 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1746 | 0.1746 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.061 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0092 | 0.3425 | 0.8134 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1746 | 0.1746 |
Schistosoma mansoni | endonuclease related | 0.0065 | 0.2216 | 0.2216 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1746 | 0.4147 |
Mycobacterium leprae | hypothetical protein | 0.0017 | 0 | 0.5 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0235 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1746 | 0.1746 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1746 | 0.4147 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1206 | 1 |
Giardia lamblia | Phosphatidylinositol-glycan biosynthesis, class O protein | 0.0017 | 0 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Brugia malayi | hypothetical protein | 0.002 | 0.0115 | 0.0115 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1206 | 0.1206 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.061 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.061 | 0.061 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.5823 | 0.5823 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1206 | 0.1206 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.5823 | 0.5823 |
Onchocerca volvulus | 0.0109 | 0.4211 | 0.4211 | |
Echinococcus multilocularis | ectonucleotide | 0.0092 | 0.3425 | 0.8134 |
Leishmania major | endonuclease G, putative | 0.0065 | 0.2216 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0065 | 0.2216 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0065 | 0.2216 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.061 | 0.061 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0109 | 0.4211 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.4211 | 0.4211 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.4211 | 0.4211 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0109 | 0.4211 | 1 |
Echinococcus multilocularis | Endonuclease G | 0.0065 | 0.2216 | 0.5262 |
Schistosoma mansoni | hypothetical protein | 0.0235 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1206 | 0.2864 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1746 | 0.1746 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1206 | 0.1206 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0.061 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.4211 | 0.4211 |
Onchocerca volvulus | 0.0235 | 1 | 1 | |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0109 | 0.4211 | 0.4211 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0065 | 0.2216 | 1 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.0065 | 0.2216 | 0.2216 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1206 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0065 | 0.2216 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0065 | 0.2216 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1206 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.3425 | 0.3425 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 58.2 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571] | ChEMBL. | No reference |
EC50 (functional) | = 66.1 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571] | ChEMBL. | No reference |
EC50 (functional) | = 68.7 uM | PUBCHEM_BIOASSAY: Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571] | ChEMBL. | No reference |
EC50 (functional) | 79.7 uM | PUBCHEM_BIOASSAY: Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571] | ChEMBL. | No reference |
EC50 (functional) | = 81.4 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571] | ChEMBL. | No reference |
Potency (functional) | 2.8184 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.9811 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.9185 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.