Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | divalent metal transporter DMT1B | 0.0117 | 0.3987 | 1 |
Brugia malayi | NRAMP-like transporter K11G12.4 | 0.0117 | 0.3987 | 1 |
Plasmodium vivax | metal transporter, putative | 0.0117 | 0.3987 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.3987 | 1 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.0117 | 0.3987 | 1 |
Mycobacterium ulcerans | divalent cation-transport integral membrane protein | 0.0045 | 0.1282 | 0.0164 |
Mycobacterium leprae | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) | 0.0072 | 0.2316 | 1 |
Mycobacterium ulcerans | divalent cation-transport integral membrane protein | 0.0045 | 0.1282 | 0.0164 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1237 | 0.3104 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.1237 | 0.5 |
Toxoplasma gondii | divalent metal transporter, putative | 0.0117 | 0.3987 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1237 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1237 | 0.3104 |
Onchocerca volvulus | Protein Malvolio homolog | 0.0117 | 0.3987 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1237 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1237 | 0.3104 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1237 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.1237 | 0.3104 | |
Plasmodium falciparum | transporter, putative | 0.0117 | 0.3987 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1237 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1237 | 0.3104 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.1237 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.1237 | 0.5 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0117 | 0.3987 | 1 |
Brugia malayi | beta-lactamase | 0.0043 | 0.1237 | 0.3104 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.1237 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.1237 | 0.3104 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1237 | 0.3104 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.1237 | 0.3104 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.1237 | 0.3104 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1237 | 0.3104 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.1237 | 0.5 |
Onchocerca volvulus | 0.0043 | 0.1237 | 0.3104 | |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.1237 | 0.3104 |
Onchocerca volvulus | 0.0043 | 0.1237 | 0.3104 | |
Echinococcus multilocularis | divalent metal transporter DMT1B | 0.0117 | 0.3987 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1237 | 0.3104 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1237 | 0.3104 |
Mycobacterium leprae | possible membrane transport protein | 0.0045 | 0.1282 | 0.0417 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.3987 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.1237 | 0.3104 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.1237 | 0.5 |
Mycobacterium tuberculosis | Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) | 0.0072 | 0.2316 | 0.1231 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.1237 | 0.3104 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0117 | 0.3987 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.1237 | 0.3104 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.