TDR Targets

Basic information

Technical information

TDR Targets ID: 1407307
Name: SMP2_000193
MW: 354.31 | Formula: C19H14O7
H donors: 1 H acceptors: 2 LogP: 3.34 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(c2c1oc1c3c(OC4C3C=CO4)cc(c1c2=O)OC)O
InChi: 1S/C19H14O7/c1-22-10-4-3-9(20)14-16(21)15-11(23-2)7-12-13(18(15)26-17(10)14)8-5-6-24-19(8)25-12/h3-8,19-20H,1-2H3
InChiKey: VVRUNWFPOWIBDY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS000766244
SMR000528853

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	RAB9A, member RAS oncogene family	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Plasmodium falciparum	ras-related protein Rab-5B	RAB9A, member RAS oncogene family	201 aa	165 aa	30.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0053	0.0128
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0053	0.0053
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0015	0.0125	0.0305
Echinococcus multilocularis	prolyl endopeptidase	0.0015	0.0125	0.0125
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0909	0.7083
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0125	0.0305
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0053	0.0128
Brugia malayi	ecdysteroid receptor	0.0012	0.0053	0.0128
Schistosoma mansoni	hypothetical protein	0.0043	0.0741	0.1811
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0909	0.7083
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0909	0.7083
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0053	0.0128
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0909	0.0909
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0015	0.0125	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0053	0.0128
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1001	0.2447
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0015	0.0125	0.0305
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0909	0.0909
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0053	0.0053
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0053	0.0128
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0053	0.0128
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0909	0.175
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0066	0.1232	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0053	0.0128
Entamoeba histolytica	hypothetical protein	0.0043	0.0741	1
Brugia malayi	prolyl oligopeptidase family protein	0.0015	0.0125	0.0305
Echinococcus granulosus	acylamino acid releasing enzyme	0.0015	0.0125	0.0125
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0909	0.2222
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0053	0.0053
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0741	0.0741
Trypanosoma brucei	protein kinase, putative	0.0051	0.0909	0.7083
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0053	0.0053
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0053	0.0128
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.005	0.0891	0.2176
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0066	0.1232	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0053	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0128
Brugia malayi	prolyl oligopeptidase family protein	0.0195	0.4093	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0128
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0195	0.4093	0.4093
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0053	0.0128
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0053	0.0053
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0909	0.0909
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0053	0.0128
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1001	0.1001
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0053	0.0128
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0909	0.7083
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0053	0.0053
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0053	0.0128
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0066	0.1232	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0053	0.0053
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0066	0.1232	1
Schistosoma mansoni	coup transcription factor	0.0012	0.0053	0.0128
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0015	0.0125	0.5
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.0219	0.4607	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0053	0.0128
Brugia malayi	steroid hormone receptor	0.0012	0.0053	0.0128
Loa Loa (eye worm)	prolyl oligopeptidase	0.0195	0.4093	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1001	0.2447
Entamoeba histolytica	hypothetical protein	0.0043	0.0741	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0053	0.0128
Mycobacterium tuberculosis	Probable peptidase	0.0015	0.0125	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0053	0.0128
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1001	0.2447
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0909	0.7083
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0909	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0053	0.0128
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0053	0.0128
Brugia malayi	hypothetical protein	0.0043	0.0741	0.1811
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0128
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0053	0.0128
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0053	0.0053
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0066	0.1232	0.1232
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0053	0.0128
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0053	0.0053
Echinococcus granulosus	prolyl endopeptidase	0.0015	0.0125	0.0125
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0066	0.1232	0.247
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0128
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0053	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0128
Plasmodium vivax	hypothetical protein, conserved	0.0015	0.0125	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0053	0.0128
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0015	0.0125	0.0305
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0053	0.0128
Brugia malayi	MAP kinase sur-1	0.0051	0.0909	0.2222
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0053	0.0053
Brugia malayi	prolyl oligopeptidase family protein	0.0066	0.1232	0.3011
Brugia malayi	nuclear hormone receptor	0.0012	0.0053	0.0128
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0015	0.0125	0.5
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1001	0.2447
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0909	0.7083
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0909	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0053	0.0128
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.2962	0.7238
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0053	0.0128
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0909	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0053	0.0128
Entamoeba histolytica	hypothetical protein	0.0043	0.0741	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0053	0.0128
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0015	0.0125	0.0305
Brugia malayi	prolyl oligopeptidase family protein	0.0015	0.0125	0.0305
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0053	0.0053
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0053	0.0128
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1001	0.1001
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0053	0.0128
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0066	0.1232	0.1232
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0053	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0128
Brugia malayi	hypothetical protein	0.005	0.0891	0.2176
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0909	0.7083
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0053	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0125	0.0305
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1001	0.1001
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0066	0.1232	0.3011
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0053	0.0053
Brugia malayi	MH2 domain containing protein	0.0144	0.2962	0.7238
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0053	0.0128
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0195	0.4093	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0741	0.0741
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0053	0.0053
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.2962	0.7238
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0053	0.0053
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1001	0.1001
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0909	1
Brugia malayi	prolyl oligopeptidase family protein	0.0015	0.0125	0.0305
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0053	0.0128
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0053	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0128
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0741	0.1811
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0195	0.4093	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1001	0.2447
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0053	0.0053
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0053	0.0053
Entamoeba histolytica	hypothetical protein	0.0043	0.0741	1
Plasmodium falciparum	peptidase, putative	0.0015	0.0125	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0053	0.0128
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0195	0.4093	0.4093
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0053	0.0128
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0015	0.0125	0.0125
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0053	0.0128
Loa Loa (eye worm)	prolyl oligopeptidase	0.0015	0.0125	0.0305
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0053	0.0128
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0909	0.0909
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0053	0.0128
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0066	0.1232	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0125	0.0305
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0909	1
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0015	0.0125	0.0179
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0909	0.2222

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	= 0.698 uM	PUBCHEM_BIOASSAY: Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586]	ChEMBL.	No reference
IC50 (functional)	> 20 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of UBC13 Polyubiquitin Inhibitors via a TR-FRET Assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485273, AID485343, AID493182]	ChEMBL.	No reference
Potency (functional)	0.1 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	= 0.7079 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 2.5119 um	PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.5119 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 2.8184 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.2944 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.5821 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	16.5113 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1541017

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1407307