Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | CDC-like kinase 4 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | carbonic anhydrase family protein, putative | 0.0544 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0245 | 0.2729 | 0.2729 |
Schistosoma mansoni | carbonic anhydrase | 0.0544 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0245 | 0.2729 | 0.2729 |
Echinococcus granulosus | carbonic anhydrase II | 0.0245 | 0.2729 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0133 | 0 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0309 | 0.4282 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0235 | 0.2495 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0245 | 0.2729 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0245 | 0.2729 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0235 | 0.2495 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0245 | 0.2729 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0245 | 0.2729 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0245 | 0.2729 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0245 | 0.2729 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0544 | 1 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0133 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0245 | 0.2729 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0245 | 0.2729 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0544 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.6267 uM | PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1379, AID1770, AID1983, AID1997, AID2710, AID488872, AID488883, AID488887, AID493206, AID504421, AID504424, AID504427, AID504428, AID504429, AID504430] | ChEMBL. | No reference |
Potency (functional) | 23.1882 uM | PUBCHEM_BIOASSAY: Assay for Inhibitors of Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A (Kinase-Glo assay). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1770, AID1997, AID488872, AID488883, AID488887, AID493206] | ChEMBL. | No reference |
Potency (functional) | 33.8078 uM | PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency_Clk4_uM (functional) | 9.957 uM | PUBCHEM_BIOASSAY: Kinase Inhibition Study on Inhibitors of CDC-like Kinase 4 (Reaction Biology data): SAR round 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1459, AID1487, AID1498, AID1770, AID1970, AID1997, AID488872, AID488883, AID488887, AID493204] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.