TDR Targets

Basic information

Technical information

TDR Targets ID: 1389504
Name: [2-[2-(1-cyclohexenyl)ethylamino]-2-oxoethyl] (E)-3-(3-chlorophenyl)prop-2-enoate
MW: 347.836 | Formula: C19H22ClNO3
H donors: 1 H acceptors: 2 LogP: 4.22 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=C(COC(=O)/C=C/c1cccc(c1)Cl)NCCC1=CCCCC1
InChi: 1S/C19H22ClNO3/c20-17-8-4-7-16(13-17)9-10-19(23)24-14-18(22)21-12-11-15-5-2-1-3-6-15/h4-5,7-10,13H,1-3,6,11-12,14H2,(H,21,22)/b10-9+
InChiKey: IKSKUGNHAHVCDT-MDZDMXLPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[2-[2-(1-cyclohexenyl)ethylamino]-2-oxoethyl] 3-(3-chlorophenyl)prop-2-enoate
[2-[2-(1-cyclohexenyl)ethylamino]-2-oxo-ethyl] 3-(3-chlorophenyl)prop-2-enoate
[2-[2-(1-cyclohexenyl)ethylamino]-2-oxo-ethyl] (E)-3-(3-chlorophenyl)prop-2-enoate
3-(3-chlorophenyl)prop-2-enoic acid [2-[2-(1-cyclohexenyl)ethylamino]-2-oxoethyl] ester
(E)-3-(3-chlorophenyl)prop-2-enoic acid [2-[2-(1-cyclohexenyl)ethylamino]-2-oxoethyl] ester
(E)-3-(3-chlorophenyl)acrylic acid [2-[2-(1-cyclohexenyl)ethylamino]-2-keto-ethyl] ester
3-(3-chlorophenyl)acrylic acid [2-[2-(1-cyclohexenyl)ethylamino]-2-keto-ethyl] ester
ZINC03278568
MLS000392539
SMR000261480
T0514-5896

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chromobox homolog 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Theileria parva	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Brugia malayi	Heterochromatin protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma japonicum	Chromobox protein homolog 5, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus	Heterochromatin protein 1 homolog	Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Schistosoma mansoni	chromobox protein	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus granulosus	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545
Onchocerca volvulus		Get druggable targets OG5_129545	All targets in OG5_129545
Trichomonas vaginalis	chromobox protein, putative	Get druggable targets OG5_129545	All targets in OG5_129545
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129545	All targets in OG5_129545
Echinococcus multilocularis	chromobox protein 1	Get druggable targets OG5_129545	All targets in OG5_129545

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0454	0.8107
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Entamoeba histolytica	hypothetical protein	0.0024	0.0243	0.5309
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0776	0.3645
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0042	0.013
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0042	0.013
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0042	0.0028
Leishmania major	glucose transporter, lmgt3	0.0033	0.0454	0.8107
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0445	0.043
Onchocerca volvulus	Putative transporter	0.0015	0.0042	0.0327
Echinococcus granulosus	solute carrier family 22	0.0015	0.0042	0.013
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0243	0.3046
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0243	0.1079
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0042	0.013
Onchocerca volvulus		0.0015	0.0042	0.0327
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0042	0.0042
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0462	0.2115
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0444	0.2032
Schistosoma mansoni	glucose transport protein	0.0107	0.2128	1
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0243	0.0228
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0444	0.2032
Onchocerca volvulus		0.0015	0.0042	0.0327
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0454	0.8107
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0444	0.7919
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0429	0.1961
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0243	0.5
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0243	0.1079
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Brugia malayi	major facilitator superfamily protein	0.0015	0.0042	0.013
Brugia malayi	Cam kinase protein 1	0.0033	0.0444	0.2032
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0454	0.8107
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0015	0.007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0398	0.1815
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Onchocerca volvulus		0.0015	0.0042	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.055	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0462	0.2115
Schistosoma mansoni	sugar transporter	0.0015	0.0042	0.013
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0243	0.395
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0243	0.0348
Brugia malayi	chromobox protein homolog 3	0.0047	0.0776	0.36
Brugia malayi	Sugar transporter family protein	0.0107	0.2128	1
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.055	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0543	0.2554
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0454	0.8107
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0042	0.013
Loa Loa (eye worm)	sugar transporter	0.0015	0.0042	0.0199
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0042	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0776	0.36
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0429	0.965
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.007
Leishmania major	protein kinase, putative	0.0033	0.0444	0.7919
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0454	0.2077
Echinococcus granulosus	solute carrier family 22	0.0015	0.0042	0.013
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0444	0.2032
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0429	0.1961
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0042	0.013
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0429	0.2017
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Brugia malayi	Sugar transporter family protein	0.0015	0.0042	0.013
Echinococcus multilocularis	chromobox protein 1	0.0084	0.1618	0.7586
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0445	0.043
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0454	0.8107
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0445	0.0657
Trypanosoma cruzi	hexose transporter	0.0033	0.0454	0.8107
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0445	0.043
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0445	0.043
Echinococcus multilocularis	chromobox protein 1	0.0084	0.1618	0.7586
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0454	0.2077
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Brugia malayi	Heterochromatin protein 1	0.0084	0.1618	0.7586
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0243	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Schistosoma mansoni	hypothetical protein	0.0107	0.2128	1
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0454	0.2077
Entamoeba histolytica	protein kinase, putative	0.0033	0.0444	1
Schistosoma mansoni	protein kinase	0.0033	0.0444	0.2032
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2128	1
Loa Loa (eye worm)	sugar transporter	0.0107	0.2128	1
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0445	0.043
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.055	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0454	0.8107
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0429	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0042	0.013
Loa Loa (eye worm)	helicase	0.0014	0.0015	0.007
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0042	0.013
Onchocerca volvulus		0.0015	0.0042	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.055	0.0536
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2128	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0445	0.043
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0454	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2128	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.0444	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0444	0.2032
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0176	0.0763
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Plasmodium vivax	sugar transporter, putative	0.0015	0.0042	0.0028
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0113	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0429	0.2017
Plasmodium vivax	hexose transporter	0.0107	0.2128	0.2116
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0243	0.1079
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0454	0.8107
Brugia malayi	major facilitator superfamily protein	0.0015	0.0042	0.013
Onchocerca volvulus		0.0015	0.0042	0.0327
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0398	0.1815
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0454	0.8107
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0454	0.8107
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Onchocerca volvulus		0.0015	0.0042	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0454	0.8107
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0445	0.043
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2128	1
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0042	0.013
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Schistosoma mansoni	chromobox protein	0.0084	0.1618	0.7586
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0243	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.007
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0042	0.013
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2128	1
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.2128	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0776	0.9031
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0454	0.8107
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0857	0.3986
Onchocerca volvulus		0.0015	0.0042	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0042	0.013
Schistosoma mansoni	sugar transporter	0.0015	0.0042	0.013
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.055	0.0536
Toxoplasma gondii	protein kinase, putative	0.0301	0.6557	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2128	1
Onchocerca volvulus		0.0037	0.0543	0.6276
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0444	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0243	0.1141
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0042	0.0042
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0042	0.0199
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0454	0.8107
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0454	0.8107
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0243	0.5182
Onchocerca volvulus		0.0015	0.0042	0.0327
Onchocerca volvulus		0.0015	0.0042	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.055	0.0818
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.055	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Onchocerca volvulus		0.0015	0.0042	0.0327
Brugia malayi	hypothetical protein	0.0015	0.0042	0.013
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0429	0.1961
Schistosoma mansoni	protein kinase	0.0033	0.0444	0.2032
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0454	0.8107
Leishmania major	glucose transporter, lmgt1	0.0033	0.0454	0.8107
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0042	0.013
Schistosoma mansoni	protein kinase	0.0033	0.0444	0.2032
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0444	0.2032
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0444	0.2032
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0445	0.0657
Echinococcus granulosus	chromobox protein 1	0.0084	0.1618	0.7586
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0243	0.1079
Echinococcus granulosus	chromobox protein 1	0.0084	0.1618	0.7586
Schistosoma mansoni	glucose transporter	0.0015	0.0042	0.013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0445	0.0657
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0042	0.013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0454	0.2077
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.007
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0243	0.1079
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0042	0.5
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0172	0.3622	0.3613
Onchocerca volvulus		0.0015	0.0042	0.0327
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0042	0.0199
Echinococcus granulosus	solute carrier family 22	0.0015	0.0042	0.013
Schistosoma mansoni	sugar transporter	0.0015	0.0042	0.013
Brugia malayi	hypothetical protein	0.0015	0.0042	0.013
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0107	0.2128	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0454	0.2077
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0454	0.8107
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0444	0.2088
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0444	0.2032
Echinococcus granulosus	General substrate transporter	0.0092	0.1787	0.8385
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0454	0.2077
Echinococcus granulosus	solute carrier family 22	0.0015	0.0042	0.013
Brugia malayi	Sugar transporter family protein	0.0015	0.0042	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0042	0.013
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.1618	0.7586
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0452	1	1
Onchocerca volvulus		0.0015	0.0042	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Schistosoma mansoni	glucose transport protein	0.0107	0.2128	1
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0042	0.0042
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0429	0.1961
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0445	0.043
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0042	0.013
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0042	0.013
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0042	0.013
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2128	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0454	0.8107
Loa Loa (eye worm)	heterochromatin protein 1	0.0084	0.1618	0.7603
Trichomonas vaginalis	chromobox protein, putative	0.0051	0.0857	0.3986
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0293	0.1375
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0429	0.1961
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0429	0.1961
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0444	0.2032
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Schistosoma mansoni	chromobox protein	0.0084	0.1618	0.7586
Onchocerca volvulus		0.0015	0.0042	0.0327
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0172	0.3622	0.3613
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0042	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0776	0.36
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.055	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0444	0.2032
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0243	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0454	0.2077
Onchocerca volvulus		0.0015	0.0042	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.007
Brugia malayi	hypothetical protein	0.0015	0.0042	0.013
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0444	0.2088
Schistosoma mansoni	glucose transport protein	0.0107	0.2128	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0243	0.1079
Plasmodium falciparum	protein kinase 7	0.0301	0.6557	0.6552
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0444	0.2032
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0051	0.0857	1
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0243	0.395
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0042	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.007
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0444	0.2032
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0243	0.395
Schistosoma mansoni	sugar transporter	0.0015	0.0042	0.013
Plasmodium falciparum	hexose transporter	0.0107	0.2128	0.2116
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0042	0.013
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0429	1
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0161	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0042	0.013
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0429	0.1961
Onchocerca volvulus		0.0015	0.0042	0.0327
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0161	1
Echinococcus multilocularis	General substrate transporter	0.0092	0.1787	0.8385
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0042	0.013
Toxoplasma gondii	facilitative glucose transporter GT1	0.0107	0.2128	0.323
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0172	0.3622	0.5514
Trichomonas vaginalis	chromobox protein, putative	0.0084	0.1618	0.7586
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0445	0.043
Leishmania major	glucose transporter, lmgt2	0.0033	0.0454	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0015	0.007
Onchocerca volvulus		0.0015	0.0042	0.0327

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.5849 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	37.933 uM	PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1525023

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1389504