Detailed information for compound 1378673

Basic information

Technical information
  • TDR Targets ID: 1378673
  • Name: EU-0045734
  • MW: 422.54 | Formula: C24H26N2O3S
  • H donors: 0 H acceptors: 3 LogP: 4.38 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)CN(S(=O)(=O)c1ccccc1)c1cccc(c1C)C)Cc1ccccc1
  • InChi: 1S/C24H26N2O3S/c1-19-11-10-16-23(20(19)2)26(30(28,29)22-14-8-5-9-15-22)18-24(27)25(3)17-21-12-6-4-7-13-21/h4-16H,17-18H2,1-3H3
  • InChiKey: WROZNYYIPZQONJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ZINC01139697
  • NCGC00099700-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0744 0.7765
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0128 0.0095
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0011 0.0128 0.0112
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.1054 0.2359
Entamoeba histolytica hypothetical protein 0.0036 0.0756 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0325 0.0362
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0011 0.0128 0.0091
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.0128 0.1336
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0744 0.1774
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Brugia malayi hypothetical protein 0.0036 0.0756 0.0945
Trypanosoma cruzi ribonuclease H1, putative 0.0044 0.0959 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0091
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.0128 0.0112
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0756 0.1802
Schistosoma mansoni hypothetical protein 0.0019 0.0325 0.0753
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3062 0.7418
Mycobacterium ulcerans hypothetical protein 0.0035 0.0744 0.5
Trypanosoma brucei ribonuclease H1 0.0044 0.0959 0.2116
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0744 0.0925
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0011 0.0128 0.0112
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Loa Loa (eye worm) hypothetical protein 0.006 0.1389 0.1798
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0744 0.5
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Brugia malayi RNA binding protein 0.0125 0.3062 0.4065
Echinococcus granulosus muscleblind protein 0.0295 0.7448 0.7444
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Loa Loa (eye worm) hypothetical protein 0.0035 0.0744 0.0925
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0061 0.0045
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0091
Leishmania major ribonuclease H1, putative 0.0044 0.0959 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Loa Loa (eye worm) beta-lactamase 0.0035 0.0744 0.0925
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.0128 0.1336
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1229 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0091
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0744 0.5
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0128 0.0273
Schistosoma mansoni phosphoglucomutase 0.0044 0.0959 0.2295
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Trypanosoma cruzi ribonuclease H1, putative 0.0044 0.0959 1
Entamoeba histolytica hypothetical protein 0.0036 0.0756 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Entamoeba histolytica hypothetical protein 0.0036 0.0756 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1007 0.0992
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0128 0.0273
Toxoplasma gondii ABC1 family protein 0.0035 0.0744 0.5597
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0744 0.7421
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0011 0.0128 0.0112
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0744 0.7765
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0011 0.0128 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0744 0.0925
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0744 0.073
Schistosoma mansoni hypothetical protein 0.0019 0.0325 0.0753
Schistosoma mansoni hypothetical protein 0.0166 0.4123 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0128 0.0273
Brugia malayi CXXC zinc finger family protein 0.0029 0.057 0.0693
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.0128 0.0112
Onchocerca volvulus 0.0035 0.0744 0.4488
Trypanosoma brucei unspecified product 0.0047 0.1054 0.2359
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0128 0.0273
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0325 0.031
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.5
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0744 0.1774
Echinococcus granulosus ribonuclease H1 0.0044 0.0959 0.0944
Plasmodium falciparum phosphodiesterase delta, putative 0.0011 0.0128 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0744 0.7765
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0011 0.0128 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3062 0.7418
Loa Loa (eye worm) hypothetical protein 0.0035 0.0744 0.0925
Brugia malayi beta-lactamase 0.0035 0.0744 0.0929
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0128 0.1336
Plasmodium falciparum phosphodiesterase gamma, putative 0.0011 0.0128 0.5
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0325 0.0362
Trypanosoma brucei RNA helicase, putative 0.0163 0.4054 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0011 0.0128 0.0112
Onchocerca volvulus 0.0035 0.0744 0.4488
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1007 0.2413
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1389 0.1802
Leishmania major hypothetical protein, conserved 0.0035 0.0744 0.7421
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Loa Loa (eye worm) RNA binding protein 0.0125 0.3062 0.4063
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0744 0.0929
Schistosoma mansoni hypothetical protein 0.0163 0.4054 0.9834
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0744 0.7765
Echinococcus multilocularis GPCR, family 2 0.0019 0.0325 0.031
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0744 0.157
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0011 0.0128 0.0273
Echinococcus multilocularis geminin 0.0166 0.4123 0.4113
Mycobacterium ulcerans beta-lactamase 0.0035 0.0744 0.5
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0744 1
Giardia lamblia Ribonuclease H 0.0044 0.0959 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0011 0.0128 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0744 0.7421
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Entamoeba histolytica hypothetical protein 0.0036 0.0756 0.5
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0011 0.0128 0.0112
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0128 0.1336
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0011 0.0128 0.1336
Onchocerca volvulus Ribonuclease H1 homolog 0.0044 0.0959 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1007 0.128
Brugia malayi Muscleblind-like protein 0.0295 0.7448 1
Trypanosoma brucei ingi protein (ORF1) 0.0047 0.1054 0.2359
Loa Loa (eye worm) hypothetical protein 0.0035 0.0744 0.0925
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Brugia malayi RNase H family protein 0.0044 0.0959 0.1219
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0744 0.5
Brugia malayi RNase H family protein 0.0044 0.0959 0.1219
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0128 0.0095
Loa Loa (eye worm) hypothetical protein 0.0035 0.0744 0.0925
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0011 0.0128 0.0273
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1389 0.1802
Trypanosoma brucei ingi protein (ORF1) 0.0047 0.1054 0.2359
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.3062 0.4063
Mycobacterium leprae Probable lipase LipE 0.0035 0.0744 0.5
Loa Loa (eye worm) hypothetical protein 0.0295 0.7448 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1007 0.0992
Echinococcus multilocularis muscleblind protein 1 0.0295 0.7448 0.7444
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.5656 1
Echinococcus multilocularis muscleblind protein 0.0295 0.7448 0.7444
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0011 0.0128 0.0112
Brugia malayi RNase H family protein 0.0044 0.0959 0.1219
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Schistosoma mansoni cpg binding protein 0.003 0.0612 0.1451
Echinococcus granulosus cpg binding protein 0.003 0.0612 0.0597
Schistosoma mansoni hypothetical protein 0.0019 0.0325 0.0753
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0744 0.073
Echinococcus granulosus geminin 0.0166 0.4123 0.4113
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0011 0.0128 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3062 0.7418
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0011 0.0128 0.0273
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0011 0.0128 0.0095
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0011 0.0128 0.0095
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Schistosoma mansoni phosphoglucomutase 0.0044 0.0959 0.2295
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3062 0.7418
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis esterase, putative 0.0035 0.0744 0.7765
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0011 0.0128 0.5
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0325 0.031
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0011 0.0128 0.0112
Echinococcus multilocularis cpg binding protein 0.003 0.0612 0.0597
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0128 0.1336
Brugia malayi TAR-binding protein 0.0125 0.3062 0.4065
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0744 0.7765
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0011 0.0128 0.0112
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0325 0.031
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0044 0.0959 0.5
Onchocerca volvulus 0.0035 0.0744 0.4488
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Echinococcus granulosus GPCR family 2 0.0019 0.0325 0.031
Schistosoma mansoni hypothetical protein 0.0166 0.4123 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1389 0.1798
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0128 0.0273
Echinococcus multilocularis tar DNA binding protein 0.0125 0.3062 0.3051
Toxoplasma gondii ribonuclease HI protein 0.0044 0.0959 0.7543
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1007 0.2413
Schistosoma mansoni hypothetical protein 0.0041 0.0897 0.2145
Loa Loa (eye worm) TAR-binding protein 0.0125 0.3062 0.4063
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0011 0.0128 0.0112
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.3062 0.4065
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0011 0.0128 0.0273
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1007 0.1284
Treponema pallidum ribonuclease H (rnhA) 0.0044 0.0959 0.5
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0393 1 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0011 0.0128 0.0095
Loa Loa (eye worm) hypothetical protein 0.0041 0.0897 0.1132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1007 0.2413
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1007 0.0992
Loa Loa (eye worm) PDE1B protein 0.0011 0.0128 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3062 0.7418
Echinococcus granulosus tar DNA binding protein 0.0125 0.3062 0.3051
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Loa Loa (eye worm) hypothetical protein 0.0019 0.0325 0.0358
Schistosoma mansoni hypothetical protein 0.0019 0.0325 0.0753
Loa Loa (eye worm) hypothetical protein 0.0295 0.7448 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.5
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0011 0.0128 0.0273
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0325 0.0358
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0897 0.1135
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis ribonuclease H1, putative 0.0044 0.0959 1
Schistosoma mansoni phosphoglucomutase 0.0044 0.0959 0.2295
Echinococcus multilocularis ribonuclease H1 0.0044 0.0959 0.0944
Schistosoma mansoni hypothetical protein 0.0036 0.0756 0.1802
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0756 0.0741
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0011 0.0128 0.0095
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.057 0.0689
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0325 0.031
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0061 0.0045
Mycobacterium ulcerans lipase LipD 0.0035 0.0744 0.5
Schistosoma mansoni cpg binding protein 0.0029 0.057 0.1349
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0047 0.1054 0.2359
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Schistosoma mansoni cpg binding protein 0.003 0.0612 0.1451
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1396 0.3361
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0011 0.0128 0.0273
Brugia malayi beta-lactamase family protein 0.0035 0.0744 0.0929
Loa Loa (eye worm) hypothetical protein 0.0035 0.0744 0.0925
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1007 0.0992
Brugia malayi beta-lactamase family protein 0.0035 0.0744 0.0929
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0011 0.0128 0.1336
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0011 0.0128 0.1336
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0756 0.0741

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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