Detailed information for compound 1389995

Basic information

Technical information
  • TDR Targets ID: 1389995
  • Name: 3-imidazo[1,2-a]pyrimidin-2-ylaniline
  • MW: 210.235 | Formula: C12H10N4
  • H donors: 1 H acceptors: 2 LogP: 2.09 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1cccc(c1)c1cn2c(n1)nccc2
  • InChi: 1S/C12H10N4/c13-10-4-1-3-9(7-10)11-8-16-6-2-5-14-12(16)15-11/h1-8H,13H2
  • InChiKey: HUUWWGMUBHRQMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(2-imidazo[1,2-a]pyrimidinyl)aniline
  • (3-imidazo[1,2-a]pyrimidin-2-ylphenyl)amine
  • MLS000719192
  • SMR000291460
  • ZERO/008443
  • Oprea1_669493
  • 3-Imidazo[1,2-a]pyrimidin-2-yl-phenylamine
  • ASN 15366292

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens growth factor, augmenter of liver regeneration Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium knowlesi FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Brugia malayi Augmenter of liver regeneration Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Theileria parva hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis human hepatopoietin-like protein, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hepatopoietin HPO2 Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Toxoplasma gondii Erv1 / Alr family protein Get druggable targets OG5_127535 All targets in OG5_127535
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127535 All targets in OG5_127535
Candida albicans similar to S. cerevisiae ERV2 (YPR037C) endoplasmic reticulum flavin-linked sulfhydryl oxidase Get druggable targets OG5_127535 All targets in OG5_127535
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei FAD-linked sulfhydryl oxidase ERV1, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_127535 All targets in OG5_127535
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR Get druggable targets OG5_127535 All targets in OG5_127535
Schistosoma japonicum FAD-linked sulfhydryl oxidase ALR, putative Get druggable targets OG5_127535 All targets in OG5_127535
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.1524 0.1613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.1524 0.1613
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.4375 0.4628
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.9452 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.1524 0.1524
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.1524 1
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.9452 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.1524 0.1524
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.4375 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.1524 0.1524
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.1524 0.1613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.1524 0.1613
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.4375 0.4628
Onchocerca volvulus 0.0012 0.1524 1
Loa Loa (eye worm) hepatopoietin HPO2 0.0041 0.9452 1
Schistosoma mansoni nuclear hormone receptor 0.0012 0.1524 0.1524
Schistosoma mansoni ap endonuclease 0.0023 0.4375 0.4375
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.1524 0.1524
Schistosoma mansoni thyroid hormone receptor 0.0012 0.1524 0.1524
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.4375 0.5
Schistosoma mansoni hypothetical protein 0.0043 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.1524 0.1524
Loa Loa (eye worm) hypothetical protein 0.0012 0.1524 0.1613
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.1524 0.1613
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.1524 0.1524
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.1524 0.1524
Loa Loa (eye worm) hypothetical protein 0.0012 0.1524 0.1613
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.1524 0.1524
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0041 0.9452 0.9452
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.1524 0.1524
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0041 0.9452 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.4375 0.4628
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.1524 0.1524
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.1524 0.1524
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.1524 0.1524
Loa Loa (eye worm) hypothetical protein 0.0012 0.1524 0.1613
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.4375 0.4375
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.4375 0.5
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.1524 0.1524
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.1524 0.1524
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.1524 0.1524
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.1524 0.1524
Brugia malayi Augmenter of liver regeneration 0.0041 0.9452 0.9452
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.1524 0.1524
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.4375 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.1524 0.1524
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.1524 0.1524
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.1524 0.1524
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.1524 0.1524
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.1524 0.1524
Loa Loa (eye worm) hypothetical protein 0.0012 0.1524 0.1613
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.1524 0.1524
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.1524 0.1524
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.4375 0.4628
Loa Loa (eye worm) hypothetical protein 0.0012 0.1524 0.1613
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.4375 0.4628
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.1524 0.1524
Loa Loa (eye worm) hypothetical protein 0.0012 0.1524 0.1613
Entamoeba histolytica hypothetical protein 0.0043 1 1
Brugia malayi nuclear receptor NHR-88 0.0012 0.1524 0.1524
Entamoeba histolytica hypothetical protein 0.0043 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.4375 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.1524 0.1524
Toxoplasma gondii exonuclease III APE 0.0023 0.4375 0.4628
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.1524 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.1524 0.1524
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.1524 0.1524
Brugia malayi ecdysteroid receptor 0.0012 0.1524 0.1524
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.1524 0.1613
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.4375 0.5
Brugia malayi nuclear hormone receptor 0.0012 0.1524 0.1524
Brugia malayi steroid hormone receptor 0.0012 0.1524 0.1524
Entamoeba histolytica hypothetical protein 0.0043 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.1524 0.1524
Entamoeba histolytica hypothetical protein 0.0043 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.1524 0.1524
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 1 1
Leishmania major hypothetical protein, conserved 0.0041 0.9452 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.1524 0.1524
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.4375 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.1524 1
Toxoplasma gondii Erv1 / Alr family protein 0.0041 0.9452 1
Schistosoma mansoni coup transcription factor 0.0012 0.1524 0.1524
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.9452 1
Echinococcus granulosus FTZ F1 alpha 0.0012 0.1524 0.1524
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.1524 0.1613
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.1524 0.1524
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.9452 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.1524 0.1524
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.1524 0.1524
Schistosoma mansoni ap endonuclease 0.0023 0.4375 0.4375
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.1524 0.1524
Loa Loa (eye worm) hypothetical protein 0.0012 0.1524 0.1613
Loa Loa (eye worm) hypothetical protein 0.0012 0.1524 0.1613
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.4375 0.4375
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.1524 0.1524
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.1524 0.1524
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.1524 0.1613
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.1524 0.1524
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.1524 0.1524
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.1524 0.1524
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0041 0.9452 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.4375 0.4628
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.1524 0.1524
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0041 0.9452 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.1524 0.1524
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.1524 0.1524
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.4375 0.4375
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0041 0.9452 0.9452

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) = 0.232 uM PUBCHEM_BIOASSAY: HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488787] ChEMBL. No reference
Potency (functional) 0.005 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.8199 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.