Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3691 | 0.3691 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.1023 | 0.1023 |
Onchocerca volvulus | 0.0033 | 0.1023 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3691 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0987 | 0.0987 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1023 | 0.1023 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1023 | 0.0928 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3691 | 0.3624 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.1023 | 0.1023 |
Echinococcus multilocularis | musashi | 0.0033 | 0.1023 | 0.1023 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3691 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1023 | 0.1023 |
Onchocerca volvulus | 0.0033 | 0.1023 | 0.5 | |
Echinococcus multilocularis | lamin | 0.0033 | 0.1023 | 0.1023 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1023 | 0.0928 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3691 | 0.3691 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3691 | 0.3691 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3691 | 0.3624 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3691 | 0.3691 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3691 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1023 | 0.1023 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0105 | 0.0105 |
Echinococcus granulosus | lamin | 0.0033 | 0.1023 | 0.1023 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3691 | 0.3624 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.1023 | 0.1023 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3691 | 0.3691 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.5119 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.285 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 12.5893 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.