Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Homo sapiens | multiple endocrine neoplasia I | No references | |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0455 | 0.4736 | 0.5357 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.084 | 0.879 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0455 | 0.4736 | 0.5357 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0038 | 0.0038 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0405 | 0.0419 |
Onchocerca volvulus | 0.0035 | 0.0313 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase-related | 0.0455 | 0.4736 | 0.4736 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.5147 | 0.5147 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0334 | 0.0334 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.084 | 0.879 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0455 | 0.4736 | 0.5356 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.4736 | 0.5356 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.084 | 0.879 | 0.5 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0334 | 0.0337 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0413 | 0.4295 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.084 | 0.879 | 0.879 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.4736 | 0.5356 |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.5147 | 0.5838 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0313 | 0.0289 |
Echinococcus granulosus | carbonic anhydrase | 0.0455 | 0.4736 | 0.5368 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0455 | 0.4736 | 0.4736 |
Echinococcus multilocularis | carbonic anhydrase | 0.0455 | 0.4736 | 0.5368 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0405 | 0.0405 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0061 | 0.0025 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0061 | 0.0025 |
Toxoplasma gondii | hypothetical protein | 0.0455 | 0.4736 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0955 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0455 | 0.4736 | 0.4736 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0334 | 0.0334 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0455 | 0.4736 | 0.5357 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.4736 | 0.5356 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0955 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0455 | 0.4736 | 0.4736 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.0722 | 0.0722 |
Echinococcus granulosus | carbonic anhydrase | 0.0455 | 0.4736 | 0.5368 |
Echinococcus granulosus | carbonic anhydrase | 0.0455 | 0.4736 | 0.5368 |
Echinococcus multilocularis | carbonic anhydrase | 0.0455 | 0.4736 | 0.5368 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0413 | 0.4295 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0455 | 0.4736 | 0.5357 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0405 | 0.0396 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.084 | 0.879 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0455 | 0.4736 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.084 | 0.879 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0405 | 0.0405 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.5147 | 0.5838 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0455 | 0.4736 | 0.5357 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0405 | 0.0419 |
Echinococcus granulosus | carbonic anhydrase II | 0.084 | 0.879 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.084 | 0.879 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0334 | 0.0337 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.084 | 0.879 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0542 | 0.5653 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0455 | 0.4736 | 0.4736 |
Echinococcus multilocularis | carbonic anhydrase | 0.0455 | 0.4736 | 0.5368 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0313 | 0.0313 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0955 | 1 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0313 | 0.029 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.084 | 0.879 | 0.879 |
Schistosoma mansoni | carbonic anhydrase | 0.0955 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.084 | 0.879 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 21.3313 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 75.6863 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.