Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Trypanosoma brucei | phosphoglycerate kinase | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Trypanosoma brucei gambiense | phosphoglycerate kinase, putative | No references | |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable phosphoglycerate kinase Pgk | 0.0206 | 0.1872 | 1 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0206 | 0.1872 | 0.5 |
Toxoplasma gondii | phosphoglycerate kinase PGKII | 0.0206 | 0.1872 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0204 | 0.1854 | 0.3657 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0206 | 0.1872 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.1228 | 0.5283 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1608 | 0.2223 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1872 | 0.3766 |
Wolbachia endosymbiont of Brugia malayi | phosphoglycerate kinase | 0.0206 | 0.1872 | 0.5 |
Echinococcus multilocularis | phosphoglycerate kinase 1 | 0.0206 | 0.1872 | 0.0315 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.1608 | 0.8068 |
Plasmodium vivax | phosphoglycerate kinase, putative | 0.0206 | 0.1872 | 0.5 |
Entamoeba histolytica | phosphoglycerate kinase, putative | 0.0206 | 0.1872 | 0.5 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0206 | 0.1872 | 1 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0206 | 0.1872 | 1 |
Toxoplasma gondii | phosphoglycerate kinase PGKI | 0.0206 | 0.1872 | 0.5 |
Schistosoma mansoni | phosphoglycerate kinase | 0.0206 | 0.1872 | 1 |
Trichomonas vaginalis | phosphoglycerate kinase, putative | 0.0206 | 0.1872 | 0.5 |
Mycobacterium ulcerans | phosphoglycerate kinase | 0.0206 | 0.1872 | 1 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.03 | 0.2862 | 0.1494 |
Giardia lamblia | Phosphoglycerate kinase | 0.0206 | 0.1872 | 0.5 |
Plasmodium falciparum | phosphoglycerate kinase | 0.0206 | 0.1872 | 0.5 |
Treponema pallidum | phosphoglycerate kinase | 0.0206 | 0.1872 | 0.5 |
Mycobacterium leprae | Probable phosphoglycerate kinase Pgk | 0.0206 | 0.1872 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.2653 | 0.8325 |
Leishmania major | phosphoglycerate kinase B, cytosolic | 0.0206 | 0.1872 | 1 |
Brugia malayi | Phosphoglycerate kinase | 0.0206 | 0.1872 | 1 |
Leishmania major | phosphoglycerate kinase C, glycosomal | 0.0206 | 0.1872 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0307 | 0.2939 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1608 | 0.2223 |
Chlamydia trachomatis | phosphoglycerate kinase | 0.0206 | 0.1872 | 0.5 |
Trypanosoma cruzi | phosphoglycerate kinase, putative | 0.0206 | 0.1872 | 1 |
Trypanosoma brucei | phosphoglycerate kinase | 0.0206 | 0.1872 | 1 |
Echinococcus granulosus | phosphoglycerate kinase 1 | 0.0206 | 0.1872 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 15.8489 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 16.3535 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (binding) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.