Detailed information for compound 1395204

Basic information

Technical information
  • TDR Targets ID: 1395204
  • Name: N-(6-phenylimidazo[2,3-b][1,3]thiazol-5-yl)be nzamide
  • MW: 319.38 | Formula: C18H13N3OS
  • H donors: 1 H acceptors: 2 LogP: 4.69 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)Nc1c(nc2n1ccs2)c1ccccc1
  • InChi: 1S/C18H13N3OS/c22-17(14-9-5-2-6-10-14)20-16-15(13-7-3-1-4-8-13)19-18-21(16)11-12-23-18/h1-12H,(H,20,22)
  • InChiKey: MCSIZAMXJUWZDC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(6-phenylimidazo[2,3-b]thiazol-5-yl)benzamide
  • N-(6-phenyl-5-imidazo[2,3-b]thiazolyl)benzamide
  • MLS000105095
  • STOCK1S-27629
  • Oprea1_017313
  • ZINC00283788
  • Oprea1_658440
  • SMR000055024

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0462 0.0462
Trichomonas vaginalis CMGC family protein kinase 0.0716 0.9674 1
Echinococcus granulosus protein kinase shaggy 0.0215 0.2821 0.2821
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0215 0.2821 0.2916
Mycobacterium ulcerans transmembrane serine/threonine-protein kinase PknQ 0.0009 0 0.5
Trypanosoma brucei STE group serine/threonine-protein kinase, putative 0.0013 0.0054 0.0055
Mycobacterium tuberculosis Anchored-membrane serine/threonine-protein kinase PknF (protein kinase F) (STPK F) 0.0009 0 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0048 0.0048
Mycobacterium ulcerans anchored-membrane serine/threonine-protein kinase PknF 0.0009 0 0.5
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0048 0.0048
Mycobacterium tuberculosis Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) (STPK H) 0.0009 0 0.5
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0077 0.0077
Echinococcus granulosus cGMP dependent protein kinase 0.0015 0.0077 0.0077
Chlamydia trachomatis serine/threonine protein kinase 0.0009 0 0.5
Plasmodium vivax glycogen synthase kinase 3, putative 0.0215 0.2821 0.2916
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0077 0.0077
Mycobacterium leprae PROBABLE TRANSMEMBRANE SERINE/THREONINE-PROTEIN KINASE L PKNL (PROTEIN KINASE L) (STPK L) 0.0009 0 0.5
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0048 0.0048
Mycobacterium tuberculosis Probable transmembrane serine/threonine-protein kinase E PknE (protein kinase E) (STPK E) 0.0009 0 0.5
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0716 0.9674 1
Giardia lamblia Kinase, CMGC GSK 0.0215 0.2821 0.2916
Mycobacterium tuberculosis Serine/threonine-protein kinase transcriptional regulatory protein PknK (protein kinase K) (STPK K) 0.0009 0 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0048 0.0048
Trichomonas vaginalis CMGC family protein kinase 0.0716 0.9674 1
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.2821 0.2916
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0215 0.2821 0.2821
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0077 0.0077
Echinococcus multilocularis casein kinase ii subunit alpha 0.0716 0.9674 0.9674
Brugia malayi intracellular kinase 0.0215 0.2821 0.2821
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0423 0.0438
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0015 0.0077 0.0077
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0215 0.2821 0.2916
Mycobacterium ulcerans Ser/Thr protein kinase 0.0009 0 0.5
Echinococcus granulosus calcium activated potassium channel 0.0012 0.0038 0.0038
Mycobacterium ulcerans membrane-anchored serine/threonine-protein kinase 0.0009 0 0.5
Echinococcus multilocularis expressed conserved protein 0.0015 0.0077 0.0077
Chlamydia trachomatis serine/threonine protein kinase 0.0009 0 0.5
Entamoeba histolytica protein kinase, putative 0.0215 0.2821 0.2821
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0215 0.2821 0.2821
Trichomonas vaginalis CMGC family protein kinase 0.0716 0.9674 1
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0009 0 0.5
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0462 0.0462
Plasmodium falciparum glycogen synthase kinase 3 0.0215 0.2821 0.2916
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0077 0.0077
Giardia lamblia Kinase, CMGC GSK 0.0215 0.2821 0.2916
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0015 0.0077 0.008
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0009 0 0.5
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0716 0.9674 0.9674
Leishmania major protein kinase, putative 0.0015 0.0077 0.008
Trichomonas vaginalis CMGC family protein kinase 0.0716 0.9674 1
Schistosoma mansoni protein kinase 0.0716 0.9674 0.9674
Mycobacterium ulcerans serine/threonine-protein kinase PknG 0.0009 0 0.5
Leishmania major casein kinase II, putative 0.0716 0.9674 1
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A) 0.0009 0 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0716 0.9674 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0462 0.0462
Entamoeba histolytica protein kinase domain containing protein 0.0716 0.9674 0.9674
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0515 0.0515
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0215 0.2821 0.2821
Loa Loa (eye worm) hypothetical protein 0.0037 0.0385 0.0385
Plasmodium falciparum casein kinase 2, alpha subunit 0.0716 0.9674 1
Trypanosoma brucei protein kinase, putative 0.0215 0.2821 0.2916
Mycobacterium ulcerans serine/threonine-protein kinase a PknA 0.0009 0 0.5
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0215 0.2821 0.2821
Mycobacterium tuberculosis Probable transmembrane serine/threonine-protein kinase I PknI (protein kinase I) (STPK I) (phosphorylase B kinase kinase) (hydro 0.0009 0 0.5
Brugia malayi Casein kinase II, alpha chain 0.0716 0.9674 0.9674
Trichomonas vaginalis CMGC family protein kinase 0.0716 0.9674 1
Mycobacterium ulcerans Ser/Thr protein kinase 0.0009 0 0.5
Chlamydia trachomatis serine/threonine-protein kinase 0.0009 0 0.5
Echinococcus granulosus homeodomain interacting protein kinase 3 0.074 1 1
Entamoeba histolytica casein kinase, putative 0.0716 0.9674 0.9674
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.074 1 1
Entamoeba histolytica protein kinase domain containing protein 0.074 1 1
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0048 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.074 1 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0048 0.0048
Plasmodium falciparum cGMP-dependent protein kinase 0.0015 0.0077 0.008
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.074 1 1
Trypanosoma brucei Casein kinase II 0.0716 0.9674 1
Trichomonas vaginalis CMGC family protein kinase 0.0716 0.9674 1
Giardia lamblia Kinase, CMGC CK2 0.0716 0.9674 1
Trypanosoma cruzi casein kinase II, putative 0.0716 0.9674 1
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0215 0.2821 0.2916
Leishmania major protein kinase, putative 0.0015 0.0077 0.008
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0462 0.0462
Echinococcus multilocularis protein kinase shaggy 0.0215 0.2821 0.2821
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0048 0.0048
Mycobacterium tuberculosis Serine/threonine-protein kinase PknG (protein kinase G) (STPK G) 0.0009 0 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0215 0.2821 0.2821
Toxoplasma gondii CMGC kinase, CK2 family 0.0716 0.9674 1
Mycobacterium ulcerans Ser/Thr protein kinase 0.0009 0 0.5
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.004 0.0423 0.0438
Entamoeba histolytica protein kinase domain containing protein 0.0215 0.2821 0.2821
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0048 0.0048
Mycobacterium ulcerans serine/threonine-protein kinase transcriptional regulatory protein PknK_3 0.0009 0 0.5
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A) 0.0009 0 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0077 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0215 0.2821 0.2916
Mycobacterium ulcerans serine/threonine-protein kinase PknF_2 0.0009 0 0.5
Echinococcus multilocularis calcium activated potassium channel 0.0012 0.0038 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.0515 0.0515
Echinococcus granulosus casein kinase ii subunit alpha 0.0716 0.9674 0.9674
Mycobacterium ulcerans serine/threonine-protein kinase transcriptional regulatory protein PknK_2 0.0009 0 0.5
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0215 0.2821 0.2821
Loa Loa (eye worm) AGC/PKG protein kinase 0.0015 0.0077 0.0077
Echinococcus granulosus cGMP dependent protein kinase 1 0.0015 0.0077 0.0077
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0009 0 0.5
Mycobacterium ulcerans Ser/Thr protein kinase 0.0009 0 0.5
Onchocerca volvulus 0.0215 0.2821 1
Brugia malayi Egg laying defective protein 4 0.0015 0.0077 0.0077
Plasmodium vivax unspecified product 0.0716 0.9674 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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