Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0808 | 0.2561 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2284 | 0.724 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0086 | 0.0271 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0086 | 0.0271 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.3096 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0808 | 0.0728 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0808 | 0.2561 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0808 | 0.0728 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3155 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0808 | 0.0728 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3155 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.3096 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3155 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1267 | 0.1191 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2284 | 0.724 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0776 | 0.246 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3155 | 0.3096 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0808 | 0.2561 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0086 | 0.0271 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.3096 |
Onchocerca volvulus | 0.0033 | 0.0808 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0808 | 0.0728 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2284 | 0.724 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0808 | 0.0728 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1267 | 0.4015 |
Schistosoma mansoni | lamin | 0.0033 | 0.0808 | 0.0728 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1267 | 0.4015 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2284 | 0.724 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0086 | 0.0271 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0808 | 0.2561 |
Onchocerca volvulus | 0.0033 | 0.0808 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.3096 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3155 | 0.3096 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0808 | 0.0728 |
Schistosoma mansoni | lamin | 0.0033 | 0.0808 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0808 | 0.2561 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3155 | 0.3096 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3155 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.0808 | 0.0728 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.3548 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.6169 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.1995 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.