TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 232.278 | Formula: C13H16N2O2
H donors: 0 H acceptors: 3 LogP: 1.49 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COc1ncc(cn1)C1=CC(=O)CC(C1)(C)C
InChi: 1S/C13H16N2O2/c1-13(2)5-9(4-11(16)6-13)10-7-14-12(17-3)15-8-10/h4,7-8H,5-6H2,1-3H3
InChiKey: DGANCZFJDDYIHZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.001	0.0045	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Schistosoma mansoni	opsin-like receptor	0.0013	0.0121	0.0121
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.002	0.03	0.0339
Brugia malayi	GnHR receptor homolog	0.0013	0.0121	0.0102
Loa Loa (eye worm)	thymidylate synthase	0.006	0.1396	0.1753
Echinococcus granulosus	nmda type glutamate receptor	0.001	0.0045	0.0004
Loa Loa (eye worm)	RGC/RGC protein kinase	0.001	0.0045	0.0009
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.012	0.2996	1
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.001	0.0045	0.0004
Echinococcus multilocularis	glutamate receptor 2	0.001	0.0045	0.0004
Schistosoma mansoni	tyrosine kinase	0.001	0.0045	0.0045
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0297	0.7783	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.0121	0.0107
Brugia malayi	Angiotensin-converting enzyme family protein	0.0296	0.7745	0.9951
Echinococcus granulosus	neuropeptides capa receptor	0.0013	0.0121	0.0102
Brugia malayi	hypothetical protein	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus granulosus	g protein coupled receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus granulosus	biogenic amine 5HT receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0134	0.3389	0.4323
Echinococcus granulosus	integrin alpha ps	0.0014	0.0144	0.0132
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.001	0.0045	0.0004
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0011	0.0065	0.0065
Brugia malayi	hypothetical protein	0.0013	0.0121	0.0102
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0013	0.0121	0.0102
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.001	0.0045	0.0004
Echinococcus granulosus	serotonin receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	glutamate receptor	0.0109	0.2709	0.3449
Schistosoma mansoni	histamine h1 receptor	0.0013	0.0121	0.0121
Brugia malayi	ORL1-like opioid receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0013	0.0121	0.0102
Schistosoma mansoni	biogenic amine receptor	0.0013	0.0121	0.0121
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.012	0.2996	1
Echinococcus multilocularis	sex peptide receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Onchocerca volvulus		0.0013	0.0121	0.0256
Onchocerca volvulus		0.0013	0.0121	0.0256
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0023	0.0382	0.0382
Schistosoma mansoni	amine GPCR	0.0013	0.0121	0.0121
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0023	0.0382	0.0382
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.012	0.2996	1
Echinococcus multilocularis	integrin alpha 3	0.005	0.1107	0.1376
Echinococcus multilocularis	glutamate receptor 2	0.001	0.0045	0.0004
Echinococcus multilocularis	integrin alpha ps	0.0029	0.0551	0.0658
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.012	0.2996	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0121	0.0121
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.006	0.1396	0.4583
Echinococcus granulosus	G protein coupled receptor 139	0.0013	0.0121	0.0102
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0013	0.0121	0.0102
Echinococcus granulosus	7TM GPCR rhodopsin	0.0013	0.0121	0.0102
Schistosoma mansoni	hypothetical protein	0.0012	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.001	0.0045	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0051	0.1139	0.1422
Echinococcus granulosus	receptor type guanylyl cyclase	0.001	0.0045	0.0004
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0121	0.0121
Plasmodium vivax	RNA helicase-1, putative	0.012	0.2996	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0013	0.0121	0.0121
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.012	0.2996	0.5
Schistosoma mansoni	growth hormone secretagogue receptor	0.0013	0.0121	0.0121
Echinococcus multilocularis	neuropeptide Y receptor	0.0013	0.0121	0.0102
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0045	0.0984	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.012	0.2996	0.3816
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.0121	0.0102
Onchocerca volvulus		0.0013	0.0121	0.0256
Brugia malayi	Peptidase family M13 containing protein	0.0045	0.0984	0.1217
Loa Loa (eye worm)	hypothetical protein	0.001	0.0045	0.0009
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.0121	0.0107
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Onchocerca volvulus		0.0013	0.0121	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0688	0.0839
Loa Loa (eye worm)	hypothetical protein	0.001	0.0045	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0013	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0121	0.0121
Echinococcus granulosus	neuropeptide receptor A26	0.0013	0.0121	0.0102
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0013	0.0121	0.0102
Echinococcus granulosus	integrin alpha 3	0.005	0.1107	0.1376
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Onchocerca volvulus		0.0013	0.0121	0.0256
Schistosoma mansoni	protein phosphatase-2b	0.001	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.0012	0.0086	0.0086
Echinococcus multilocularis	tyrosine kinase	0.001	0.0045	0.0004
Onchocerca volvulus		0.006	0.1396	0.4576
Echinococcus granulosus	neuropeptide FF receptor 2	0.0013	0.0121	0.0102
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.006	0.1396	0.4583
Loa Loa (eye worm)	G-protein coupled receptor	0.0013	0.0121	0.0107
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0013	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.012	0.2996	1
Schistosoma mansoni	myosin xvIII	0.0013	0.0121	0.0121
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0013	0.0121	0.0102
Echinococcus multilocularis	nmda type glutamate receptor	0.001	0.0045	0.0004
Schistosoma mansoni	metabotropic glutamate receptor	0.0091	0.2232	0.2232
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.006	0.1396	0.4583
Brugia malayi	putative neuropeptide receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	somatostatin receptor	0.0013	0.0121	0.0102
Brugia malayi	putative neuropeptide receptor NPR1	0.0013	0.0121	0.0102
Echinococcus granulosus	GPCR family 3 C terminal	0.0018	0.0246	0.0264
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0013	0.0121	0.0102
Brugia malayi	Guanylyl cyclase protein 23	0.001	0.0045	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0688	0.0839
Echinococcus multilocularis	serotonin receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	neuropeptide receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	opsin-like receptor	0.0013	0.0121	0.0121
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0013	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0688	0.0839
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0091	0.2232	0.2829
Brugia malayi	RE15519p	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0688	0.0839
Schistosoma mansoni	opsin-like receptor	0.0013	0.0121	0.0121
Brugia malayi	Serotonin receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0012	0.0086	0.0086
Onchocerca volvulus		0.0013	0.0121	0.0256
Echinococcus granulosus	g protein coupled receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	hypothetical protein	0.0018	0.0246	0.0246
Loa Loa (eye worm)	TYRA-2 protein	0.0013	0.0121	0.0107
Brugia malayi	endoprotease bli-4 precursor	0.002	0.03	0.0334
Brugia malayi	neuropeptide F receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0984	0.1221
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0543	0.1553
Trypanosoma cruzi	Aph-1 protein, putative	0.0116	0.2892	0.9647
Schistosoma mansoni	integrin alpha-ps	0.0015	0.0176	0.0176
Loa Loa (eye worm)	hypothetical protein	0.012	0.2996	0.3819
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0732	0.0896
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0246	0.0269
Echinococcus granulosus	neuroendocrine convertase 2	0.0012	0.0103	0.0079
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0121	0.0121
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.012	0.2996	0.3816
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.006	0.1396	1
Leishmania major	eukaryotic initiation factor 4a, putative	0.012	0.2996	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.0121	0.0102
Schistosoma mansoni	neuropeptide F-like receptor	0.0013	0.0121	0.0121
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0045	0.0984	0.1798
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0045	0.0984	0.0984
Echinococcus granulosus	fmrfamide receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	hypothetical protein	0.0012	0.0086	0.0086
Loa Loa (eye worm)	glutamate receptor	0.0043	0.0926	0.1146
Echinococcus granulosus	tyrosine kinase	0.001	0.0045	0.0004
Echinococcus multilocularis	neuropeptide s receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Echinococcus granulosus	atrial natriuretic peptide receptor	0.001	0.0045	0.0004
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0013	0.0121	0.0102
Echinococcus multilocularis	neuropeptides capa receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.001	0.0045	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Onchocerca volvulus		0.0013	0.0121	0.0256
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Brugia malayi	hypothetical protein	0.0013	0.0121	0.0102
Schistosoma mansoni	hypothetical protein	0.0013	0.0121	0.0121
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0028	0.0523	0.0626
Schistosoma mansoni	protein kinase	0.001	0.0045	0.0045
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0176	0.0179
Brugia malayi	Serotonin receptor	0.0013	0.0121	0.0102
Brugia malayi	hypothetical protein	0.0013	0.0121	0.0102
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.002	0.03	0.03
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0013	0.0121	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Echinococcus granulosus	neuropeptides capa receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.0121	0.0102
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0013	0.0121	0.0102
Brugia malayi	follicle stimulating hormone receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.0121	0.0102
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.012	0.2996	1
Brugia malayi	hypothetical protein	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.001	0.0045	0.0009
Onchocerca volvulus		0.0013	0.0121	0.0256
Brugia malayi	Dopamine receptor protein 1	0.0013	0.0121	0.0102
Echinococcus multilocularis	neuropeptide Y receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	dro:myosuppressin receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0013	0.0121	0.0121
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0018	0.0246	0.0264
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0121	0.0121
Schistosoma mansoni	neprilysin	0.0012	0.0086	0.0086
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0297	0.7783	1
Toxoplasma gondii	peptidase family M13 protein	0.0045	0.0984	0.3189
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.001	0.0045	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Onchocerca volvulus		0.0013	0.0121	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Schistosoma mansoni	hypothetical protein	0.0012	0.0086	0.0086
Echinococcus granulosus	glutamate receptor 2	0.001	0.0045	0.0004
Leishmania major	extracellular receptor, putative	0.001	0.0045	0.0012
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.012	0.2996	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0013	0.0121	0.0102
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.012	0.2996	1
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0011	0.0065	0.0065
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0013	0.0121	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0121	0.0121
Loa Loa (eye worm)	melatonin receptor type 1A	0.0013	0.0121	0.0107
Schistosoma mansoni	tyrosine kinase	0.001	0.0045	0.0045
Schistosoma mansoni	amine GPCR	0.0013	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.001	0.0045	0.0004
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0013	0.0121	0.0121
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0011	0.0065	0.0065
Brugia malayi	celfurPC protein	0.0016	0.0197	0.0201
Brugia malayi	hypothetical protein	0.0029	0.0543	0.0647
Onchocerca volvulus		0.0013	0.0121	0.0256
Brugia malayi	larval opioid receptor	0.0013	0.0121	0.0102
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0029	0.0543	0.1696
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.006	0.1396	0.4583
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	RGC/RGC protein kinase	0.001	0.0045	0.0009
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.006	0.1396	0.4583
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	hypothetical protein	0.0012	0.0086	0.0086
Echinococcus granulosus	sex peptide receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0121	0.0121
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0013	0.0121	0.0107
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0012	0.0092	0.0065
Loa Loa (eye worm)	RGC/RGC protein kinase	0.001	0.0045	0.0009
Brugia malayi	G-protein coupled receptor	0.0013	0.0121	0.0102
Onchocerca volvulus		0.0013	0.0121	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus multilocularis	G protein coupled receptor 139	0.0013	0.0121	0.0102
Echinococcus granulosus	g-protein coupled receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0013	0.0121	0.0102
Schistosoma mansoni	neuropeptide f receptor 76f	0.0013	0.0121	0.0121
Plasmodium falciparum	eukaryotic initiation factor 4A	0.012	0.2996	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0144	0.0137
Brugia malayi	Receptor family ligand binding region containing protein	0.0028	0.0523	0.0621
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0371	0.043
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0121	0.0121
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0013	0.0121	0.0107
Schistosoma mansoni	hypothetical protein	0.0012	0.0086	0.0086
Brugia malayi	Integrin alpha pat-2 precursor	0.0065	0.1514	0.1902
Echinococcus granulosus	hypothetical protein	0.0013	0.0121	0.0102
Schistosoma mansoni	hypothetical protein	0.0014	0.0144	0.0144
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0011	0.0065	0.0065
Echinococcus multilocularis	neuropeptide receptor A26	0.0013	0.0121	0.0102
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0018	0.0246	0.068
Echinococcus multilocularis	neuroendocrine convertase 2	0.0012	0.0103	0.0079
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0013	0.0121	0.0102
Echinococcus granulosus	endothelin converting enzyme 1	0.0045	0.0984	0.1217
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0297	0.7783	0.7783
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0013	0.0121	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Schistosoma mansoni	integrin alpha	0.0065	0.1514	0.1514
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0012	0.0092	0.0065
Brugia malayi	hypothetical protein	0.0013	0.0121	0.0102
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.012	0.2996	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Brugia malayi	G protein-coupled receptor F59B2.13	0.0013	0.0121	0.0102
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0121	0.0121
Echinococcus granulosus	glutamate receptor 2	0.001	0.0045	0.0004
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0013	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0688	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus granulosus	neuropeptide Y receptor	0.0013	0.0121	0.0102
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0099	0.2433	0.3088
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0134	0.3389	0.4323
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0023	0.0382	0.0382
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0121	0.0121
Onchocerca volvulus		0.0013	0.0121	0.0256
Brugia malayi	hypothetical protein	0.0013	0.0121	0.0102
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0013	0.0121	0.0102
Onchocerca volvulus		0.0013	0.0121	0.0256
Schistosoma mansoni	biogenic amine receptor	0.0013	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	integrin alpha ps	0.0014	0.0144	0.0132
Echinococcus multilocularis	receptor type guanylyl cyclase	0.001	0.0045	0.0004
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0013	0.0121	0.0256
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.001	0.0045	0.0004
Echinococcus multilocularis	fmrfamide receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Echinococcus granulosus	eukaryotic initiation factor 4A	0.012	0.2996	0.3816
Schistosoma mansoni	hypothetical protein	0.0013	0.0121	0.0121
Mycobacterium ulcerans	thymidylate synthase	0.006	0.1396	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0667	0.0812
Brugia malayi	hypothetical protein	0.0013	0.0121	0.0102
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Echinococcus multilocularis	g protein coupled receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	endothelin converting enzyme 1	0.0045	0.0984	0.1217
Echinococcus multilocularis	dro:myosuppressin receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	integrin alpha pat-2	0.01	0.2459	0.3126
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1089	0.1357
Echinococcus multilocularis	allatostatin A receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	endothelin-converting enzyme-related	0.0011	0.0065	0.0065
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0013	0.0121	0.0256
Loa Loa (eye worm)	endoprotease bli-4	0.002	0.03	0.0339
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	neuropeptide Y receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Brugia malayi	neuropeptide F receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0011	0.0065	0.0065
Echinococcus granulosus	7tm_1 domain containing protein	0.0013	0.0121	0.0102
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.0121	0.0121
Echinococcus granulosus	somatostatin receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Brugia malayi	hypothetical protein	0.001	0.0045	0.0004
Trypanosoma brucei	Aph-1 protein, putative	0.0116	0.2892	0.9647
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0023	0.0382	0.0382
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.012	0.2996	0.2996
Brugia malayi	AKH receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	biogenic amine receptor	0.0013	0.0121	0.0121
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Schistosoma mansoni	neuropeptide F-like receptor	0.0013	0.0121	0.0121
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0109	0.2709	0.3446
Echinococcus multilocularis	neuropeptides capa receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	serotonin receptor	0.0013	0.0121	0.0102
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0018	0.0246	0.0264
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Brugia malayi	neuroendocrine convertase 1 precursor	0.0012	0.0103	0.0079
Echinococcus granulosus	neuropeptide s receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0984	0.1221
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0688	0.0839
Loa Loa (eye worm)	hypothetical protein	0.0134	0.3389	0.4326
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.012	0.2996	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0667	0.0812
Echinococcus multilocularis	integrin alpha ps	0.0029	0.0551	0.0658
Echinococcus multilocularis	orexin receptor type 2	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.001	0.0045	0.0009
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.001	0.0045	0.0004
Onchocerca volvulus		0.0013	0.0121	0.0256
Brugia malayi	sulfakinin receptor protein	0.0013	0.0121	0.0102
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.001	0.0045	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.012	0.2996	0.3816
Echinococcus multilocularis	fmrfamide receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	allatostatin A receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	g-protein coupled receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0013	0.0121	0.0121
Brugia malayi	Melatonin receptor type 1A	0.0013	0.0121	0.0102
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0296	0.7745	0.9951
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0013	0.0121	0.0102
Loa Loa (eye worm)	hypothetical protein	0.001	0.0045	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0667	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Brugia malayi	Receptor family ligand binding region containing protein	0.001	0.0045	0.0004
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Onchocerca volvulus		0.0013	0.0121	0.0256
Loa Loa (eye worm)	hypothetical protein	0.001	0.0045	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0984	0.1221
Echinococcus granulosus	gamma secretase subunit aph 1	0.0297	0.7783	1
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.006	0.1396	0.1396
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.0121	0.0102
Schistosoma mansoni	neuropeptide receptor	0.0013	0.0121	0.0121
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.0121	0.0121
Schistosoma mansoni	amine GPCR	0.0013	0.0121	0.0121
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0049	0.1089	0.1353
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.006	0.1396	0.4583
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0013	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Brugia malayi	hypothetical protein	0.0013	0.0121	0.0102
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0013	0.0121	0.0102
Echinococcus granulosus	orexin receptor type 2	0.0013	0.0121	0.0102
Onchocerca volvulus	Poor gastrulation protein homolog	0.0018	0.0246	0.068
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0013	0.0121	0.0107
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0028	0.0523	0.0626
Schistosoma mansoni	glutamate receptor NMDA	0.001	0.0045	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Brugia malayi	G-protein coupled receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.001	0.0045	0.0004
Treponema pallidum	ATP-dependent RNA helicase	0.012	0.2996	0.5
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0069	0.1629	0.1629
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0013	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0523	0.0626
Brugia malayi	eukaryotic initiation factor 4A	0.012	0.2996	0.3816
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0023	0.0382	0.0382
Echinococcus granulosus	furin	0.002	0.03	0.0334
Brugia malayi	thymidylate synthase	0.006	0.1396	0.1749
Echinococcus granulosus	thymidylate synthase	0.006	0.1396	0.1749
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0013	0.0121	0.0102
Echinococcus granulosus	neuropeptide receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	amine GPCR	0.0013	0.0121	0.0121
Onchocerca volvulus		0.0013	0.0121	0.0256
Brugia malayi	gamma-secretase subunit aph-1	0.0297	0.7783	1
Leishmania major	eukaryotic initiation factor 4a, putative	0.012	0.2996	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0013	0.0121	0.0121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0121	0.0121
Echinococcus multilocularis	thymidylate synthase	0.006	0.1396	0.1749
Schistosoma mansoni	hypothetical protein	0.0013	0.0121	0.0121
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0013	0.0121	0.0121
Trypanosoma cruzi	Aph-1 protein, putative	0.0116	0.2892	0.9647
Echinococcus granulosus	neuropeptide receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	hypothetical protein	0.0013	0.0121	0.0121
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.006	0.1396	0.3477
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0013	0.0121	0.0121
Brugia malayi	hypothetical protein	0.0013	0.0121	0.0102
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0013	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Schistosoma mansoni	amine GPCR	0.0013	0.0121	0.0121
Echinococcus multilocularis	neuropeptide receptor	0.0013	0.0121	0.0102
Loa Loa (eye worm)	neuropeptide F receptor	0.0013	0.0121	0.0107
Echinococcus granulosus	tm gpcr rhodopsin	0.0013	0.0121	0.0102
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0013	0.0121	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0667	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0011	0.0065	0.0035
Schistosoma mansoni	protein phosphatase-2b	0.001	0.0042	0.0042
Echinococcus granulosus	integrin alpha ps	0.0029	0.0551	0.0658
Brugia malayi	peptidase family M13 containing protein	0.0011	0.0065	0.003
Loa Loa (eye worm)	hypothetical protein	0.001	0.0042	0.0005
Brugia malayi	Dopamine receptor protein 2	0.0013	0.0121	0.0102
Brugia malayi	proprotein convertase 2	0.0012	0.0103	0.0079
Brugia malayi	metabotropic glutamate receptor type 2	0.0053	0.1202	0.1499
Schistosoma mansoni	adenoreceptor	0.0013	0.0121	0.0121
Echinococcus granulosus	g protein coupled receptor	0.0013	0.0121	0.0102
Echinococcus granulosus	rhodopsin orphan GPCR	0.0013	0.0121	0.0102
Schistosoma mansoni	integrin alpha-ps	0.0029	0.0551	0.0551
Onchocerca volvulus		0.0013	0.0121	0.0256
Schistosoma mansoni	metabotropic glutamate receptor	0.0053	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Brugia malayi	Dopamine receptor	0.0013	0.0121	0.0102
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0091	0.2232	0.2829
Trypanosoma cruzi	extracellular receptor, putative	0.001	0.0045	0.0012
Brugia malayi	G protein-coupled receptor	0.0013	0.0121	0.0102
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0124	0.3112	0.3112
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.001	0.0045	0.0004
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.012	0.2996	0.2996
Onchocerca volvulus		0.0022	0.0371	0.1103
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0033	0.0667	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0121	0.0107
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0033	0.0667	0.0812
Echinococcus multilocularis		0.0016	0.0197	0.0201

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1563602

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1408340