Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | glutaminase | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Hypothetical protein | 0.0218 | 0.5905 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0218 | 0.5905 | 0.5616 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.3235 | 0.3235 |
Onchocerca volvulus | 0.0218 | 0.5905 | 0.5 | |
Mycobacterium ulcerans | hypothetical protein | 0.0218 | 0.5905 | 0.5616 |
Brugia malayi | Thioredoxin family protein | 0.0218 | 0.5905 | 0.5905 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0218 | 0.5905 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0218 | 0.5905 | 1 |
Echinococcus multilocularis | Transglutaminase | 0.0218 | 0.5905 | 1 |
Mycobacterium tuberculosis | Long conserved protein | 0.0218 | 0.5905 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0218 | 0.5905 | 0.5905 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.3235 | 0.3235 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0658 | 0.0658 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0218 | 0.5905 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0218 | 0.5905 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0658 | 0.5 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0218 | 0.5905 | 0.5616 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0658 | 0.0658 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0218 | 0.5905 | 0.5616 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0218 | 0.5905 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0658 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0658 | 0.1114 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.3235 | 0.3235 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0658 | 0.1114 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0218 | 0.5905 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0218 | 0.5905 | 1 |
Echinococcus granulosus | Transglutaminase | 0.0218 | 0.5905 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.