TDR Targets

Basic information

Technical information

TDR Targets ID: 1399503
Name: N-(4-ethoxyphenyl)-3-[4-(4-fluorophenyl)sulfo nylpiperazin-1-yl]propanamide
MW: 435.512 | Formula: C21H26FN3O4S
H donors: 1 H acceptors: 3 LogP: 2.13 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)NC(=O)CCN1CCN(CC1)S(=O)(=O)c1ccc(cc1)F
InChi: 1S/C21H26FN3O4S/c1-2-29-19-7-5-18(6-8-19)23-21(26)11-12-24-13-15-25(16-14-24)30(27,28)20-9-3-17(22)4-10-20/h3-10H,2,11-16H2,1H3,(H,23,26)
InChiKey: VDOPUJDCRQXFBT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-ethoxyphenyl)-3-[4-(4-fluorophenyl)sulfonyl-1-piperazinyl]propanamide
N-(4-ethoxyphenyl)-3-[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]propionamide
EU-0032971

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.004	0.0079	0.0079
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.002	0.2526
Loa Loa (eye worm)	voltage-gated potassium channel	0.004	0.0079	0.008
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.002	0.2526
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0054	0.0054
Brugia malayi	ion channel NompC	0.004	0.0079	0.0079
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.002	1
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.004	0.0079	0.0079
Schistosoma mansoni	two-pore calcium channel	0.004	0.0079	0.0079
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.004	0.0079	0.0079
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0054	0.0054
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0079	0.0079
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.004	0.0079	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.0079	0.0079
Echinococcus multilocularis	calcium activated potassium channel	0.004	0.0079	0.0079
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0079	0.0738
Loa Loa (eye worm)	potassium voltage-gated channel subfamily Q member 5	0.1071	0.4449	0.4526
Onchocerca volvulus		0.0273	0.1064	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.002	0.2526
Loa Loa (eye worm)	hypothetical protein	0.1071	0.4449	0.4526
Echinococcus granulosus	two pore calcium channel protein 1	0.004	0.0079	0.0079
Plasmodium vivax	SET domain protein, putative	0.0034	0.0054	1
Trichomonas vaginalis	set domain proteins, putative	0.0273	0.1064	1
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0079	0.0079
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.0054	0.6863
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.004	0.0079	0.0079
Brugia malayi	hypothetical protein	0.004	0.0079	0.0079
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.031	0.031
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.004	0.0079	0.0079
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.1071	0.4449	0.4449
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Schistosoma mansoni	voltage-gated cation channel	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Schistosoma mansoni	voltage-gated ion channel	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Loa Loa (eye worm)	hypothetical protein	0.1071	0.4449	0.4526
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.0152	0.0152
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Schistosoma mansoni	voltage-dependent calcium channel	0.004	0.0079	0.0079
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.004	0.0079	0.0079
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.0079	0.0079
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0079	0.0079
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.0054	0.0054
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.004	0.0079	0.0079
Brugia malayi	hypothetical protein	0.0026	0.002	0.002
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.004	0.0079	0.008
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus granulosus	potassium voltage gated channel subfamily KQT	0.1071	0.4449	0.4449
Toxoplasma gondii	transporter, cation channel family protein	0.004	0.0079	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.0054	0.0054
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0079	0.0079
Echinococcus granulosus	potassium large conductance calcium activated	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus granulosus	short transient receptor potential channel 6	0.004	0.0079	0.0079
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.004	0.0079	0.0079
Echinococcus granulosus	sodium channel protein	0.004	0.0079	0.0079
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.004	0.0079	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0095	0.031	0.0316
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Schistosoma mansoni	vesicular amine transporter	0.004	0.0079	0.0079
Echinococcus granulosus	transient receptor potential gamma protein	0.004	0.0079	0.0079
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.004	0.0079	1
Echinococcus granulosus	voltage dependent calcium channel	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0152	0.0154
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Onchocerca volvulus		0.004	0.0079	0.0244
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0079	0.0079
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.004	0.0079	0.0079
Echinococcus multilocularis	shaker cognate	0.004	0.0079	0.0079
Echinococcus granulosus	hyperpolarization activated cyclic	0.004	0.0079	0.0079
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0847	0.3499	0.3499
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.031	0.031
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.004	0.0079	0.0079
Brugia malayi	Cyclic-nucleotide gated cation channel	0.004	0.0079	0.0079
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0079	0.0079
Schistosoma mansoni	60S ribosomal protein L21	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Toxoplasma gondii	hypothetical protein	0.004	0.0079	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Loa Loa (eye worm)	calcium channel	0.004	0.0079	0.008
Brugia malayi	Pre-SET motif family protein	0.0034	0.0054	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0075	0.0076
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0079	0.0079
Echinococcus granulosus	voltage gated hydrogen channel 1	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0079	0.0079
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0095	0.031	0.031
Toxoplasma gondii	transporter, cation channel family protein	0.004	0.0079	1
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.004	0.0079	0.0244
Loa Loa (eye worm)	voltage-gated calcium channel	0.004	0.0079	0.008
Echinococcus multilocularis	voltage dependent calcium channel	0.004	0.0079	0.0079
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0079	0.0079
Toxoplasma gondii	transporter, cation channel family protein	0.004	0.0079	1
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.004	0.0079	0.0079
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.002	0.368
Echinococcus granulosus	sodium leak channel non selective protein	0.004	0.0079	0.0079
Brugia malayi	cation channel family protein	0.004	0.0079	0.0079
Schistosoma mansoni	hypothetical protein	0.0039	0.0075	0.0075
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.002	1
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.004	0.0079	0.0079
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.004	0.0079	0.008
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0079	0.0079
Echinococcus multilocularis	short transient receptor potential channel 6	0.004	0.0079	0.0079
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0034	0.0054	0.0054
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0079	0.0079
Echinococcus multilocularis	two pore calcium channel protein 2	0.004	0.0079	0.0079
Echinococcus multilocularis	sodium leak channel non selective protein	0.004	0.0079	0.0079
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.004	0.0079	0.0079
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.004	0.0079	0.0079
Echinococcus multilocularis	transient receptor potential gamma protein	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus multilocularis	hyperpolarization activated cyclic	0.004	0.0079	0.0079
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.004	0.0079	0.0079
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Echinococcus multilocularis	short transient receptor potential channel 6	0.004	0.0079	0.0079
Echinococcus granulosus	shaker cognate	0.004	0.0079	0.0079
Echinococcus multilocularis	transfer RNA-Gly	0.004	0.0079	0.0079
Echinococcus granulosus	two pore calcium channel protein 2	0.004	0.0079	0.0079
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0095	0.031	0.031
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0079	0.0079
Loa Loa (eye worm)	ryanodine receptor	0.004	0.0079	0.008
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.024	0.0924	0.094
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.004	0.0079	0.0079
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.031	0.031
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.004	0.0079	0.0079
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.0079	0.0079
Echinococcus granulosus	voltage dependent calcium channel	0.004	0.0079	0.0079
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.004	0.0079	0.0079
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.004	0.0079	0.0079
Echinococcus multilocularis	ryanodine receptor 44f	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0079	0.0079
Brugia malayi	Transient-receptor-potential like protein	0.004	0.0079	0.0079
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.004	0.0079	1
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0079	0.0079
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.004	0.0079	0.0079
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.004	0.0079	0.0079
Echinococcus multilocularis	hyperpolarization activated cyclic	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus multilocularis	two pore calcium channel protein 1	0.004	0.0079	0.0079
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0079	0.0738
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.004	0.0079	1
Leishmania major	hypothetical protein, conserved	0.004	0.0079	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.004	0.0079	0.0079
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0079	0.0079
Leishmania major	hypothetical protein, conserved	0.0026	0.002	0.2526
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.004	0.0079	0.0079
Schistosoma mansoni	transient receptor potential channel 4	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.004	0.0079	0.0244
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.004	0.0079	0.0079
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.004	0.0079	0.0079
Echinococcus granulosus	hypothetical protein	0.004	0.0079	0.0079
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.004	0.0079	0.0079
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0079	0.0079
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0075	0.0075
Schistosoma mansoni	transient receptor potential channel	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus multilocularis	voltage gated potassium channel	0.004	0.0079	0.0079
Echinococcus multilocularis	potassium large conductance calcium activated	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0079	0.0079
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.004	0.0079	0.0079
Schistosoma mansoni	calcium-activated potassium channel	0.004	0.0079	0.0079
Echinococcus granulosus	voltage gated potassium channel	0.004	0.0079	0.0079
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.004	0.0079	0.0079
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0079	0.0079
Echinococcus granulosus	TRP transient receptor potential channel	0.004	0.0079	0.0079
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.0079	0.0079
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.0152	0.0152
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.004	0.0079	0.0079
Loa Loa (eye worm)	voltage-gated potassium channel	0.2341	0.983	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.002	0.2526
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.0152	0.0154
Schistosoma mansoni	ryanodine receptor related	0.004	0.0079	0.0079
Echinococcus granulosus	transient receptor potential cation channel	0.004	0.0079	0.0079
Echinococcus granulosus	short transient receptor potential channel 6	0.004	0.0079	0.0079
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.004	0.0079	1
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.004	0.0079	0.0079
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0079	0.0079
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus multilocularis	transient receptor potential cation channel	0.004	0.0079	0.0079
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0079	0.0079
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0079	0.0079
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.004	0.0079	0.0079
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0079	0.0079
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.004	0.0079	0.0079
Echinococcus granulosus	potassium voltage gated channel protein	0.004	0.0079	0.0079
Echinococcus granulosus	voltage gated potassium channel	0.004	0.0079	0.0079
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0049	0.0049
Brugia malayi	voltage-dependent calcium channel	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.004	0.0079	0.0079
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.004	0.0079	0.0079
Echinococcus granulosus	ryanodine receptor 44f	0.004	0.0079	0.0079
Leishmania major	hypothetical protein, unknown function	0.004	0.0079	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.004	0.0079	0.008
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.004	0.0079	0.0079
Brugia malayi	olfactory channel protein osm-9	0.004	0.0079	0.0079
Toxoplasma gondii	hypothetical protein	0.004	0.0079	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0054	0.0055
Loa Loa (eye worm)	ion channel NompC	0.004	0.0079	0.008
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.004	0.0079	0.0079
Echinococcus granulosus	hyperpolarization activated cyclic	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.0054	0.0054
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.004	0.0079	0.0079
Echinococcus granulosus	calcium activated potassium channel	0.004	0.0079	0.0079
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.004	0.0079	0.0079
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.004	0.0079	0.0079
Loa Loa (eye worm)	voltage-gated potassium channel	0.004	0.0079	0.008
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Echinococcus multilocularis	conserved hypothetical protein	0.004	0.0079	0.0079
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.031	0.031
Echinococcus multilocularis	voltage dependent calcium channel	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0095	0.031	0.031
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.004	0.0079	0.0079
Schistosoma mansoni	transient receptor potential channel	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0026	0.002	0.002
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.004	0.0079	0.0079
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.004	0.0079	0.0079
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.004	0.0079	0.0079
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0095	0.031	0.031
Schistosoma mansoni	transient receptor potential channel	0.004	0.0079	0.0079
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.004	0.0079	1
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.0054	0.0054
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.004	0.0079	0.0079
Echinococcus multilocularis	sodium channel protein	0.004	0.0079	0.0079
Brugia malayi	Pre-SET motif family protein	0.024	0.0924	0.0924
Echinococcus multilocularis	voltage gated potassium channel	0.004	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.004	0.0079	0.008
Loa Loa (eye worm)	voltage-dependent calcium channel	0.004	0.0079	0.008
Schistosoma mansoni	hypothetical protein	0.004	0.0079	0.0079
Brugia malayi	cation channel family protein	0.004	0.0079	0.0079

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709]	ChEMBL.	No reference
Potency (functional)	= 100 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1516809

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1399503